Thyroid Autoimmunity Induced by Interferon Therapy
We have previously reported  that patients with carcinoid tumors on long-term therapy with human leukocyte-derived (huLe) interferon (IFN) may develop signs of thyroid autoimmunity: among 49 patients hyperthyroidism occurred in two and hypothyroidism in five. Antibodies against thyroid microsomal antigen and/or thyroglobulin were found in 13 patients, and in 7 of these the antibodies appeared after the start of therapy. In the present report, we have extended these observations in a larger patient series and include data on patients given long-term treatment with recombinant (r) IFNα. Moreover, the occurrence of simple epithelial cell autoantibodies, frequently seen in carcinoid patients receiving huLe-IFNα , and the correlation of these autoantibodies to thyroid dysfunction and/or thyroid-specific antibodies, was examined in sera from patients given huLe-IFNα or r-IFNα.
KeywordsCarcinoid Tumor Thyroid Dysfunction Autoimmune Thyroiditis Thyroid Autoantibody Autoimmune Endocrine
Unable to display preview. Download preview PDF.
- 2.Karlsson-Parra A, Burman P, Öberg K, Hagberg H, Klareskog L, Karlsson FA (1990) Autoantibodies to epithelial cells in patients on long term therapy with leukocyte-derived interferon-alpha (IFNα) Clin Exp Immunol 81:72–75Google Scholar
- 5.Gisslinger H, Gilly B, Weissci M (1989) Occurrence of thyroid autoimmunity in patients on long-term treatment with recombinant interferon alpha. 18th annual meeting of the European Thyroid Association, Copenhagen, Denmark, June 26–30, 1989. Ann Endocrinol 50/2: abstr 152Google Scholar
- 6.Schultz M, Muller R, Von Zur Muhlen A, Brabant G (1989) Induction of hyperthyroidism by interferon-α-2b. Lancet i: 1452Google Scholar
- 7.Golub SH (1984) Immunological and therapeutic effects of interferon treatment of cancer patients. Clin Immunol Allergy 4:377–391Google Scholar
- 10.Amino N, Miyai K (1983) Postpartum autoimmune endocrine syndromes. In: Davis TF (ed) Autoimmune endocrine disease. Wiley, New York, pp 247–272Google Scholar
- 13.Berg K, Osther K, Heron I (1980) Production, purification and properties of human interferons. In: Strengfellow DA (ed) Interferon and interferon inducers. Marcel Dekker, New York, pp 21–55Google Scholar