Thyroid Autoimmunity Induced by Interferon Therapy

  • F. A. Karlsson
  • P. Burman
  • K. Öberg
  • A. Karlsson-Parra
Conference paper

Abstract

We have previously reported [1] that patients with carcinoid tumors on long-term therapy with human leukocyte-derived (huLe) interferon (IFN) may develop signs of thyroid autoimmunity: among 49 patients hyperthyroidism occurred in two and hypothyroidism in five. Antibodies against thyroid microsomal antigen and/or thyroglobulin were found in 13 patients, and in 7 of these the antibodies appeared after the start of therapy. In the present report, we have extended these observations in a larger patient series and include data on patients given long-term treatment with recombinant (r) IFNα. Moreover, the occurrence of simple epithelial cell autoantibodies, frequently seen in carcinoid patients receiving huLe-IFNα [2], and the correlation of these autoantibodies to thyroid dysfunction and/or thyroid-specific antibodies, was examined in sera from patients given huLe-IFNα or r-IFNα.

Keywords

Interferon Hypothyroidism Hyperthyroidism Thyroxine Thyroiditis 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Burman P, Tötterman TH, Öberg K, Karlsson FA (1986) Thyroid autoimmunity in patients on long term therapy with leukocyte-derived interferon. J Clin Endocrinol Metab 63:1086–1090.PubMedCrossRefGoogle Scholar
  2. 2.
    Karlsson-Parra A, Burman P, Öberg K, Hagberg H, Klareskog L, Karlsson FA (1990) Autoantibodies to epithelial cells in patients on long term therapy with leukocyte-derived interferon-alpha (IFNα) Clin Exp Immunol 81:72–75Google Scholar
  3. 3.
    Öberg K, Funa K, Alm G (1983) Effect of leukocyte interferon on clinical symptoms and hormone levels in patients with mid-gut carcinoid tumors and carcinoid syndrome. N Engl J Med 309:129–133PubMedCrossRefGoogle Scholar
  4. 4.
    Fentiman IS, Balkwill FR, Thomas BS, Rusell MJ, Todd I, Bottazzo GF (1988) An autoimmune aetiology for hypothyroidism following interferon therapy for breast cancer. Eur J Cancer Clin Oncol 24:1299–1303PubMedCrossRefGoogle Scholar
  5. 5.
    Gisslinger H, Gilly B, Weissci M (1989) Occurrence of thyroid autoimmunity in patients on long-term treatment with recombinant interferon alpha. 18th annual meeting of the European Thyroid Association, Copenhagen, Denmark, June 26–30, 1989. Ann Endocrinol 50/2: abstr 152Google Scholar
  6. 6.
    Schultz M, Muller R, Von Zur Muhlen A, Brabant G (1989) Induction of hyperthyroidism by interferon-α-2b. Lancet i: 1452Google Scholar
  7. 7.
    Golub SH (1984) Immunological and therapeutic effects of interferon treatment of cancer patients. Clin Immunol Allergy 4:377–391Google Scholar
  8. 8.
    Trinchieri G, Santoli D, Koprowski H (1978) Spontaneous cell-mediated cytotoxicity in humans; role of interferon and immunoglobulins. J Immunol 120:1849–1855PubMedGoogle Scholar
  9. 9.
    Jansson R, Karlsson FA, Dahlberg PA (1984) Thyroxine, thyroiditis, metimazole, and thyroid microsomal autoantibody titers in hypothyroid Hashimoto’s thyroiditis. Br Med J 290:11–12CrossRefGoogle Scholar
  10. 10.
    Amino N, Miyai K (1983) Postpartum autoimmune endocrine syndromes. In: Davis TF (ed) Autoimmune endocrine disease. Wiley, New York, pp 247–272Google Scholar
  11. 11.
    Jansson R, Dahlberg PA, Karlsson FA (1988) Postpartum thyroiditis. Ballière’s Clin Endocrinol Metab 2:619–635CrossRefGoogle Scholar
  12. 12.
    Lindahl P, Leary P, Gresser I (1974) Enhancement of expression of histocompatibility antigens on mouse lymphoid cells by interferon in vitro. Eur J Immunol 4:779–784CrossRefGoogle Scholar
  13. 13.
    Berg K, Osther K, Heron I (1980) Production, purification and properties of human interferons. In: Strengfellow DA (ed) Interferon and interferon inducers. Marcel Dekker, New York, pp 21–55Google Scholar
  14. 14.
    Buller RML, Holmes KL, Hugin A et al. (1987) Induction of cytotoxic T cell responses in vivo in the absence of CD4 helper cells. Nature 328:77–79PubMedCrossRefGoogle Scholar
  15. 15.
    Atkins MB, Mier MW, Parkinson DR, Gould JA, Berkman EM, Kaplan MM (1988) Hypothyroidism after treatment with interleukin-2 and lymphokine-activated killer cells. N Engl J Med 318:1557–1563PubMedCrossRefGoogle Scholar
  16. 16.
    Heremans J, Billiau A, Colombatti A, Hilgers J, De Somer P (1978) Interferon treatment of NZB mice: accelerated progression of autoimmune disease. Infect Immun 21:925–930PubMedGoogle Scholar
  17. 17.
    Gould CL, McMannama KG, Bigley NJ, Giron DJ (1985) Exacerbation of the pathogenesis of the diabetogenic variant of encephalomyocarditis virus in mice by interferon. J Interferon Res 5:33–37PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • F. A. Karlsson
  • P. Burman
  • K. Öberg
  • A. Karlsson-Parra

There are no affiliations available

Personalised recommendations