Goiter and Autoimmune Thyroiditis in Iodine-Sufficient Areas

  • E. Gaitan
  • R. C. Cooksey
  • D. Gaitan
  • J. Legan
  • E. F. Meydrech
  • J. M. Montalvo
  • J. A. Pino
  • G. S. Gaitan
  • J. Astudillo
  • R. Guzman
  • N. Guzman
  • E. Duque
  • H. Gallo


Goiter continues to occur, despite adequate iodine supplementation, in the coal-rich Appalachian area of eastern Kentucky in the United States [1–3] and in many shale- and coal-rich localities of western Colombia [4]. The incidence of lymphocytic autoimmune thyroiditis (AT) has steadily increased in the United States during the past five decades, and this has been attributed to iodine prophylaxis since 1924 and to excessive iodine intake [1,5–7]. In western Colombia, where iodine prophylaxis was instituted in 1955, a similar trend has been documented, both in autopsy (1959–1972) and surgically (1953–1973) removed thyroid glands [8]. However, lymphocytic infiltration was of high degree in all the cases in the United States [7] while it was minimal in 71.4% of the Colombian cases [8]. Urinary iodine excretion values from 1960 to 1974 ranged between 108 and 633 µg/gCr in schoolchildren and between 229 and 758 µ/gCr in adults living in the areas of western Colombia where the autopsy and surgical materials had been obtained [4, 9–12], However, retrospective studies of this kind have differences in methodology and design which limit the ability to make valid comparisons. Thus, cross-sectional and prospective studies designed to reassess the problem of goiter and AT in areas of eastern Kentucky and western Colombia, where goiter persists despite iodine supplementation, have been conducted since 1983. Nearby localities where goiter has not been a problem were similarly investigated.


Iodine Deficiency Iodine Intake Autoimmune Thyroiditis Endemic Goiter Thyroid Autoantibody 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • E. Gaitan
  • R. C. Cooksey
  • D. Gaitan
  • J. Legan
  • E. F. Meydrech
  • J. M. Montalvo
  • J. A. Pino
  • G. S. Gaitan
  • J. Astudillo
  • R. Guzman
  • N. Guzman
  • E. Duque
  • H. Gallo

There are no affiliations available

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