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Mechanisms by Which Iodine Induces Autoimmunity

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Autoimmune Thyroiditis

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Abstract

The evidence that iodine may be a causative agent in autoimmune thyroiditis is substantial. Persuasive data derive from studies of the epidemiology of thyroid autoimmunity in human populations as well as experimental manipulations of animal models. These are summarized in this report. We then discuss several hypothetical mechanisms by which excess iodine may induce thyroid autoimmunity. Finally, we propose a number of experiments using animal models and patients with Hashimoto’s thyroiditis to test our hypotheses.

This work was supported by grants from the National Institutes of Health (DK-20028, DK-35846).

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Authors
  1. R. S. Sundick
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  2. N. Bagchi
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  3. T. R. Brown
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Editor information

Editors and Affiliations

  1. Medizinische Klinik und Poliklinik, Abt. Innere Medizin, Universität Ulm, Robert-Koch-Str. 8, 7900, Ulm, Germany

    W. A. Scherbaum

  2. Abt. für Allgemeine Innere Medizin und Nephrologie, Medizinische Klinik und Poliklinik, Hindenburgdamm 30, 1000, Berlin 45, Germany

    U. Bogner

  3. Karlsbergstr. 20, 6650, Homburg/Saar, Germany

    B. Weinheimer

  4. Department of Immunology, The London Hospital Medical College, Turner Street, London, E1 2AD, UK

    G. F. Bottazzo

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© 1991 Springer-Verlag Berlin Heidelberg

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Sundick, R.S., Bagchi, N., Brown, T.R. (1991). Mechanisms by Which Iodine Induces Autoimmunity. In: Scherbaum, W.A., Bogner, U., Weinheimer, B., Bottazzo, G.F. (eds) Autoimmune Thyroiditis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76301-4_19

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  • DOI: https://doi.org/10.1007/978-3-642-76301-4_19

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-53476-1

  • Online ISBN: 978-3-642-76301-4

  • eBook Packages: Springer Book Archive

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