Thyroid Microsome/Thyroid Peroxidase Autoantigenic Epitopes Recognized by Autoantibodies Map to the Amino Terminal, the Central Core and the Carboxyl Terminal of the Molecule
The occurrence of autoantibodies (aAbs) to thyroid proteins is a feature of autoimmune thyroid disease (AITD) and a common serological marker for disease activity . Although their precise role in the aetiology of AITD remains speculative, considerable evidence has accumulated to the effect that aAbs to the thyroid microsome/thyroid peroxidase antigen (TMA/TPO) may be pathogenetic . TPO is a well-characterized enzyme involved in the generation of thyroid hormones from thyroglobulin and comprises a 105-kDa protein  which has recently been cloned . Two forms of TPO cDNA have been reported, termed TPO-1 and TPO-2, with exon 10 coding for 57 amino acids is spliced from the coding sequence of the shorter TPO-2 cDNA .
KeywordsThyroid Peroxidase Eukaryotic Expression System Recombinant Polypeptide Human Thyroid Cell Allele Specific Oligonucleotide Probe
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