Abstract
Investigations of immune responses to exogenous antigens suggest that antibodies tend to interact with conformational, non-linear regions of polypeptides whereas T cells recognize short, lenear amino acid sequences of denatured antigen in association with MHC molecules. Further, detailed analyses of peptides stimulatory for T cells have indicated that such T cell “epitopes” have characteristic patterns of amino acids which may be predicted according to the algorithms of Rothbard [1] or Berzofsky [2].
This research was supported in part by the Wellcome Trust.
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References
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© 1991 Springer-Verlag Berlin Heidelberg
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Fukuma, N., McLachlan, S., Phillips, D.I.W., Pegg, C.A.S., Rapoport, B., Smith, B.R. (1991). T Cell Epitopes and Thyroid Peroxidase. In: Scherbaum, W.A., Bogner, U., Weinheimer, B., Bottazzo, G.F. (eds) Autoimmune Thyroiditis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76301-4_14
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DOI: https://doi.org/10.1007/978-3-642-76301-4_14
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