Abstract
In patients with autoimmune thyroid disease the presence of autoantibodies against several distinct antigens including the TSH receptor, thyroglobulin, and the microsomal antigens (MAg) is well established. The MAg is a glycoprotein of an apparent molecular weight of about 100kDa [1–3], and its major antigenic component is thyroid peroxidase (TPO) [4–7]. Recently published studies have suggested a heterogeneous nature of autoantibodies directed against TPO (anti-TPO-Abs) [8] and reported that anti-TPO-Abs not only bound to TPO but also inhibited its enzymatic activity [9–12]. However, the important question of whether the antigenic determinants of TPO include its catalytic sites is presently controversial, since another study failed to find any inhibition of TPO activity by anti-TPO-Abs [4].
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© 1991 Springer-Verlag Berlin Heidelberg
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Saller, B., Hörmann, R., Mann, K. (1991). Biochemical Dissection of the Reactivity of TPO Antibodies. In: Scherbaum, W.A., Bogner, U., Weinheimer, B., Bottazzo, G.F. (eds) Autoimmune Thyroiditis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76301-4_13
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DOI: https://doi.org/10.1007/978-3-642-76301-4_13
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