Further Clarification of the Significance of Thyroid Peroxidase Activity-Inhibiting Immunoglobulins in Autoimmune Thyroid Disease
Antibodies against human microsomal antigens are often present in autoimmune thyroid disease and have been found to be antibodies against thyroid peroxidase (TPO) [1–3], which catalyzes the synthesis of thyroid hormone. We have reported  that some anti-TPO antibodies inhibit the activity of TPO in vitro, and that these TPO activity-inhibiting immunoglobulins (TPII) seem to inhibit thyroid function in some patients, but the relationship between TPII index and thyroid function is not simple. In this study, we examined whether TPII can inhibit the activity of TPO present in thyroid tissue.
KeywordsAutoimmune Thyroid Disease Thyroid Peroxidase Thyroid Follicle Organ Culture System Microsomal Antibody
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