Abstract
In previous studies we have reported on the faecal bile acids in patients with chronic ulcerative colitis and in familial adenomatous polyposis (FAP) patients. In the former group of patients there was a relationship between the faecal bile acid concentration and the severity of epithelial dysplasia and the risk of colorectal cancer. The latter group were characterised by a lack of bacterial metabolites despite the bacterial flora having a normal composition and having normal bile acid degradative activity in vitro. These results suggested that in FAP there was an inhibitor of bacterial metabolism present in the colon and secreted either by the colonic mucosa or in some small intestinal secretion (e.g. bile).
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© 1991 Springer-Verlag Berlin Heidelberg
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Hill, M.J., Owen, R.W. (1991). Faecal bile acids in pouch and pouchitis patients. In: Nicholls, R.J., Mortensen, N.J.M., Northover, J.M.A. (eds) Topics in Colorectal Disease. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76281-9_20
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DOI: https://doi.org/10.1007/978-3-642-76281-9_20
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-53447-1
Online ISBN: 978-3-642-76281-9
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