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Advances in Mutagenesis Research pp 28–52Cite as

Cellular and Molecular Effects of Radon and Other Alpha Particle Emitters

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Part of the book series: Advances in Mutagenesis Research ((MUTAGENESIS,volume 3))

Abstract

It has long been known that the inhalation of radon gas induces lung cancer, as indicated by evidence provided by epidemiological studies of uranium (R.D. Evans et al. 1981; Samet 1989; Samet et al. 1989) and tin (Lubin et al. 1990) miners as well as by studies using experimental animals (Cross et al. 1985; Lafuma et al. 1989). The induction of lung cancer increases linearly with dose, and the efficiency of induction increases with a decrease in the exposure rate (Little et al. 1985; BEIR IV Report 1988; Lubin et al. 1990; Moolgavcar et al. 1990). However, the realization that indoor radon can reach levels sufficient to cause a significant increase in the risk of lung cancer for the general population became an issue of concern in 1986, when engineer Stanley Watras set off the radiation monitor at the Limerick nuclear power plant in eastern Pennsylvania. Subsequent measurements showed radon levels in his home amounting to 2700 pCi/l, a level markedly higher than that experienced by the majority of uranium miners (10–20 pCi/l), and decidedly higher than the estimated average US indoor radon level of 1.5 pCi/l (Nero et al. 1986). It has been calculated that as many as 16 000 of the 140 000 cases of lung cancer occurring annually in the United States may result from the inhalation of radon (Brenner 1989).

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  1. Department of Radiology, Case Western Reserve University, 44106, Cleveland, OH, USA

    H. H. Evans

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  1. FB9 der Universität, Gesamthochschule Essen, Universitätsstraße 5, Postfach 103764, 4300, Essen 1, Germany

    Günter Obe

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Evans, H.H. (1991). Cellular and Molecular Effects of Radon and Other Alpha Particle Emitters. In: Obe, G. (eds) Advances in Mutagenesis Research. Advances in Mutagenesis Research, vol 3. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76232-1_2

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  • DOI: https://doi.org/10.1007/978-3-642-76232-1_2

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