Concluding Remarks

  • Erich Gebhart
  • Ruben M. Arutyunyan


Anticlastogenesis is an essential part of antimutagenesis. Basic and applied research on anticlastogens has not only revealed very valuable evidence of the mechanisms active in the induction of chromosomal aberrations by environmental mutagens and the principles of its modification, but it has also contributed effective concepts on the practical employment of this knowledge to the protection of individuals at risk. Particularly the findings on the anticlastogenic potential of “natural” substances (e.g., vitamins, amino acids, fatty acids, various plant anti-mutagens, and others) have essentially expedited these ideas. The problems of dietary inhibition of mutagenesis and carcinogenesis became one of the most important directions of research in the 1980s. The public interest has increasingly focused on these problems, especially since the works of Sugimura (1982), Ames (1983,1984,1986), and Wattenberg (1983). Not only large international conferences on the mechanisms of antimutagenesis and anticarcinogenesis in 1985 and 1988 (and most recently 1991) with the subsequent publication of the proceedings by Shankel et al. (1986) and Kuroda et al. (1990), a special issue of Mutation Research edited by de Flora (1988), but also many recent review publications reflect the intense research and interest in this area. Apparently, some of the dietary anti-mutagens (anticlastogens) show clear associations to epidemiological factors, not only on the basis of their general nature but also due to the very subtle peculiarities of their chemical structure, as pointed out recently by Renner (1990a,b)


Chromosomal Aberration Intense Research Epidemiological Factor Mutation Research Valuable Evidence 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • Erich Gebhart
    • 1
  • Ruben M. Arutyunyan
    • 2
  1. 1.Institut für HumangenetikUniversität Erlangen-NürnbergErlangenGermany
  2. 2.Department of BiologyState University of YerevanYerevanUSSR

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