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Polymerization of Microtubule Proteins from Antarctic Fish

  • Conference paper
Biology of Antarctic Fish

Abstract

Microtubules are a major component of the cytoskeleton of most eukaryotic cells. They participate in many fundamental processes, including mitosis, nerve growth and regeneration, the intracellular transport of organelles, and the determination of cell shape. The formation of microtubules from their subunit proteins, tubulin αβ dimers and microtubule-associated proteins (MAPs), is an entropically driven process that is favored by high temperatures (Correia and Williams 1983). For example, the microtubule proteins of mammals and birds polymerize to yield microtubules at temperatures near 37 °C, but these polymers are “cold-labile”; they disassemble to their subunits at low temperatures (0–4 °C). How, then, do the microtubules of cold-living poikilotherms (e.g., the fish of the antarctic marine ecosystem) assemble and function at body temperatures as low as −1.9 °C?

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Author information

Authors and Affiliations

  1. Department of Biology, Northeastern University, Boston, Massachusetts, 02115, USA

    H. W. Detrich III

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  1. H. W. Detrich III
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Editor information

Editors and Affiliations

  1. Institute of Protein Biochemistry and Enzymology (IBPE), Italian National Research Council, Via Marconi 10, I-80125, Naples, Italy

    Guido di Prisco

  2. International Institute of Genetics and Biophysics, CNR, I-80125, Naples, Italy

    Bruno Maresca

  3. University of Calabria, I-87030, Arcavacata di Rende (CS), Italy

    Bruno Tota

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© 1991 Springer-Verlag Berlin Heidelberg

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Detrich, H.W. (1991). Polymerization of Microtubule Proteins from Antarctic Fish. In: di Prisco, G., Maresca, B., Tota, B. (eds) Biology of Antarctic Fish. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76217-8_17

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  • DOI: https://doi.org/10.1007/978-3-642-76217-8_17

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-76219-2

  • Online ISBN: 978-3-642-76217-8

  • eBook Packages: Springer Book Archive

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