X-Linkage

Abstract

As discussed at the beginning of Sect. 3.2, X-linked loci are of particular interest and usefulness in human, mouse, and Drosophila genetics. In species with arrhenotokous parthenogenesis, all loci are effectively X-linked. We shall confine ourselves to discrete, nonoverlapping generations; for the continuous-time theory, the reader may refer to Nagylaki (1975c). In Sect. 7.1 we present the general formulation for selection and mutation with multiple alleles. We discuss the dynamics of selection with two alleles in Sect. 7.2 and treat multiallelic mutation-selection balance in Sect. 7.3. A weak-selection analysis of multiallelic selection is carried out in Sect. 7.4. The formulation and analysis of selection at an autosomal locus in a dioecious population resembles the theory for X-linkage; see Problem 7.4 and Nagylaki (1979b).