Functional Recovery After Cerebral Ischemia: Studies in the Motor System

  • F. Chollet
  • V. Di Piero
  • R. J. S. Wise
  • A. Rascol
  • R. S. J. Frackowiak
Conference paper


Positron emission tomography (PET) allows us to measure activity-related changes of regional cerebral blood flow (rCBF) in man. This technique can correlate human cerebral anatomy with function. It is assumed that during the performance of a task (motor, visual, sensory, cognitive) the regions of the brain involved in its execution have increased metabolism and/or perfusion. rCBF is the best variable to measure such changes because it is highly correlated with the early phase of such elicited metabolic activity and its rapid assessment allows repetitive measurements. Thus, rCBF measurements in a control state and during the performance of a task are used to create specific images of changes in task-specific brain activity. Several studies have already been published about motor, sensory, visual, and cognitive activation and they contribute to our knowledge of functional mapping of the brain [6, 8].


Positron Emission Tomography Sensorimotor Cortex Positron Emission Tomography Camera Primary Sensorimotor Cortex rCBF Change 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Brodal A (1973) Self-observations and neuro-anatomical considerations after stroke. Brain 96:675–694PubMedCrossRefGoogle Scholar
  2. 2.
    Colebatch JG, Gandevia SC (1989) The distribution of muscular weakness in upper motor neuron lesions affecting the arm. Brain 112:749–763PubMedCrossRefGoogle Scholar
  3. 3.
    Friston KJ, Passingham RE, Nutt JG et al. (1989) Localisation in PET images: direct fitting of the intercommissural (AC-PC) line. J Cereb Blood Flow Metabol 9:690–696CrossRefGoogle Scholar
  4. 4.
    Jones RD, Donaldson IM, Parkin PJ (1989) Impairment and recovery of ipsilateral sensorymotor function following unilateral cerebral infarction. Brain 112:113–132PubMedCrossRefGoogle Scholar
  5. 5.
    Lammertsma AA, Cuningham VJ, Deiber MP et al. (1990) Combination of dynamic and integral methods for generating reproducible functional CBF images. J Cereb Blood Flow Metabol 10 (in press)Google Scholar
  6. 6.
    Lueck C, Zeki S, Friston KJ, Deiber MP et al. (1989) The colour centre in the cerebral cortex of man Nature 340:386–389PubMedCrossRefGoogle Scholar
  7. 7.
    Nyberg-Hansen R, Rinvik E (1963) Some comments on the pyramidal tract, with special reference to its individual variations in man. Acta Neurol Scand 39:1–30CrossRefGoogle Scholar
  8. 8.
    Petersen SE, Fox PT, Posner MI, Raichle ME (1988) Positron emission tomography studies of the cortical anatomy of single-word processing. Nature 331:585–589PubMedCrossRefGoogle Scholar
  9. 9.
    Powers WJ, Raichle ME (1985) Positron emission tomography and its application to the study of cerebrovascular disease in man. Stroke 16:361–376PubMedCrossRefGoogle Scholar
  10. 10.
    Roland PE, Larsen B, Lassen NA, Skinhoj E (1980) Supplementary motor area and other areas in organisation of voluntary movements in man. J Neurophysiol 43:118–136PubMedGoogle Scholar
  11. 11.
    Roland PE, Meyer E, Shibasaki T et al. (1982) Regional cerebral blood flow changes in cortex and basal ganglia during voluntary movements in normal human volunteers. J Neurophysiol 48:467–480PubMedGoogle Scholar
  12. 12.
    Sheikh K, Brennan PJ, Meade TW et al. (1983) Predictors of mortality and disability in stroke. J Epidemiol Community Health 37:70–74PubMedCrossRefGoogle Scholar
  13. 13.
    Skillbeck CE, Wade DT, Hewer RL, Wood VA (1983) Recovery after stroke. J Neurol Neurosurg Psychiatry 46:5–8CrossRefGoogle Scholar
  14. 14.
    Smith DL, Akthar AJ, Garraway WM (1985) Motor function after stroke. Age Aging 14:46–48CrossRefGoogle Scholar
  15. 15.
    Spinks TJ, Jones T, Gilardi MC, Heather JD (1988) Physical performance of the latest generation of commercial positron scanner. IEEE Trans Nucl Sci 35:721–725CrossRefGoogle Scholar
  16. 16.
    Talairach J, Tournoux P (1988) Co-planar stereotactic atlas of the human brain. Thieme, Stuttgart, 1988Google Scholar
  17. 17.
    Wiesendanger M (1981) The pyramidal tract: its structure and function. In: Towed AL, Lusher ES (eds) Handbook of behavioural neurobiology. Plenum, New York, pp 401–491Google Scholar
  18. 18.
    Yakolev PI, Rakic P (1966) Patterns of decussation of bulbar pyramids and distribution of pyramidal tracts on two sides of the spinal cord. Trans Am Neurol Assoc 91:366–367Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • F. Chollet
    • 1
    • 2
  • V. Di Piero
    • 1
  • R. J. S. Wise
    • 1
  • A. Rascol
    • 2
  • R. S. J. Frackowiak
    • 1
  1. 1.MRC Cyclotron UnitHammersmith HospitalLondonUK
  2. 2.Department of NeurologyHôpital PurpanToulouseFrance

Personalised recommendations