Neurochemical Changes in Brains from Patients with Vascular Dementia
Vascular dementia (VD) is usually assumed to be caused by infarctions of the brain. The etiology of multi-infarct dementia (MID) is discussed in Cummings and Benson . However, as far back as 1894, Alzheimer presented Die arteriosklerotische Atrophie des Gehirns . In this presentation, the concept of Binswanger’s disease and multi-infarctions was discussed, as was perivascular gliosis. Thus, in this early presentation of VD, not only infarcts, but also other substrates such as white matter and small vessel changes were regarded as pathogenetic factors.
KeywordsCaudate Nucleus Vascular Dementia Senile Plaque Neurochemical Change Parahippocampal Cortex
Unable to display preview. Download preview PDF.
- 2.Alafuzoff I (1985) Histopathological and immunocytochemical studies in age-associated dementias: the importance of rigorous histopathological criteria for classification of progressive dementia disorders. Doctoral thesis, Department of Pathology and Geriatric Medicine, University of UmeåGoogle Scholar
- 3.Alzheimer A (1894) Die arteriosklerotische Atrophie des Gehirns. Jahresversammlung des Vereins der Deutschen Irrenärzte zu Dresden, p 809Google Scholar
- 6.Cummings JC, Benson DF (1983) Dementia: a clinical approach. Butterworth, Boston, pp 137–140Google Scholar
- 14.Oreland L, Hiraga Y, Regland B, Gottfries CG (1989) Thrombocyte monoamine oxidase activity as a marker for Alzheimer’s disease. New vistas in drug research. Dialogues for the future. (Abstract) Symposuim 26–27 June 1989, MilanGoogle Scholar
- 17.Wallin A (1989) Vascular dementia-pathogenetic and clinical aspects. Doctoral thesis, Medical Faculty of University of GöteborgGoogle Scholar