Neurochemical Changes in Brains from Patients with Vascular Dementia
Vascular dementia (VD) is usually assumed to be caused by infarctions of the brain. The etiology of multi-infarct dementia (MID) is discussed in Cummings and Benson . However, as far back as 1894, Alzheimer presented Die arteriosklerotische Atrophie des Gehirns . In this presentation, the concept of Binswanger’s disease and multi-infarctions was discussed, as was perivascular gliosis. Thus, in this early presentation of VD, not only infarcts, but also other substrates such as white matter and small vessel changes were regarded as pathogenetic factors.
KeywordsCholesterol Ischemia Dopamine Dementia Nicotine
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