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CD5+ B Cells and Double-Negative T Cells in Rheumatoid Arthritis

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Rheumatoid Arthritis

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Abstract

The presence of autoantibodies such as rheumatoid factor (RF) in patients with rheumatoid arthritis (RA) prompted the concept that abnormalities in the immune system may be important in the development of the disease [70]. This in turn led to intensive studies on the cells involved and their interactions and homing to the site of local inflammation. In RA, the synovial membrane is characterized by the presence of lymphoid aggregates, local production of cytokines and secretion of immunoglobulins, of which a proportion shows autoantibody specificity (see Feldmann et al., this volume). In fact, the synovial membrane effectively functions as an ectopic lymphoid organ actively involved in an immune response.

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References

  1. Bergui L, Tesio L, Schena M, Riva M, Malavasi F, Schulz T, Marchision PC, Caligaris-Cappio F (1988) CD 5 and CD 21 molecules are a functional unit in the cell/substrate adhesion of B-chronic lymphocytic leukemia cells. Eur J Immunol 18:89–96

    Article  CAS  PubMed  Google Scholar 

  2. Boumsell L, Choppin H, Pham D, Raynall B, Lemerle J, Dausset J, Bernard A (1980) An antigen shared by a human T cell subset and B cell chronic lymphocytic leukemia cells. Distribution on normal and malignant lymphoid cells. J Exp Med 152:229–234

    Article  CAS  PubMed  Google Scholar 

  3. Brennan FM, Londei M, Jackson AM, Hercend T, Brenner MB, Maini RN, Feldmann M (1988) T cells expressing γδ chain receptors in rheumatoid arthritis. J Autoimmunity 1:319–326

    Article  CAS  Google Scholar 

  4. Brennan FM, Plater-Zyberk C, Feldmann M, Maini RN (1989) Coordinate expansion of ‘feotal type’ lymphocytes (TCR γδ T + and CD 5 + B) in rheumatoid arthritis and primary Sjogren’s syndrome. Clin Exp Immunol 77:175–178

    CAS  PubMed  Google Scholar 

  5. Brenner MB, Strominger JL, Krangel MS (1988) The γδ T cell receptor. Adv Immunol 34:133–192

    Article  Google Scholar 

  6. Brown CMS, Plater-Zyberk C, Mageed RA, Jefferis R, Maini RN (1990) Analysis of immunoglobulins secreted by hybridomas derived from rheumatoid synovia. Clin Exp Immunol 80:366–372

    Article  CAS  PubMed  Google Scholar 

  7. Budd RC, Schreyer M, Miescher C, MacDonald HR (1987) T cell lineages in the thymus of lpr/lpr mice: evidence for parallel pathways of normal and abnormal T cell development. J Immunol 139:2200–2210

    CAS  PubMed  Google Scholar 

  8. Burastero SE, Casali P (1989) Characterization of human CD5 (Leu-1)+B lymphocytes and the antibodies they produce. In: Del Guercio P, Cruse JM (eds) B lymphocytes: function and regulation. Contrib Microbiol Immunol, Karger, Basel 11:231–262

    Google Scholar 

  9. Cazenave PA, Martinez AC, Countinho A (1989) Differential L chain expression in the antibody response to phosphorylcholine of adult bone marrow or peritoneum-derived B lymphocytes. J Immunol 142:8–11

    CAS  PubMed  Google Scholar 

  10. Cavender D, Haskard D, Yu CL, Igushi T, Miossec P, Oppenheim-Marks N, Ziff M (1987) Pathways to chronic inflammation in rheumatoid synovitis. Fed Proc 46:113–117

    CAS  PubMed  Google Scholar 

  11. Dauphinee M, Yovar Z, Talal N (1988) B cells expressing CD 5 are increased in Sjogren’s syndrome. Arthritis Rheum 31:642–647

    Article  CAS  PubMed  Google Scholar 

  12. Erhardt CC, Mumford PA, Venables PJW, Maini RN (1989) Factors predicting a poor life prognosis in rheumatoid arthritis: an eight year prospective study. Ann Rheum Dis 48:7–13

    Article  CAS  PubMed  Google Scholar 

  13. Foster I, Rajewski K (1987) Expansion and functional activity of Ly-1+B cells upon transfer of peritoneal cells into allotype-congenic, newborn mice. Eur J Immunol 17:52–528

    Google Scholar 

  14. Fowlkes BJ, Kruisbeck AM, Ton-That H, Weston MA, Coligan JE, Schwartz RH, Pardoll DM (1988) A novel population of T-cell receptor aβ bearing thymocytes which predominantly express a single Vb gene family. Nature 329:251–254

    Article  Google Scholar 

  15. Freedman AS, Boyd AW, Bieber FR, Dayley J, Rosen K, Horowitz JC, Levy DN, Nadler LM (1987) Normal cellular counterparts of B cell chronic lymphocytic leukemia. Blood 70:418–427

    CAS  PubMed  Google Scholar 

  16. Gadol N, Ault K (1986) Phenotypic and functional characterization of human Leu 1 (CD 5) B cells. Immunol Rev 93:23–34

    Article  CAS  PubMed  Google Scholar 

  17. Gutierrez-Ramos JC, Andreu JL, Revilla Y, Vinuela E, Martinez-A C (1990) Recovery from autoimmunity of MRL/1pr mice after infection with an interleukin-2/vaccinia recombinant virus. Nature 346:271–274

    Article  CAS  PubMed  Google Scholar 

  18. Hale LP, Martin ME, McCollum DE, Nunley JA, Springer TA, Singer KH, Haynes BF (1989) Immunohistologic analysis of the distribution of the cell adhesion molecules within the inflammatory synovial microenvironment. Arthritis Rheum 32:22–30

    Article  CAS  PubMed  Google Scholar 

  19. Hara M, Atsushi K, Hirose T, Norioka K, Harigai M, Suzuki K, Tabata H, Kawakami M, Kawagoe M, Nakamura H (1988) Stimulatory effect of CD 5 antibody on B cells from patients with rheumatoid arthritis. Clin Immunol Immunopathol 49:223–230

    Article  CAS  PubMed  Google Scholar 

  20. Hardy RR, Hayakawa K, Shimizu M, Yamasaki K, Kishimoto T (1987) Rheumatoid factor secretion from human Leu-1 +B cells. Science 236:81–83

    Article  CAS  PubMed  Google Scholar 

  21. Hayakawa K, Hardy RR, Parks DR, Herzenberg LA (1983) The “Ly-1 B” cell subpopulation in normal immunodefective and autoimmune mice. J Exp Med 157:202–218

    Article  CAS  PubMed  Google Scholar 

  22. Hayakawa K, Hardy RR, Herzenberg LA, Herzenberg LA (1985) Progenitors for Ly-1 B cells are distinct from progenitors for other B cells. J Exp Med 161:1554–1568

    Article  CAS  PubMed  Google Scholar 

  23. Herzenberg LA, Stall AM, Lalor PA, Sidman C, Moore WA, Parks DR (1986) The Ly-1 B cell lineage. Immunol Rev 93:81–102

    Article  CAS  PubMed  Google Scholar 

  24. Holoshitz J, Klamjma A, Drucker I, Lapidot Z, Yaretzky A, Van Eden W, Cohen IR (1986) T lymphocytes or rheumatoid arthritis patients show reactivity to a fraction of mycobacteria cross-reactive with cartilage. Lancet ii: 305–309

    Article  Google Scholar 

  25. Holoshitz J, Koning F, Je De Bruyn J, Strober S (1989) Isolation of CD4–CD8-mycobacteria-reactive T lymphocyte clones from rheumatoid arthritis synovial fluid. Nature 339:226–229

    Article  CAS  PubMed  Google Scholar 

  26. Humphries GC, Shen A, Kuziel WA, Capra JD, Blattner FR, Tucker PW (1988) A new human immunoglobulin VH family preferentially rearranged in immature B-cell tumors. Nature 331:446–449

    Article  CAS  PubMed  Google Scholar 

  27. Iwatani Y, Amino N, Kaneda T, Ichihara K, Tamaki H, Tachi J, Matsuzuka F, Fukata S, Kuma K, Miyai K (1989) Marked increase of CD5+B cells in hyperthyroid Graves’ disease. Clin Exp Immunol 78:196–200

    CAS  PubMed  Google Scholar 

  28. Janis EM, Kaufmann SHE, Schwartz RH, Pardoll DM (1989) Activation of γδ T cells in the primary immune response to Mycobacterium tuberculosis. Science 244:713–716

    Article  CAS  PubMed  Google Scholar 

  29. Jones NH, Clabby ML, Dialynas DH, Huang HJ, Herzenberg LA, Strominger J (1986) Isolation of complementary DNA clones encoding the human lymphocyte glycoprotein T1/Leu-1. Nature 323:346–349

    Article  CAS  PubMed  Google Scholar 

  30. Kappler JW, Staerz U, White J, Marrack P (1988) Self tolerance eliminates T cells specific for Mis-modified products of the major histocompatibility complex. Nature 332:35–40

    Article  CAS  PubMed  Google Scholar 

  31. Kearney JF, Vakil M, Solvason N (1989) The role of idiotypic interactions and B-cell subsets in development of the B-cell repertoire. Cold Spring Harbor Symp Quant Biol LIV: 23–207

    Google Scholar 

  32. Kennedy TD, Plater-Zyberk C, Partridge TA, Woodrow DF, Maini RN (1988) Morphometric comparison of synovium from patients with osteoarthritis and rheumatoid arthritis. J Clin Pathol 41:847–852

    Article  CAS  PubMed  Google Scholar 

  33. Kipps TJ, Vaughan JH (1987) Genetic influence on the levels of circulating CD5 B lymphocytes. J Immunol 139:1060–1064

    CAS  PubMed  Google Scholar 

  34. Kipps TJ, Tomhave E, Chen PP, Carson D (1988) Autoantibody-associated kappa light chain variable region gene expressed in chronic lymphocytic leukemia with little or no somatic mutation. J Exp Med 167:840–852

    Article  CAS  PubMed  Google Scholar 

  35. Kipps TJ (1990) The CD5 B cell. Adv Immunol 47:117–185

    Article  Google Scholar 

  36. Kipps TJ, Robbins BA, Carson DA (1990) Uniform high frequency expression of autoantibody-associated crossreactive idiotypes in the primary B cell follicles of human fetal spleen. J Exp Med 171:189–196

    Article  CAS  PubMed  Google Scholar 

  37. Kissonerghis AM, Maini RN, Feldmann M (1989) High rate of HLA class II mRNA synthesis in rheumatoid arthritis joints and its persistence in culture: down-regulation by recombinant interleukin 2. Scand J Immunol 29:73–82

    Article  CAS  PubMed  Google Scholar 

  38. Lanier LL, Ruitenberg J, Bolhuis RLH, Borst J, Phillips JH, Testi R (1988) Structural and serological heterogeneity of γδ T cell antigen receptor expression in thymus and peripheral blood. Eur J Immunol 18:1873–2112

    Article  Google Scholar 

  39. Londei M, Savill C, Verhoef A, Brennan F, Leech ZA, Duance V, Maini RN, Feldmann M (1989) Persistence of collagen type II specific T cell clones in the synovial membrane of a patient with RA. Proc Natl Acad Sci 8:636–640

    Article  Google Scholar 

  40. Maini RN, Plater-Zyberk C, Andrew E (1987) Autoimmunity in rheumatoid arthritis. An approach via the study of B lymphocytes. In: Zvaifler N, Saunders WB (eds) Pathogenesis of chronic inflammatory arthritis. Rheum Dis Clin North Am 13:319–337

    Google Scholar 

  41. Maini RN, Plater-Zyberk C (1988) The significance of CD5+B cells in rheumatic diseases. Scand J Rheumatology 76 (suppl): 237–242

    Article  CAS  Google Scholar 

  42. Marcos MA, de le Hera A, Pereira P, Marquez C, Toribio M, Coutinho A, Martinez C (1988) B cell participation in the recursive selection of T cell repertoires. Eur J Immunol 18:1015–1020

    Article  CAS  PubMed  Google Scholar 

  43. Martinez-A C, Bernabe R, de la Hera A, Pereira P, Cazenave P-A, Coutinho A (1985) Establishment of idiotypic helper T-cell repertoires early in life. Nature 317:721–723

    Article  CAS  PubMed  Google Scholar 

  44. Martinez C, Pereira P, de la Hera A, Bandeira A, Marquez C, Coutinho A (1986) The basis for major histocompatibility complex (MHC) and immunoglobulin gene control of helper T cell idiotopes. Eur J Immunol 16:417–422

    Article  Google Scholar 

  45. Masmoudi H, Motas-Santos, Huetz F, Coutinho A, Cazenave P-A (1990) All T15 Id-positive antibodies (but not the majority of VH T15+ antibodies) are produced by peritoneal CD5+B lymphocytes. International Immunol 2:515–520

    Article  CAS  Google Scholar 

  46. Mayer R, Logtenberg T, Strauchen J, Dimitriu-Bona A, Mayer L, Mechanic S, Chiorazzi N, Borche L, Dighiero G, Mannheimer-Lory A, Diamond B, Alt F, Bona C (1990) CD5 and immunoglobulin V gene expression in B-cell lymphomas and chronic lymphocytic leukemia. Blood 75:1518–1524

    CAS  PubMed  Google Scholar 

  47. Mercolino TJ, Arnold LW, Hawkins LA, Haughton G (1988) Normal mouse peritoneum contains a large population of Ly-1+ (CD 5) B cells that recognize phosphatidylcholine. Relationship to cells that secrete hemolytic antibody specific for autologous erythrocytes. J Exp Med 168:687–698

    Article  CAS  PubMed  Google Scholar 

  48. Mix E, Olsson T, Correale J, Baig S, Kostulas V, Olsson O, Link H (1990) B cells expressing CD5 are increased in cerebrospinal fluid of patients with multiple sclerosis. Clin Exp Immunol 79:21–27

    Article  CAS  PubMed  Google Scholar 

  49. Moingeon P, Ythier A, Goubin G, Faure F, Nowill A, Delmon L, Rainaud M, Forestier F, Daffos F, Bohuon C, Hercend T (1986) A unique T cell receptor complex expressed on human foetal lymphocytes displaying natural-killer like activity. Nature 323:638–640

    Article  CAS  PubMed  Google Scholar 

  50. Nicoletti F, Meroni PL, Barcellini W, Steinvag PO, di Mauro M, Lunetta M, Pagano M, Consoli U, Zanussi C (1990) Enhanced percentage of CD5+B lymphocytes in newly diagnosed IDDM patients. Immunol Lett 23:211–215

    Article  CAS  PubMed  Google Scholar 

  51. Nishimura Y, Bierer BE, Burakoff SJ (1988) Expression of CD5 regulates responsiveness to IL-1. J Immunol 141:3438–3444

    CAS  PubMed  Google Scholar 

  52. Perlmutter RM, Kearney JF, Chang SP, Hood LE (1985) Developmentally controlled expression of immunoglobulin VH genes. Science 227:1597–1601

    Article  CAS  PubMed  Google Scholar 

  53. Pitzalis C, Kingsley G, Murphy J, Panayi G (1987) Abnormal distribution of the helper-inducer and suppressor-inducer T lymphocyte subsets in the rheumatoid joint. Clin Immunol Immunopathol 45:252–258

    Article  CAS  PubMed  Google Scholar 

  54. Plater-Zyberk C, Maini RN, Lam K, Kennedy TD, Janossy G (1985) A rheumatoid arthritis B cell subset express a phenotype similar to that in chronic lymphocytic leukemia. Arthritis Rheum 28:971–976

    Article  CAS  PubMed  Google Scholar 

  55. Plater-Zyberk C, Maini RN (1988) Phenotypic and functional features of CD5+B lymphocytes in rheumatid arthritis. Scand J Rheumatology 75 (suppl):76–83

    Article  CAS  Google Scholar 

  56. Plater-Zyberk C, Brennan FM, Feldmann M, Maini RN (1989) ‘Foetal-type’ B and T lymphocytes in rheumatoid arthritis and primary Sjogren’s syndrome. J Autoimmun 2 (suppl):233–241

    Article  PubMed  Google Scholar 

  57. Plater-Zyberk C, Brown CMS, Mageed RA, Jefferis R, Maini RN (1990) B cell hybridomas derived from rheumatoid synovium express CD5 antigen and cross-reactive idiotypes. to be published

    Google Scholar 

  58. Porcelli S, Brenner MB, Greenstein JL, Balk SP, Terhorst C, Bleicher PA (1989) Recognition of cluster antigens by human CD4–CD8-cytolytic T lymphocytes. Nature 341:447–450

    Article  CAS  PubMed  Google Scholar 

  59. Raulet DH (1989) The structure, function and molecular genetics of the γδ T cell receptor. Ann Rev Immunol 7:175–207

    Article  CAS  Google Scholar 

  60. Reme T, Portier M, Frayssinoux F, Combe B, Miossec P, Favier F, Sany J (1990) T cell receptor expression and activation of synovial lymphocyte subsets in patients with rheumatoid arthritis. Phenotyping of multiple synovial sites. Arthritis Rheum 33:485–492

    Article  CAS  PubMed  Google Scholar 

  61. Sanz I, Casali P, Thomas JW, Notkins AL, Capra D (1989) Nucleotide sequences of eight human natural autoantibody VH regions reveal apparent restricted use of VH families. J Immunol 142:4054–4061

    CAS  PubMed  Google Scholar 

  62. Schroeder HW Jr, Hillson JL, Perlmutter RM (1987) Early restriction of the human antibody repertoire. Science 238:791–793

    Article  CAS  PubMed  Google Scholar 

  63. Schroeder HW Jr, Wang JY (1990) Preferential utilization of conserved immunoglobulin heavy chain variable gene segments during fetal life. Proc Natl Acad Sci USA 87:614–6150

    Google Scholar 

  64. Shivakumar S, Tsokos GC, Datta SK (1989) T cell receptor αβ expressing double-negative (CD4-/CD8-) and CD 4+T helper cells in humans augment the production of pathogenic anti-DNA autoantibodies associated with lupus nephritis. J Immunol 143:103–112

    CAS  PubMed  Google Scholar 

  65. Strominger JL (1989) The γδ T-cell receptor and class 1b MHC-related proteins: enigmatic molecules of immune recognition. Cell 57:875–898

    Article  Google Scholar 

  66. Suranyi P, Szegedi G, Damjanovich S, Juhasz F, Stenszky V, Farid NR (1989) B lymphocytes in Hashimoto’s thyroiditis. Immunol Lett 22:147–150

    Article  CAS  PubMed  Google Scholar 

  67. Taniguchi O, Miyajima H, Hirano T, Noguchi M, Ueda A, Hashimoto H, Hirose S, Okumura K (1987) The Leu-1 B cell subpopulation in patients with rheumatoid arthritis. J Clin Immunol 7:441–448

    Article  CAS  PubMed  Google Scholar 

  68. Tarkowski A, Klareskog L, Carlsten H, Herbets P, Koopman W (1989) Secretion of antibodies to type I and II collagen by synovial tissue cells in patients with rheumatoid arthritis. Arthritis Rheum 32:1087–1092

    Article  CAS  PubMed  Google Scholar 

  69. Vakil M, Kearney JF (1986) Functional characterization of monoclonal autoanti-idiotype antibodies from early B cell repertoire. Eur J Immunol 16:1159–1165

    Article  CAS  PubMed  Google Scholar 

  70. Waaler E (1945) On the occurrence of a factor in human serum activating the specific agglutination of sheep blood corpuscules. Acta Pathol Microbiol Scand 17:172–178

    Article  Google Scholar 

  71. Yamada H, Shimizu H, Taniguchi O, Okumura K (1988) Leu-1 (CD5) B cell subpopulation in patients with various liver diseases, special reference to hepatitis B virus carrier and to changes caused by prednisolone therapy. Int Arch Allergy Appl Immunol 87:409–416

    Article  CAS  PubMed  Google Scholar 

  72. Youinou P, Mackenzie L, Katsikis P, Merdrignac DA, Isenberg DA, Tuallon N, Lamour A, Ie Goff P, Jouquan J, Drogou A, Muller B, Moutsopoulos HM, Lydyard PM (1990) The relationship between CD 5 expressing B lymphocytes and serological abnormalities in rheumatoid arthritis patients and their relatives. Arthritis Rheum 33:339–348

    Article  CAS  PubMed  Google Scholar 

  73. Ziff M (1989) Role of endothelium in chronic inflammation. Springer Sem Immunopathol 11:199–214

    CAS  Google Scholar 

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Authors and Affiliations

  1. Kennedy Institute of Rheumatology, 6 Bute Gardens, London, W67DW, UK

    C. Plater-Zyberk & R. N. Maini

  2. Charing Cross Sunley Research Centre, Lurgan Avenue, London, W6 8LW, UK

    F. M. Brennan & M. Feldmann

Authors
  1. C. Plater-Zyberk
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  2. R. N. Maini
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  3. F. M. Brennan
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  4. M. Feldmann
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Editors and Affiliations

  1. 2. Medizinische Abteilung Zentrum fü Diagnostik und Therapie rheumatischer Erkrankungen, Krankenhaus der Stadt Wien-Lainz und Ludwig Boltzmann Institut für Rheumatologie und Balneologie, Wolkersbergenstraße 1, A-1130, Wien, Austria

    Josef S. Smolen

  2. Medizinische Klinik III mit Poliklinik und Institut für Klinische Immunologie und Rheumatologie, Friedrich-Alexander-Universität Erlangen-Nürnberg, Krankenhausstraße 12, W-8520, Erlangen, Germany

    Joachim R. Kalden

  3. Mathilda and Terence Kennedy Institute of Rheumatology, 6 Bute Gardens, W6 7DW, Hammersmith, London, UK

    Ravinder N. Maini

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Plater-Zyberk, C., Maini, R.N., Brennan, F.M., Feldmann, M. (1992). CD5+ B Cells and Double-Negative T Cells in Rheumatoid Arthritis. In: Smolen, J.S., Kalden, J.R., Maini, R.N. (eds) Rheumatoid Arthritis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76189-8_9

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  • DOI: https://doi.org/10.1007/978-3-642-76189-8_9

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