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Role of Cellular Adhesion in Rheumatoid Synovitis

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Book cover Rheumatoid Arthritis

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Abstract

The basis for rheumatoid synovitis is a cellular immune response in the sublining tissue of the rheumatoid synovial membrane (RSM). As a consequence of this reaction, cytokines and growth factors are released which mediate a nonspecific amplification of the initial inflammatory focus, proliferation of the synovial tissue, and immunoglobulin and rheumatoid factor synthesis.

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Authors and Affiliations

  1. The University of Texas Southwestern Medical Center, Dallas, Texas, USA

    M. Ziff

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  1. M. Ziff
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Editors and Affiliations

  1. 2. Medizinische Abteilung Zentrum fü Diagnostik und Therapie rheumatischer Erkrankungen, Krankenhaus der Stadt Wien-Lainz und Ludwig Boltzmann Institut für Rheumatologie und Balneologie, Wolkersbergenstraße 1, A-1130, Wien, Austria

    Josef S. Smolen

  2. Medizinische Klinik III mit Poliklinik und Institut für Klinische Immunologie und Rheumatologie, Friedrich-Alexander-Universität Erlangen-Nürnberg, Krankenhausstraße 12, W-8520, Erlangen, Germany

    Joachim R. Kalden

  3. Mathilda and Terence Kennedy Institute of Rheumatology, 6 Bute Gardens, W6 7DW, Hammersmith, London, UK

    Ravinder N. Maini

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© 1992 Springer-Verlag Berlin Heidelberg

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Ziff, M. (1992). Role of Cellular Adhesion in Rheumatoid Synovitis. In: Smolen, J.S., Kalden, J.R., Maini, R.N. (eds) Rheumatoid Arthritis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76189-8_5

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  • DOI: https://doi.org/10.1007/978-3-642-76189-8_5

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