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Rheumatoid Arthritis pp 348–362Cite as

Markers of Cartilage Destruction

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Abstract

Progressive destruction of the normal architecture of the joint is a hallmark of chronic joint diseases such as rheumatoid arthritis and osteoarthritis. Cartilage and juxta-articular bone are degraded, resulting in functional impairment and disability. However, progressive destruction does not always occur. Therefore, it is desirable to identify patients at risk for developing severe joint damage as candidates for early aggressive but also toxic drug therapy in selected cases [1]. Biochemical markers of disease activity in routine use primarily reflect inflammation, which is not necessarily linked to the destructive process [2]. Therefore, levels of inflammatory markers are usually not suitable for monitoring tissue destruction. Radiography can be used only to show late events in the process, since when changes are visible on radiograms the damage at the molecular level is already advanced. Treatment at this stage may be too late to affect the destructive process. These limiations in the currently used measures also reduce the possibility of identifying the beneficial effects of new drugs on joint destruction.

T. S. is presently the recipient of a research grant from the German Center for Rheumatic Research in Berlin

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Author information

Authors and Affiliations

  1. Department of Rheumatology, Lund University Hospital, Lund, Sweden

    F. A. Wollheim (Professor and Chairman)

  2. Department of Rheumatology and Department of Physiological Chemistry, University of Lund, Sweden

    T. Saxne

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  1. F. A. Wollheim
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  2. T. Saxne
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Editor information

Editors and Affiliations

  1. 2. Medizinische Abteilung Zentrum fü Diagnostik und Therapie rheumatischer Erkrankungen, Krankenhaus der Stadt Wien-Lainz und Ludwig Boltzmann Institut für Rheumatologie und Balneologie, Wolkersbergenstraße 1, A-1130, Wien, Austria

    Josef S. Smolen

  2. Medizinische Klinik III mit Poliklinik und Institut für Klinische Immunologie und Rheumatologie, Friedrich-Alexander-Universität Erlangen-Nürnberg, Krankenhausstraße 12, W-8520, Erlangen, Germany

    Joachim R. Kalden

  3. Mathilda and Terence Kennedy Institute of Rheumatology, 6 Bute Gardens, W6 7DW, Hammersmith, London, UK

    Ravinder N. Maini

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© 1992 Springer-Verlag Berlin Heidelberg

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Wollheim, F.A., Saxne, T. (1992). Markers of Cartilage Destruction. In: Smolen, J.S., Kalden, J.R., Maini, R.N. (eds) Rheumatoid Arthritis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76189-8_23

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  • DOI: https://doi.org/10.1007/978-3-642-76189-8_23

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