The Antiperinuclear Factor (APF) and Antikeratin Antibodies (AKA) in Rheumatoid Arthritis

  • R. M. Hoet
  • W. J. van Venrooij


The diagnosis of rheumatoid arthritis (RA) is first of all based on clinical manifestations. Serological support for such a diagnosis is not very well established and it is based mainly on the presence of rheumatoid factors (RF). A positive RF test has a predictive value [1] and is related to disease with a more severe outcome [2]. However, RF is also present in other (autoimmune) diseases and in control sera from healthy persons [3]. Therefore, testing for a second RA-specific antibody would be very useful, and might even be necessary for the management of seronegative RA patients.


Rheumatoid Arthritis Patient Stratum Corneum Keratohyalin Granule Rheumatoid Arthritis Seron Buccal Mucosa Cell 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • R. M. Hoet
    • 1
  • W. J. van Venrooij
    • 1
  1. 1.Department of BiochemistryUniversity of NijmegenNijmegenThe Netherlands

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