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Are Retroviruses Involved in the Pathogenesis of Autoimmune Diseases?

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Book cover Rheumatoid Arthritis

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Abstract

Large portions of mammalian genomes consist of DNA sequences originally derived from retroviruses during ontogenesis. The majority of these retroviral sequences are non-infectious. However, during the past few years, evidence has been gained for the hypothesis that retroviral sequences or their products might play a role in the pathogenesis of autoimmune diseases (Table 1). The question

Table 1 Indications for retroviruses in autoimmune diseases
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Table 2 Immunologic features in HIV 1-infected persons (modified from [54])
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Table 3 Rheumatic manifestations of human immunodeficiency virus infection (according to [10a])
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now arises whether newly discovered infectious retroviruses might induce autoimmune diseases. Many autoimmune features of HIV 1 infection point to this possibility (Table 2, 3).

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Author information

Authors and Affiliations

  1. Institute of Clinical Immunology and Rheumatology, Department of Internal Medicine III, Friedrich Alexander University Erlangen-Nürnberg, Krankenhausstrasse 12, W-8530, Erlangen, Germany

    E. F. Krapf

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  1. E. F. Krapf
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Editors and Affiliations

  1. 2. Medizinische Abteilung Zentrum fü Diagnostik und Therapie rheumatischer Erkrankungen, Krankenhaus der Stadt Wien-Lainz und Ludwig Boltzmann Institut für Rheumatologie und Balneologie, Wolkersbergenstraße 1, A-1130, Wien, Austria

    Josef S. Smolen

  2. Medizinische Klinik III mit Poliklinik und Institut für Klinische Immunologie und Rheumatologie, Friedrich-Alexander-Universität Erlangen-Nürnberg, Krankenhausstraße 12, W-8520, Erlangen, Germany

    Joachim R. Kalden

  3. Mathilda and Terence Kennedy Institute of Rheumatology, 6 Bute Gardens, W6 7DW, Hammersmith, London, UK

    Ravinder N. Maini

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© 1992 Springer-Verlag Berlin Heidelberg

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Krapf, E.F. (1992). Are Retroviruses Involved in the Pathogenesis of Autoimmune Diseases?. In: Smolen, J.S., Kalden, J.R., Maini, R.N. (eds) Rheumatoid Arthritis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76189-8_17

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  • DOI: https://doi.org/10.1007/978-3-642-76189-8_17

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  • Print ISBN: 978-3-642-76191-1

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