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Urothelial Atypia and Dysplasia

  • F. Hofstädter

Abstract

Histopathology has long recognized “flat” lesions of the urothelium, a certain percentage of which are missed by gross examination. These lesions may occur in isolation or as an accompaniment to overt inflammatory or neoplastic disease. In this article we shall discuss only those lesions that bear a distinct relationship to urothelial cancer. These flat “preneoplastic” or early neoplastic changes are of major clinical and biologic significance, and they hold the key to understanding the behavior of urothelial carcinomas and their cytologic classification.

Keywords

Urothelial Carcinoma Atypical Hyperplasia Urothelial Cancer Visible Tumor Superficial Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Barlebo H, Sorensen BL, Ohlsen AS (1972) Carcinoma in situ of the urinary bladder: flat intraepithelial neoplasia. J Urol Nephrol 6: 213–223CrossRefGoogle Scholar
  2. Bergkvist A, Ljungquist A, Moberger G (1965) Classification of bladder tumours based on the cellular pattern. Acta Chir Scand 130: 371–378PubMedGoogle Scholar
  3. Eisenberg RB, Roth RB, Weinberg ME (1960) Bladder tumors and associated proliferative mucosal lesions. J Urol 84: 544–550PubMedGoogle Scholar
  4. Farrow GM, Utz DC, Rife CC, Greene LF (1977) Clinical observations on sixty-nine cases of in situ carcinoma of the urinary bladder. Cancer Res 37: 2794–2798PubMedGoogle Scholar
  5. Farsund T, Laerum OD, Hostmark J (1983) Ploidie disturbance of normal appearing bladder mucosa in patients with urothelial cancer; relationship to morphology. J Urol 130: 1076–1082PubMedGoogle Scholar
  6. Hofstädter F, Jakse G, Lederer B, Mikuz G, Delgado R (1984) Biological behaviour and DNA-Feulgen-Cytophotometry of urothelial bladder carcinoma. Br J Urol 56: 289–295CrossRefGoogle Scholar
  7. Hofstädter F, Delgado R, Jakse G, Judmaier W (1986) Urothelial dysplasia and carcinoma in situ of the bladder. Cancer 57: 356–361PubMedCrossRefGoogle Scholar
  8. Jakse G, Hofstädter F, Leitner G, Marberger H (1980) Carcinoma in situ der Harnblase. Eine diagnostische und therapeutische Herausforderung. Urologe [A] 19: 93–99Google Scholar
  9. Jakse G, Hufnagel B, Hostädter F, Rubben H (1986) Sequentielle Blasenschleimhautbiopsie beim Urothelkarzinom der Harnblase. Verh Dtsch Ges Urol 37: 200–201Google Scholar
  10. Jakse G, Putz A, Hofstädter F (1987) Carcinoma in situ of the urinary bladder extending into the seminal vesicles. J Urol 137: 44–45PubMedGoogle Scholar
  11. Koss LG, Melamed MR, Kelly RE (1969) Further cytologic and histologic studies of bladder lesions in workers exposed to para-aminodiphenyl: progress report. J Natl Cancer Inst 43: 233–243PubMedGoogle Scholar
  12. Koss LG, Nakanishi I, Freed SZ (1977) Nonpapillary carcinoma in situ and atypical hyperplasia in cancerous bladders. Urology 9: 443–455CrossRefGoogle Scholar
  13. Melamed MR, Voutsa NG, Grabstald H (1964) Natural history and clinical behaviour of in situ carcinoma of the human urinary bladder. Cancer 17: 1533–1545PubMedCrossRefGoogle Scholar
  14. Melicow MM (1952) Histological study of vesical urothelium intervening between gross neoplasms in total cystectomy. J Urol 68: 261–279PubMedGoogle Scholar
  15. Mostofi FK, Davies CJ Jr, Sesterhenn IA (1988) Pathology of tumors of urinary tract. In: Steinner DG, Leikovsky G (eds) Diagnosis and management of genito-urinary cancer. Saunders, PhiladelphiaGoogle Scholar
  16. Murphy WM, Soloway MS (1982) Urothelial dysplasia. J Urol 127: 849–854PubMedGoogle Scholar
  17. Prout GR, Griffin PP, Daly JJ, Heney NM (1983) Carcinoma in situ of the urinary bladder with and without associated vesical neplasms. Cancer 52: 524–532PubMedCrossRefGoogle Scholar
  18. Riddle PR, Chisholm GD, Trott PA, Pugh RC (1975) Flat carcinoma in situ of the bladder. Br J Urol 47: 829–833PubMedCrossRefGoogle Scholar
  19. Schade ROK, Swinney J (1968) Pre-cancerous changes in bladder epithelium. Lancet 2: 943–946PubMedCrossRefGoogle Scholar
  20. Soloway MS, Murphy W, Rao MK, Cox C (1978) Serial multiple biopsies in patients with bladder cancer. J Urol 120: 57–59PubMedGoogle Scholar
  21. Soto EA, Friedeil GH (1977) Bladder cancer as seen in giant histologic sections. Cancer 39: 447–455PubMedCrossRefGoogle Scholar
  22. Wolf H, Hojgaard K (1983) Urothelial dysplasia concominant with bladder tumours as a determinant factor for future new occurences. Lancet 2: 134–136PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • F. Hofstädter

There are no affiliations available

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