Interstitial Irradiation of Supratentorial Cerebral Gliomas in Childhood with Permanently Implanted Iodine 125: Preliminary Results

  • J. Voges
  • H. Treuer
  • W. J. Schlegel
  • O. Pastyr
  • V. Sturm
Conference paper
Part of the Advances in Neurosurgery book series (NEURO, volume 19)

Abstract

Local cure of a cerebral glioma by surgery alone is often precluded by the invasion of tumor cells into surrounding macroscopically healthy brain tissue. In patients with brainstem gliomas, which account for 10%–25% of all intracranial neoplasms in children [5], cerebral areas are involved which are functionally more or less impossible.

Keywords

Iodine Shrinkage Oncol Dexamethasone Neurol 

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References

  1. 1.
    Bauer-Kirpes B, Sturm V, Schlegel W. Lorenz WJ (1988) Computerized optimization of 125–1 implants in brain tumors. Int J Radiat Oncol Biol Phys 14:1013–1023PubMedCrossRefGoogle Scholar
  2. 2.
    Ehrlich SS, Davis RL (1978) Spinal subarachnoid metastasis from primary intracranial glioblastoma multiforme. Cancer 42:2854–2864CrossRefGoogle Scholar
  3. 3.
    Eifel PJ, Cassady JR, Belli JA (1987) Radiation therapy of tumors of the brainstem and midbrain in children: experience of the Joint Center for Radiation Therapy and Children’s Hospital Medical Center (1971–1981). Int J Radiat Oncol Biol Phys 13:847–952PubMedCrossRefGoogle Scholar
  4. 4.
    Etou A, Mundinger F, Mohadjer M, Birg W (1989) Stereotactic interstitial irradiation of diencephalic tumors with iridium 192 and iodine 125: 10 years follow-up and comparison with other treatments. Childs Nerv Syst 5:140–143PubMedCrossRefGoogle Scholar
  5. 5.
    Farwell JR, Dohrmann GJ, Flannery JT (1977) Central nervous system tumors in children. Cancer 40:3123–3132PubMedCrossRefGoogle Scholar
  6. 6.
    Freeman CR, Suissa S (1986) Brain stem tumors in children: results of a survey of 62 patients treated with radiotherapy. Int J Radiat Oncol Biol Phys 12:1823–1828PubMedCrossRefGoogle Scholar
  7. 7.
    Hall EJ (1978) Radiobiology for the radiologist, 2nd edn. Harper and Row, Hager-stown/MarylandGoogle Scholar
  8. 8.
    Halperin EC, Wehn St M, Scott JW, Djang W, Oakes WJ, Friedman HS (1989) Selection of a management strategy for pediatric brainstem tumors. Med Pediatr Oncol 17:116–125CrossRefGoogle Scholar
  9. 9.
    Hochberg FA, Pruitt A (1980) Assumptions in the radiotherapy of glioblastomas. Neurology 30:907–911PubMedGoogle Scholar
  10. 10.
    Hoshino T, Barker M, Wilson CB, Boldrey EB, Fewer D (1972) Cell kinetics of human gliomas. J Neurosurg 37:15–26PubMedCrossRefGoogle Scholar
  11. 11.
    Hoshino T, Rodriguez LA, Cho KG, Lee KS, Wilson CB, Edward MSB, Levin VA, Davis RL (1988) Prognostic implications of the proliferative potential of low grade astrocytomas. J Neurosurg 69:839–842PubMedCrossRefGoogle Scholar
  12. 12.
    Kaplan EL, Meier P (1958) Nonparametric estimation from incomplete observations. J Am Statist Assoc. 53:457–481CrossRefGoogle Scholar
  13. 13.
    Kamofsky DA, Abelmann WH, Carver LF, Burchenal JH (1948) The use of nitrogen mustards in the palliative treatment of carcinoma with particular reference to bronchogenic carcinoma. Cancer 1:634–656CrossRefGoogle Scholar
  14. 14.
    Kernohan JW, Mabon RF, Svien HJ, Adson AW (1949) A simplified classification of the gliomas. Proc Mayo Clin 24:71–75PubMedGoogle Scholar
  15. 15.
    Mundinger F (1966) The treatment of brain tumors with radioisotopes. Prog Neurol Surg 1:220–257Google Scholar
  16. 16.
    Schlegel WJ, Scharfenberg H, Sturm V, Penzholz H, Lorenz WJ (1981) Direct visualization of intracranial tumours in stereotactic and angiographic films by computer calculation of longitudinal CT-sections: a new method for stereotactic localization of tumor outlines. Acta Neurochir (Wien) 58:27–35CrossRefGoogle Scholar
  17. 17.
    Szikla G, Peragut JC (1984) Irradiation interstitielle des gliomes. Neurochirurgie 21 [Suppl 2]: 187–228Google Scholar
  18. 18.
    Sturm V, Pastyr O, Schlegel W, Scharfenberg H, Zabel HJ, Netzeband G, Schabbert S, Berberich W (1983) Stereotactic computer tomography with a modified Riechert Mundinger device as the basis for integrated stereotactic neuroradiological investigations. Acta Neurochir (Wien) 68:11–17CrossRefGoogle Scholar
  19. 19.
    Wara WM (1985) Radiation therapy for brain tumors. Cancer 55:2291–2295PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • J. Voges
  • H. Treuer
  • W. J. Schlegel
  • O. Pastyr
  • V. Sturm
    • 1
  1. 1.Abteilung für Stereotaxie und funktionelle NeurochirurgieNeurochirurgische Universitätsklinik KölnKöln 41Germany

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