S-100-Related Proteins in Nerve Growth Factor-Induced Differentiation of PC12 Cells
In the development of the nervous system, more neurons are generated than are eventually found in the adult organism. The mechanisms which determine the selective neuronal survival, the acquisition and maintenance of the differentiated phenotype, and the potential for regeneration are presently under intensive study. The pioneering work on nerve growth factor (NGF) and, more recently, also other polypeptide factors, has established the key role of target-derived neurotrophic substances in these processes (for recent review, see Snider and Johnson 1989). Much effort is now focused on understanding the molecular mechanisms triggered by the interaction of neurotrophic factors with their neuronal receptors.
KeywordsArthritis Tyrosine Leukemia Agarose Cysteine
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- Ebralidze A, Tulchinsky E, Grigorian M, Afanasyeva A, Senin V, Revazova E, Lukanidin E (1989) Isolation and characterization of a gene specifically expressed in different metastatic cells and whose deduced gene product has a high degree of homology to a Ca2+-binding protein family. Genes Dev 3:1086–1093.PubMedCrossRefGoogle Scholar
- Koike T, Martin DP, Johnson EM (1989) Role of Ca2+ channels in the ability of membrane depolarization to prevent neuronal death induced by the trophic-factor deprivation: evidence that levels of internal Ca2+ determine nerve growth factor dependence of sympathetic ganglion cells. Proc Natl Acad Sci USA 86:6421–6425.PubMedCrossRefGoogle Scholar
- Masiakowski P, Shooter EM (1990) Changes in PC12 cell morphology induced by transfection with 42C DNA, a member of the S-100 family. J Neurosci Res (in press).Google Scholar