S-100-Related Proteins in Nerve Growth Factor-Induced Differentiation of PC12 Cells
In the development of the nervous system, more neurons are generated than are eventually found in the adult organism. The mechanisms which determine the selective neuronal survival, the acquisition and maintenance of the differentiated phenotype, and the potential for regeneration are presently under intensive study. The pioneering work on nerve growth factor (NGF) and, more recently, also other polypeptide factors, has established the key role of target-derived neurotrophic substances in these processes (for recent review, see Snider and Johnson 1989). Much effort is now focused on understanding the molecular mechanisms triggered by the interaction of neurotrophic factors with their neuronal receptors.
KeywordsPC12 Cell Nerve Growth Factor Rous Sarcoma Virus Nerve Growth Factor Action Nerve Growth Factor Response
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