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Diversity in the Annexin Family

  • Stephen E. Moss
  • Helena C. Edwards
  • Michael J. Crumpton

Abstract

The discovery in recent years of a major novel family of calcium-binding proteins, most commonly known as the lipocortin or calpactin family, has brought together several diverse areas of interest. One consequence of this, has been the generation of a cumbersome and confusing nomenclature, creating problems even for those working directly in the field. In this chapter we begin by attempting to clarify the nomenclature, adopting the generic name annexin together with the numbering system first applied to the lipocortins (Crumpton and Dedman 1990). The remainder of the chapter is divided into the following sections. Firstly, we discuss the primary structures, and the sequence homologies which lead to the identification of the relationship between the annexins. We will also consider the emergence of data relating to crystal structure and gene regulation. Secondly, the biochemical properties of the annexins are reviewed, particularly with respect to calcium and phospholipid-binding, and the implications this has for the ability of all members of the family to inhibit phospholipase A2 and act as anticoagulants. Thirdly, the potential functional significance of phosphorylation by transforming and normal protein kinases is examined. Fourthly, we discuss the comparative patterns of tissue distribution and developmental regulation of the annexins and finally, we consider the diverse physiological roles which have been proposed for the individual annexin family proteins, and attempt to reconcile these with their known properties within a realistic conceptual framework.

Keywords

Tyrosine Phosphorylation Phospholipid Binding Annexin Family Potential Functional Significance Dependent Phospholipid Binding 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • Stephen E. Moss
  • Helena C. Edwards
  • Michael J. Crumpton

There are no affiliations available

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