Abstract
The thyroid cell, as many other cells, is subjected to controls through the cyclic AMP, the calcium-phosphatidylinositol and the growth factor receptors tyrosine protein kinases cascades. In the study of the proteins whose synthesis and postranslational covalent modifications are modulated by these cascades, we identified on two-dimensional gel electrophoresis a protein belonging to the calmodulin superfamily, which is phosphorylated in response to cyclic AMP, which binds calcium and which is synthesized in differentiating conditions: calcyphosine (Lefort et al. 1989). In this short review, we summarize recent data on the identification, cloning, sequencing, and properties of calcyphosine.
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© 1991 Springer-Verlag Berlin Heidelberg
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Lefort, A., Lecocq, R., Libert, F., Erneux, C., Lamy, F., Dumont, J. (1991). Cloning and Sequencing of a New Calmodulin Related Calcium-Binding Protein Controlled by Cyclic AMP Dependent Phosphorylation in the Thyroid: Calcyphosine. In: Heizmann, C.W. (eds) Novel Calcium-Binding Proteins. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76150-8_21
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DOI: https://doi.org/10.1007/978-3-642-76150-8_21
Publisher Name: Springer, Berlin, Heidelberg
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