Skip to main content

Distribution of the Calcium-Binding Proteins MRP-8 and MRP-14 in Normal and Pathological Conditions: Relation to the Cystic Fibrosis Antigen

  • Chapter
Novel Calcium-Binding Proteins

Abstract

Eukaryotic cells require calcium ions for optimal growth and functioning. The intracellular actions of calcium as a biological second messenger appear to be the result of its interaction with a set of calcium-binding proteins referred to as calcium modulated proteins. (Persechini et al. 1989).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Andersson KB, Sletten K, Berntzen HB, Dale I, Brandtzaeg P, Jellum E, Fagerhol MK (1988) The leukocyte L1 protein: identity with the cystic fibrosis antigen and the calcium-binding MRP-8 and MRP-14 macrophage components. Scand J Immunol 28:241–245.

    Article  PubMed  CAS  Google Scholar 

  • Berntzen HB, Munthe E, and MK Fagerhol (1988) The major leukocyte protein as an indicator of inflammatory joint disease. Scand J Immunol suppl 76:251–256.

    CAS  Google Scholar 

  • Brüggen J, Tarcsay L, Cerletti N, Odink K, Rutishauser M, Holländer G, Sorg C (1988) The molecular nature of the cystic fibrosis antigen. Nature 331:570.

    Article  PubMed  Google Scholar 

  • Brüggen J, Tarcsay L, Cerletti N, Wiesendanger W, Odink K, Rutishauser M, Holländer G, Schwartz M, Sorg C (1989) The plasma level of the calcium binding protein MRP-14 is elevated in patients suffering inflammatory disorders: Relation to the cystic fibrosis antigen. In: 1-st European Symposium on Calcium Binding Proteins in Normal and Transformed Cells. Presses Universitaires A.S.B.L., Bruxelles E 16 (Abstract).

    Google Scholar 

  • Brüggen J, Holländer G, Tarcsay L, Cerletti N, Odink K, Rutishauser M, Schwartz M, Sorg C (1990) The plasma level of the calcium-binding protein MRP-14 is elevated in inflammatory disorders. (submitted)

    Google Scholar 

  • Dorin JR, Novak M, Hill RE, Brock DJH, Secher DS, van Heyningen V (1987) A clue to the basic defect in cystic fibrosis from cloning the CF antigen. Nature 326:614–617.

    Article  PubMed  CAS  Google Scholar 

  • Freemont P, Hogg N, Edgeworth J (1989) Sequence identity. Nature 339:516.

    Article  PubMed  CAS  Google Scholar 

  • Hayward C, Glass S, Van Heyningen V, Brock DJH (1987) Serum concentrations of a granulocyte-derived calcium-binding protein in cystic fibrosis patients and heterozygotes. Clinica Chimica Acta 170:45–56.

    Article  CAS  Google Scholar 

  • Hogg N, Allen C, Edgeworth J (1989) Monoclonal antibody 5.5 reacts with p8,14, a molecule associated with some vascular endothelium. Eur J Immunol 19:1053–1061.

    Article  PubMed  CAS  Google Scholar 

  • Kato K, Haimoto H, Shimizu A, Tanaka J (1987) Enzyme immunoassay for measurement of the a subunit of S-100 protein in human biological fluids. Biomedical Research 8:119–125.

    CAS  Google Scholar 

  • Kerem BS, Rommens JM, Buchanan JA, Markiewicz D, Cox TK, Chakravarti A, Buchwald M, Tsui LC (1989) Identification of the cystic fibrosis gene: genetic analysis. Science 245:1073–1080.

    Article  PubMed  CAS  Google Scholar 

  • Lagasse E, Clerc R (1988) Cloning and expression of two human genes encoding calcium-binding proteins that are regulated during myeloid differentiation. Molec Cell Biology 8:2402–24110.

    CAS  Google Scholar 

  • Murao S, Collait FR and Hubermann E (1989) A protein containing the cystic fibrosis antigen is an inhibitor of protein kinases. J Biol Chem 164:8356–8360.

    Google Scholar 

  • Odink K, Cerletti N, Brüggen J, Clerc R, Tarcsay L, Zwadlo G, Gerhards G, Schlegel R, Sorg C. Two calcium-binding proteins in infiltrate macrophages of rheumatoid arthritis. Nature 330:80-82.

    Google Scholar 

  • Persechini A, Moncrief ND, Kretsinger RH (1989) The EF-hand family of calcium-modulated proteins. TINS 12:462–467.

    PubMed  CAS  Google Scholar 

  • Usui A, Kato K, Sasa H, Minaguchi K, Abe T, Murase M, Tanaka M, Takeuchi E (1990) S-100α0 protein in serum during myocardial infarction. Clin Chem 36/4:639–641.

    Google Scholar 

  • Watt KWK, Brightman I, Goetzl EJ (1983) Isolation of two polypeptides comprising the neutrophilimmobilizing factor of human leukocytes. Immunol 48:79–86.

    CAS  Google Scholar 

  • Wilfond BS, Fost N (1990) The cystic fibrosis gene: Medical and social implications for heterozygote detection. JAMA 263:2777–2782.

    CAS  Google Scholar 

  • Wilkinson MA, Busuttil A, Hayward C, Brock DJH, Dorin JR, van Heyningen V (1988) Expression pattern of two related cystic fibrosis-associated calcium-binding proteins in normal and abnormal tissues. J Cell Science 91:221–230.

    PubMed  CAS  Google Scholar 

  • Wright B, Zeidman I, Greig R, Poste G (1985) Inhibition of macrophage activation by calcium channel blockers and calmodulin antagonists. Cell Immunol 95:46–52.

    Article  PubMed  CAS  Google Scholar 

  • Zwadlo G, Brüggen J, Gerhards G, Schlegel R, Sorg C (1988) Two calcium-binding proteins associated with specific stages of myeloid cell differentiation are expressed by subsets of macrophages in inflammatory tissues. Clin Exp Immunol 72:510–515.

    PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1991 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Brüggen, J., Cerletti, N. (1991). Distribution of the Calcium-Binding Proteins MRP-8 and MRP-14 in Normal and Pathological Conditions: Relation to the Cystic Fibrosis Antigen. In: Heizmann, C.W. (eds) Novel Calcium-Binding Proteins. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76150-8_14

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-76150-8_14

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-76152-2

  • Online ISBN: 978-3-642-76150-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics