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Therapeutische Prinzipien bei Motilitätsstörungen des oberen Gastrointestinaltraktes mit besonderer Berücksichtigung der Refluxösophagitis und des Reizmagensyndroms (Non-ulcer Dyspepsie, NUD)

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Motilitätsstörungen im oberen Gastrointestinaltrakt
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Zusammenfassung

Die Achalasie ist gekennzeichnet durch 2 verschiedene Störungen am unteren Ösophagussphinkter bzw. im Bereich des tubulären Ösophagus mit unvollständiger bis völlig aufgehobener schluckreflektorischer Erschlaffung des unteren Ösophagussphinkters (UÖS) und erhöhtem Ruhedruck sowie mit Hypomotilität der tubulären Speiseröhre und weitgehend aufgehobener Peristaltik. Die Folge ist ein ausgeprägtes Dysphagiesyndrom mit Regurgitation bis hin zur Aspiration und chronischer Pneumonie.

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Literatur

  1. Wienbeck M, Berges W (1987) Motilitätsstörungen des Oesophagus. In: Koelz HR, Aerberhard P (Hrsg) Gastroenterologische Pathophysiologie. Springer, Berlin Heidelberg New York Tokyo, S 75–90

    Google Scholar 

  2. Koelz HR (1984) Refluxkrankheit der Speiseröhre — Konservative Therapie. In: Goebell H, Hotz J, Farthmann EH (Hrsg) Der chronisch Kranke in der Gastroenterologie. Springer, Berlin Heidelberg New York Tokyo, S 148–174

    Google Scholar 

  3. McCallum RW (1985) Recent advances in the medical therapy of gastroesophageal reflux. In: De Meester TR, Skinner DB (eds) Esophageal disorders. Pathophysiology and therapy. Raven, New York, pp 143–147

    Google Scholar 

  4. Harvey RF, Hadley N, Gill TR et al. (1987) Effects of sleeping with the bedhead raised and of ranitidine in patients with severe peptic oesophagitis. Lancet II:1200

    Article  Google Scholar 

  5. Meyer E, Berenzweig H, McCallum RW et al. (1979) Controlled trial of antacida versus placebo on relief of heartburn. Gastroenterology 76:1201

    Google Scholar 

  6. Furmann DR, Mensh G, McCallum RW et al. (1982) A double-blind trial comparing high dose liquid antacid to placebo and Cimetidine in improving symptoms and objective parameters in gastroesophageal reflux. Gastroenterology 82:1062

    Google Scholar 

  7. Graham DY, Patterson DJ (1982) Double-blind comparison of liquid antacid and placebo in reflux esophagitis. Gastroenterology 82:1072

    Google Scholar 

  8. Lepsien G, Sonnenberg A, Berges W et al. (1979) Die Behandlung der Reflux-oesophagitis mit Cimetidin. Dtsch Med Wochenschr 104:901

    Article  PubMed  CAS  Google Scholar 

  9. Wesdorp ICE, Bartelsman J, Pape K et al. (1978) Oral Cimetidine in reflux oesophagitis: a double-blind controlled trial. Gastroenterology 74:821

    PubMed  CAS  Google Scholar 

  10. Ferguson R, Dronfield MW, Atkinson M (1979) Cimetidine in treatment of reflux oesophagitis with peptic structure. Br Med J II:472

    Article  Google Scholar 

  11. McCallum RW, Eshelman F, Nardi R (1986) A double-blind multicenter trial compare the efficacy of ranitidine and placebo in the shortterm treatment of chronic gastroesophageal reflux disease. Gastroenterology 86:1179

    Google Scholar 

  12. Grove O, Bekker C, Jeppe-Hansen MG et al. (1985) Ranitidine and high-dose antacid in reflux oesophagitis. Scand J Gastroenterol 20:457

    Article  PubMed  CAS  Google Scholar 

  13. Wesdorp ICE, Dekker W, Klinkenberg-Knol EC (1983) Treatment of reflux oesophagitis with ranitidine. Gut 24:921

    Article  PubMed  CAS  Google Scholar 

  14. Fielding JF, Doyle GD (1984) Comparison between ranitidine and cimetidine in the treatment of reflux esophagitis. Ir Med J 77:356

    PubMed  CAS  Google Scholar 

  15. Kimming JM (1984) Cimetidine and ranitidine in the treatment of reflux esophagitis. Z Gastroenterol 22:373

    Google Scholar 

  16. Hetzel DJ, Dent J, Reed WD et al. (1988) Healing and relapse of severe peptic esophagitis after treatment with omeprazole. Gastroenterology 95:903

    PubMed  CAS  Google Scholar 

  17. Vantrappen G, Rutgeerts L, Schurmans P et al. (1988) Omeprazole (40 mg) is superior to ranitidine in short-term treatment of ulcerative reflux esophagitis. Dig Dis Sci 33:523

    Article  PubMed  CAS  Google Scholar 

  18. Lundell L, Westin IH, Sandmark S et al. (1989) Omeprazole or high dose ranitidine in the treatment of patients with reflux esophagitis not responding to standard doses of H2-receptor antagonists. Scand J Gastroenterol [Suppl 159] 24:73

    Google Scholar 

  19. Sandmark S, Carlsson R, Fausa O et al. (1988) Omeprazole or ranitidine in the treatment of reflux esophagitis. Scand J Gastroenterol 23:625

    Article  PubMed  CAS  Google Scholar 

  20. Carling L, Cronstedt J, Engqvist A et al. (1988) Sucralfate vs placebo in reflux esophagitis. Scand J Gastroenterol 23:1117

    Article  PubMed  CAS  Google Scholar 

  21. Weiss W, Brunner H, Büttner GR et al. (1983) Therapie der Refluxösophagitis mit Sucralfat. Dtsch Med Wochenschr 108:1706

    Article  PubMed  CAS  Google Scholar 

  22. Kilbinger H, Weihrauch TR (1984) Pharmakologie motilitätswirksamer Medikamente. In: Wienbeck M, Siewert JR (Hrsg) Therapie gastrointestinaler Motilitätsstörungen. Edition Medizin, Basel, S 1

    Google Scholar 

  23. Schulze-Delrieu K (1979) Metoclopramide. Gastroenterology 77:768

    PubMed  CAS  Google Scholar 

  24. Harrington RA, Hamilton CW, Brogden RN et al. (1983) Metoclopramide: An update revieu of its pharmacological properties and clinical use. Drugs 25:451–494

    Article  PubMed  CAS  Google Scholar 

  25. Gilbert RJ, Dodds WJ, Kahrilas PJ et al. (1987) Effect of cisapride, a new prokinetic agent, on esophageal motor function. Dig Dis Sci 32:1331–1336

    Article  PubMed  CAS  Google Scholar 

  26. Wienbeck M, Cruder-Wiesinger E, Berges W (1986) Coparative study of cisapride’s vs metoclopramide’s effect on esophageal motility. Digestion 34:141

    Google Scholar 

  27. Janisch HD (1990) Cisaprid vs Ranitidin bei Refluxoesophagitis. Z Gastroenterol [Suppl 1] 28:67–69

    PubMed  Google Scholar 

  28. Grill BB, Hillemeier AC, Semeraro LA (1985) Effect of domperidone therapy on symptoms and upper gastrointestinal motility in infants with gastrooesophageal reflux. J Pediatr 106:311–316

    Article  PubMed  CAS  Google Scholar 

  29. Bright-Assare P, El-Bassoussi M (1980) Cimetidine, metoclopramide or placebo in the treatment of symptomatic gastroesophageal reflux. J Clin Gastroenterol 2:149–156

    Article  Google Scholar 

  30. Guslandi M, Testoni PA, Passaretti S et al. (1983) Renitidine vs metoclopramide in the medical treatment of reflux esophagitis. Hepatogastroenterology 30:96

    PubMed  CAS  Google Scholar 

  31. Janisch HD, Hüttemann W, Bouzo MH (1988) Cisapride vs ranitidine in the treatment of reflux esophagitis. Hepatogastroenterology 35:125

    PubMed  CAS  Google Scholar 

  32. Lepoutre L, Vanderlinden I, Bollen G et al. (1987) Controlled study of cisapride in the treatment of grade II and III oesophagitis. Gastroenterology 92:1501

    Google Scholar 

  33. Galmiche JP, Brandstätter G, Evreux M et al. (1988) Combined therapy with cisapride and Cimetidine in severe reflux oesophagitis: a double blind controlled trial. Gut 29:675

    Article  PubMed  CAS  Google Scholar 

  34. Creutzfeldt W, Lamberts R, Stockmann F et al. (1989) Quantitative studies of endocrine cells in patients receiving long-term treatment with omeprazole. Scand J Gastroenterol [Suppl 166] 24:122–128

    Article  Google Scholar 

  35. Hotz J: Das Reizmagensyndrom. Perimed, Frankfurt am Main

    Google Scholar 

  36. Colin-Jones DG (1988) Management of dyspepsia: Report of a working party. Lancet I:576–579

    Google Scholar 

  37. Hotz J, Rösch W (Hrsg) (1987) Funktionsstörungen des Verdauungstraktes. Springer, Berlin Heidelberg New York Tokyo, S 5–16

    Google Scholar 

  38. Labò G, Bortolotti M, Vezzadini P et al. (1986) Gastroenterology 90:20–26

    PubMed  Google Scholar 

  39. Malagelada JR, Stanghellini V (1985) Manometric evaluation of functional upper gut symptoms. Gastroenterology 88:1223–1231

    PubMed  CAS  Google Scholar 

  40. Nyren O et al. (1986) Does an increased gastric acid production cause epigastric pain in non-ulcer dyspepsia? Scand J Gastroenterol [Suppl 120] 21:54

    Google Scholar 

  41. Petersen H et al. (1987) The response to Cimetidine and gastric acid secretion in non-ulcer dyspepsia. Hepatogastroenterology 34:41

    Google Scholar 

  42. Graham DY et al. (1987) Sensitivity of the esophageal mucosa to pH in gastroesophageal reflux. Gastroenterology 92, 5/2:1312

    Google Scholar 

  43. Nyren O (1988) Non-ulcer dyspepsia: A candidate of motility disorders. Motility, Issue 3:4–10

    Google Scholar 

  44. Brooks FP (1978) The pathophysiology of common gastrointestinal symptoms. Oxford Univ Press, New York

    Google Scholar 

  45. Texter EC (1987) Ulcer pain mechanisms. Scand J Gastroenterol [Suppl 134] 22:1–20

    Article  Google Scholar 

  46. Shallcross TM, Rathbone BJ, Heatley RV (1989) Campylobacter pylori and non-ulcer dyspepsia. In: Rathbone BJ, Heatley RV (eds) Campylobacter pylori and gastroduodenal disease. Blackwell, Oxford, pp 155–166

    Google Scholar 

  47. Rösch W (1990) Abdominelle Beschwerden — funktionell oder organisch? programmed 3:21–27

    Google Scholar 

  48. Berkowitz DM, Metzger WH, Sturdevant RAL (1976) Oral metoclopramide in diabetic gastroparesis and in chronic gastric retention after gastric surgery. Gastroenterology 70:863

    Google Scholar 

  49. Davidson ED, Hersh T, Ilaun C, Brooks WS (1977) Use of metoclopramide in patients with delayed gastric emptying following gastric surgery. Am Surg 411:40–44

    Google Scholar 

  50. Perkel MS, Hersh T, Moore C, Davidson EO (1980) Metoclopramide therapy in fifty-five patients with delayed gastric emptying. Am J Gastroenterol 74:231–236

    PubMed  CAS  Google Scholar 

  51. Rhodes JB, Robinson RG, McBride N (1979) Sudden onset of slow gastric emptying of food. Gastroenterology 77:569–571

    PubMed  CAS  Google Scholar 

  52. Saleh JW, Lebwohl P (1980) Metoclopramide-induced gastric emptying in patients with anorexia nervosa. Am J Gastroenterol 742:127–132

    Google Scholar 

  53. Kurtz W (1985) Die Therapie des dyspeptischen Symptomenkomplexes. Therapiewoche 35:5413–5420

    Google Scholar 

  54. Rösch W (1990) Abdominelle Beschwerden — funktionell oder organisch? programmed 3:21–27

    Google Scholar 

  55. Johnson AG, Lux G (1988) Progress in the treatment of gastrointestinal motility disorders: The roll of cisapride. Exerpta Medica, Amsterdam Hongkong Manila Pinceton Sidney Tokyo

    Google Scholar 

  56. De Nutte N, Van Ganse W, Witterhulghe M et al. (1989) Relief of epigastric pain in nonulcer dyspepsia: Controlled trial of the promotility drug cisapride. Clin Ther 11(1)

    Google Scholar 

  57. Hannon R (1987) Efficacy of cisapride in patients with nonulcer dyspepsia. Curr Ther Res 42(5)

    Google Scholar 

  58. Francois I, De Nutte N (1987) Nonulcer dyspepsia: Effect of the gastrointestinal pro-kinetic drug cisapride. Curr Ther Res 41(6)

    Google Scholar 

  59. Deruyttere M et al. (1987) Therapy of chronic functional dyspepsia: multicentre crossover study of cisapride and placebo. Progr Med [Suppl 1] 45:61–68

    Google Scholar 

  60. Rösch W (1987) Cisapride in non-ulcer dyspepsia. Scand J Gastroenterol 22:161–164

    Article  PubMed  Google Scholar 

  61. Weberg R, Berstad A (1987) Low-dose antacids and pirenzepine in the treatment of patients with non-ulcer dyspepsia and erosive prepyloric changes. Scand J Gastroenterol 23:237–242

    Article  Google Scholar 

  62. Panijel M (1985) Die Behandlung der nicht-ulcerösen Dyspepsie. ZFA 61:952–955

    Google Scholar 

  63. Casiraghi A, Ferrara A, Lesinigo et al. (1986) Cimetidine vs. antacids in non-ulcer dyspepsia. Curr Ther Res 39:388–397

    Google Scholar 

  64. Gotthard R, Bodemar G, Brodin U et al. (1988) Treatment with Cimetidine, antacid or placebo in patients with dyspepsia of unknown origin. Scand J Gastroenterol 23:7–18

    Article  PubMed  CAS  Google Scholar 

  65. Talley N, McNeil D, Hayden A et al. (1986) Randomized, double-blind, placebo-controlled cross-over trial of Cimetidine and pirenzepine in non-ulcer dyspepsia. Gastroenterology 91:149–156

    PubMed  CAS  Google Scholar 

  66. Fedeli G, Anti M, Rapaccini G et al. (1983) Pirenzepine vs. Cimetidine in non-ulcer associated gastritis and duodenitis. Clin Trials J 20:104–114

    Google Scholar 

  67. Petersen H, Fjøsne U, Johannessen T et al. (1989) Clinical significance of upper abdominal symptoms. Scand J Gastroenterol [Suppl 109] 20:19–22

    Article  Google Scholar 

  68. Petersen H, Løge J, Johannessen T (1987) Therapeutic response as a diagnostic tool. Scand J Gastroenterol [Suppl 128] 22:108–112

    Article  Google Scholar 

  69. Johannessen T, Fjøsne U, Kleveland N (1988) Cimetidine responders in non-ulcer dyspepsia. Scand J Gastroenterol 23:327–336

    Article  PubMed  CAS  Google Scholar 

  70. Delattre M, Malesky M, Primzic A (1985) Symptomatic treatment of non-ulcer dyspepsia with Cimetidine. Curr Ther Res 37:980–991

    Google Scholar 

  71. Saunders JHB, Oliver RJ, Higson DL (1986) Dyspepsia: Incidence of non-ulcer disease in a controlled trial of ranitidine in general practice. Br Med J 292:665–668

    Article  CAS  Google Scholar 

  72. Nyren O, Adami H-O, Bates S et al. (1986) Absence of therapeutic benefit from antacids of Cimetidine in non-ulcer dyspepsia. N Engl J Med 314:339

    Article  PubMed  CAS  Google Scholar 

  73. Kelbaeck H, Linde J, Eriksen J et al. (1985) Controlled clinical trial of treatment with Cimetidine in non-ulcer dyspepsia. Acta Med Scand 217:281–287

    Article  Google Scholar 

  74. Lance P, Filipe MI, Schiller KFR et al. (1981) Cimetidine for non-ulcer dyspepsia. Gastroenterology 80, 5/2:1203

    Google Scholar 

  75. McNulty CAM, Gearty JC, Crump B et al. (1986) Campylobacter pyloridis and associated gastritis: investigator blind, placebo controlled trial of bismuth salicylate and erythromycin ethylsuccinate. Br Med J 293:645–649

    Article  CAS  Google Scholar 

  76. Lambert JR, Borromeo M, Korman MG et al. (1987) Role of Campylobacter pyloridis in non-ulcer dyspepsia — arandomized controlled study. Gastroenterology 92, 5/2:1488

    Google Scholar 

  77. Borody T, Hennessy W, Daskalopoulos G et al. (1987) Double blind trial of DeNol in nonulcer dyspepsia associated with Campylobacter pyloridis gastritis. Gastroenterology 92, 5/2:1324

    Google Scholar 

  78. Rokkas T, Pursey C, Uzoechina E et al. (1988) Non-ulcer dyspepsia short term DeNol therapy: a placebo controlled trial with particular references to the role of Campylobacter pylori. Gut 29:1386–1391

    Article  PubMed  CAS  Google Scholar 

  79. Loffeld RJLF, Potters HVJP, Stobberingh E et al. (1989) Campylobacter associated gastritis in patients with non-ulcer dyspepsia: a double-blind placebo controlled trial with colloidal bismuth subcitrate. Gut 30:1206–1212

    Article  PubMed  CAS  Google Scholar 

  80. Glupczyski Y, Burete A, Labbe M et al. (1988) Campylobacter pyloriassociated gastritis: a double blind placebo controlled trial with amoxycillin. Am J Gastroenterol 83:365–372

    Google Scholar 

  81. Vogelberg KH (1988) Magenentleerungsstörungen bei diabetischer Gastroparese. Dtsch Med Wochenschr 113:988–991

    Article  PubMed  CAS  Google Scholar 

  82. Lux G (1989) Gastrointestinale Motilitätsstörungen-Diabetes mellitus. Leber Magen Darm 2:84–93

    Google Scholar 

  83. Haslbeck M (1990) Behandlung der diabetischen Gastroparese. Z Gastroenterol [Suppl 1] 28:39–42

    PubMed  Google Scholar 

  84. Miliar JW, Heading RC, Campell IW et al. (1980) Metoclopramide in diabetic gastric atony. Scott Med J 25:176

    Google Scholar 

  85. Snape WJ, Battle WM, Schwartz SS et al. (1982) Metoclopramide to treat gastroparesis due to diabetes mellitus. A double-blind, controlled trial. Ann Intern Med 96:444–446

    PubMed  Google Scholar 

  86. Corinaldesi R, Raiti C, Stanghenelli V et al. (1987) Comperative effects of oral cisapride and metoclopramide on gastric emptying of solids and symptoms in patients with functional dyspepsia and gastroparesis. Curr Ther Res 42:428–435

    Google Scholar 

  87. Reyntjens A, Verlinden M, Schuermans V (1990) Cisapride in the treatment of chronic intestinal pseudo-obstruction. Z Gastroenterol [Suppl 1] 28:79–84

    PubMed  Google Scholar 

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Hotz, J. (1990). Therapeutische Prinzipien bei Motilitätsstörungen des oberen Gastrointestinaltraktes mit besonderer Berücksichtigung der Refluxösophagitis und des Reizmagensyndroms (Non-ulcer Dyspepsie, NUD). In: Hotz, J. (eds) Motilitätsstörungen im oberen Gastrointestinaltrakt. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76148-5_3

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