Abstract
A chemical meningitis may complicate intraventricular or intrathecal chemotherapy, and has been best described in patients receiving methotrexate (MTX) [1]. It is characterised by headaches, vomiting, nuchal rigidity, Kernig’s sign, photophobia, delirium, and obtundation. A more or less complete and severe clinical manifestation of this chemical arachnoiditis occurs 2 to 4 hours after intrathecal injection of MTX. Meningism is rarely seen after a first administration of MTX, but incidence increases with the number of intrathecal injections and is dose related [2].
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© 1990 Springer-Verlag Berlin Heidelberg
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Hildebrand, J. (1990). Acute Meningeal Reaction. In: Hildebrand, J. (eds) Neurological Adverse Reactions to Anticancer Drugs. ESO Monographs. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76142-3_8
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DOI: https://doi.org/10.1007/978-3-642-76142-3_8
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