Zusammenfassung
Veränderungen der zentralnervösen serotoninergen Aktivität, reflektiert sowohl durch Konzentrationsverschiebungen des Transmitters wie durch veränderte Rezeptorbindungsaffinitäten, werden seit mehreren Jahren vermehrt in Zusammenhang mit der Ätiologie affektiver Erkrankungen gebracht (zur Übersicht: Holsboer 1990). Basierend auf Beobachtungen von Verhalten, das in Zusammenhang mit bestimmten Affektstörungen zu bringen ist und welches unter serotoninerger Kontrolle zu stehen scheint, wie Aggressivität, verminderte Impulskontrolle, psychomotorische Aktivierung, Angst und Suchtabhängigkeitsentwicklung, und auf Grund neurochemischer und neuropathologischer Befunde, wurde analog der Noradrenalinhypothese eine Serotoninhypothese affektiver Erkrankungen formuliert. Von besonderem Interesse scheint hierbei zu sein, daß es in den letzten Jahren sowohl insbesondere durch Anwendung selektiver Rezeptorliganden als auch durch molekularbiologische Methoden gelungen ist, die Serotoninrezeptoren näher zu charakterisieren und ihre Funktionszusammenhänge weiter aufzuklären. Es ist daher Ziel dieser Übersicht, die serotoninerge Neurotransmission sowohl auf der Basis neuerer Befunde bezüglich ihrer Pharmakologie als auch mit ihren Interaktionen mit anderen Transmitter- und endokrinen Regulationssystemen zu beschreiben, und auf dieser Grundlage die Befunde bei affektiven Erkrankungen zu diskutieren.
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Wiedemann, K., Holsboer, F. (1991). Serotoninerge ZNS-Regulation bei affektiven Erkrankungen — Ausgewählte Beispiele aus der Grundlagenforschung. In: Laakmann, G. (eds) Selektive Re-uptake-Hemmung und ihre Bedeutung für die Depression. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76137-9_5
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