Multiple Advantages Before and After Radical Prostatectomy with Combined Endocrine Therapy
Cancer of the prostate has become, with lung cancer, the most common cancer in men. It is estimated that 98000 new cases of prostate cancer would be diagnosed in the United States in 1988 . In addition, cancer of the prostate is the second leading cause of cancer death in men. Prostatic carcinoma is found in 6%–10% of prostatectomy specimens after resection for benign prostatic hyperplasia by routine sectioning. However, the incidence rate increases to 25%–40% if step sections are used [2, 3]. At autopsy, a similar incidence is found, namely 15%–17% by random sections and 46%–57% by step sections . The lifetime probability of diagnosis of this disease is 5.2% and 9.6% in White and Black men, respectively . In addition to the high frequency of this disease, diagnosed in one out of 20 men during their lifetime, more than 50% of the patients have reached the stage of metastases (D1 or D2) when the cancer is first discovered. At this late stage, endocrine therapy is the standard and only efficient treatment  (for review, see ).
KeywordsPlacebo Estrogen Adenocarcinoma Phenyl Testosterone
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