Antivirals in Treatment of Experimental Bacterial and Fungal Infections
Six synthetic (derivatives of 1,3,5-naphthalentrisulfonic acid, of 1,3,4-oxadiazine, and of tetrahydro-2/1H/-pyrimidinone) and natural (bipolymeric fungal polysaccharide, water-soluble fraction of bee propolis, and plant saponin complex) substances were tested in vivo for antibacterial and antifungal protection. All compounds possessed in vivo and/or in vitro antiviral activities paralelly with the ab-sence of in vitro antibacterial and antifungal effects. Administered in different doses, routes and preinoculation intervals the substances provided protection in experimental infections induced by bacteria (Kl. pneumoniae, S. aureus) and by fungi (C. albicans) in intact or in immunocompromized host. The stimulation of the nonspecific resistance was demonstrated by an increase of the survival rate and the mean survival time. The strong antiinfectious protection is suggested to be mediated by their immunomodulatory capacity.
KeywordsExperimental Infection Direct Antiviral Action Mean Survival Time Infectious Bovine Rhinotracheitis Nonspecific Resistance
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