Antivirals in Treatment of Experimental Bacterial and Fungal Infections
Six synthetic (derivatives of 1,3,5-naphthalentrisulfonic acid, of 1,3,4-oxadiazine, and of tetrahydro-2/1H/-pyrimidinone) and natural (bipolymeric fungal polysaccharide, water-soluble fraction of bee propolis, and plant saponin complex) substances were tested in vivo for antibacterial and antifungal protection. All compounds possessed in vivo and/or in vitro antiviral activities paralelly with the ab-sence of in vitro antibacterial and antifungal effects. Administered in different doses, routes and preinoculation intervals the substances provided protection in experimental infections induced by bacteria (Kl. pneumoniae, S. aureus) and by fungi (C. albicans) in intact or in immunocompromized host. The stimulation of the nonspecific resistance was demonstrated by an increase of the survival rate and the mean survival time. The strong antiinfectious protection is suggested to be mediated by their immunomodulatory capacity.
KeywordsPneumonia Polysaccharide Phenylen Resi Cyclophosphamide
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- Azuma I, Jolles G (eds) (1987) Immunostimulants. Now and tomorrow. Japan Scientific Societies Press, Tokyo/Springer Verlag, Berlin Heidelberg New YorkGoogle Scholar
- Dimov VB (1989) Nonspecific immunostimulation. In: Toshkov AS, Dimov VB, Denchev VD, Vassilev TL Immunomodulators in infectious diseases. Medicina i fizkultura, Sofia, p. 248Google Scholar
- Fenichel RL, Chirigos MA (1984) Immune modulating agents and their mechanisms. Immunology series, vol 25, Marcel Dekker, New York, p. 678Google Scholar
- Galabov A, Velichkova E, Karparov A, Sizdhakova D, Danchev D, Chakova N (1984) Antiviral activity of tetrahydro-2/1H/-pyrimidinones and related compounds. Arzneim Forsch/Drug Res 34: 9–14Google Scholar
- Manolova N, Maximova V, Gegova G, Serkedjieva Y, Uzunov S, Marekov N, Bankova V (1985) On the antiinfluenza action of fraction from propolis. C R Acad Bulg Sci 38: 735–737Google Scholar