Abstract
Six synthetic (derivatives of 1,3,5-naphthalentrisulfonic acid, of 1,3,4-oxadiazine, and of tetrahydro-2/1H/-pyrimidinone) and natural (bipolymeric fungal polysaccharide, water-soluble fraction of bee propolis, and plant saponin complex) substances were tested in vivo for antibacterial and antifungal protection. All compounds possessed in vivo and/or in vitro antiviral activities paralelly with the ab-sence of in vitro antibacterial and antifungal effects. Administered in different doses, routes and preinoculation intervals the substances provided protection in experimental infections induced by bacteria (Kl. pneumoniae, S. aureus) and by fungi (C. albicans) in intact or in immunocompromized host. The stimulation of the nonspecific resistance was demonstrated by an increase of the survival rate and the mean survival time. The strong antiinfectious protection is suggested to be mediated by their immunomodulatory capacity.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Azuma I, Jolles G (eds) (1987) Immunostimulants. Now and tomorrow. Japan Scientific Societies Press, Tokyo/Springer Verlag, Berlin Heidelberg New York
Dimov VB (1989) Nonspecific immunostimulation. In: Toshkov AS, Dimov VB, Denchev VD, Vassilev TL Immunomodulators in infectious diseases. Medicina i fizkultura, Sofia, p. 248
Fenichel RL, Chirigos MA (1984) Immune modulating agents and their mechanisms. Immunology series, vol 25, Marcel Dekker, New York, p. 678
Gagov G, Toshkov A, Mihailov Y, Georgiev D, Tsvetkov P, Petkova K, Moukova L, Georgiev G, Drianovska-Noninska L (1984) Antiviral effect of the compounds of 1,3,4-oxadiazine on the reproduction of virus IBR. Acta Microbiol Bulg 14: 129–132
Galabov A, Velichkova E, Karparov A, Sizdhakova D, Danchev D, Chakova N (1984) Antiviral activity of tetrahydro-2/1H/-pyrimidinones and related compounds. Arzneim Forsch/Drug Res 34: 9–14
Manolova N, Maximova V, Gegova G, Serkedjieva Y, Uzunov S, Marekov N, Bankova V (1985) On the antiinfluenza action of fraction from propolis. C R Acad Bulg Sci 38: 735–737
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1990 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Dimov, V.B., Ivanovska, N.D. (1990). Antivirals in Treatment of Experimental Bacterial and Fungal Infections. In: Masihi, K.N., Lange, W. (eds) Immunotherapeutic Prospects of Infectious Diseases. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76120-1_8
Download citation
DOI: https://doi.org/10.1007/978-3-642-76120-1_8
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-76122-5
Online ISBN: 978-3-642-76120-1
eBook Packages: Springer Book Archive