ISCOMS : Application in Infectious Diseases

  • B. Morein
Conference paper


The common problem for defined purified antigens or antigen determinants has been to make them immunogenic regardless of whether they are produced conventionally or produced as cloned gene technology products or chemically synthesized. In order to make antigen immunogenic the first problem is to get the antigen into a microscopic or submicroscopic particle where the antigen is presented in several copies, i.e. as a multimer. For some antigens it also seems necessary to enhance the immunogenicity with an adjuvant. The iscom — immunostimulating complex — was created to fulfil these criteria by assembling antigens in a multimeric form on a matrix with built-in adjuvant to form a particle. The components are held together by hydrophobic interactions (Morein et al., 1984 and for references see Höglund et al., 1989).


Influenza Virus Rabies Virus Measle Virus Canine Distemper Virus Intranasal Application 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • B. Morein
    • 1
  1. 1.Department of Virology, National Veterinary Institute and SwedishUniversity of Agricultural Sciences, Biomedical CentreUppsalaSweden

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