Summary
Synthetically prepared derivatives of the cell wall of Gram-negative bacteria were tested for their immunomodulatory properties in mice. Besides being able to activate splenic B cells polyclonally, as demonstrated by measuring the incorporation of [3H]thymidine into DNA, they could be shown to act as immunoadjuvants increasing the anti-SRBC and the anti-DNP-BSA immune responses, to enhance the vaccine effect of Salmonella vaccines, and to induce tumor cytotoxicity in bone marrow-derived cultured macrophages. The results show that such derivatives of the bacterial cell wall constitute potent immunomodulators in vitro and in vivo.
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© 1990 Springer-Verlag Berlin Heidelberg
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Bessler, W.G. et al. (1990). Bacterial Surface Components as Immunomodulators. In: Masihi, K.N., Lange, W. (eds) Immunotherapeutic Prospects of Infectious Diseases. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76120-1_4
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DOI: https://doi.org/10.1007/978-3-642-76120-1_4
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