Summary
Enteric coated lectin from Triticum vulgare (WGA) was used for oral administration in men. This encapsulated WGA stimulates human T-lymphocytes in vivo, increases the γ-interferon level (IFN) in serum and leads also to a strong enhancement of the ingestion rate in granulocytes without significant changes in the lysosomal enzyme production. The oral administration of enteric coated WGA represents a new way for immunostimulation in humans and could be a chance to increase the effectiveness of viral and bacterial vaccines.
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References
Aizpurua HJ, Russel-Jones GJ (1988) Oral vaccination, identification of classes of proteins that provoke an immune response upon oral feeding. J Exp Med 167: 440–451
Brady PG, Vannier AM, Banwell JG (1978) Identification of the dietary lectin, wheat germ agglutinin, in human intestinal contents. Gastroenterology 75: 236–239
Christiansen NP, Skubitz KM (1988) Identification of the major lectin-binding surface proteins of human neutrophils and alveolar macrophages. Blood 71: 1624–1632
Freed DLJ, Buckley CH (1978) Mucotractive effect of lectin. The Lancet 585–586
Gallily R, Stain I, Zaady O (1986) Dual effect of lectins on macrophages: Potentation of bacterial uptake and suppression of bactericidal activity. Immunology Letters 13: 151–158
Luther P, Noack K, Reutgen H (1988) Lectins and their role in a new polyvalent bacterial vaccine against ARI. Zbl Bakt Hyg A 270: 16–21
Mazzuca M, Lhermitte M, Lafitte JJ, Roussel P (1982) Use of lectins for detection of glycoconjugates in the glandular cells of the human bronchial mucosa. J Histochem Cytochem 30: 956–966
Ofek I, Sharon N (1988) Lectinophagocytosis: a molecular mechanism of recognition between cell surface sugars and lectins in the phagocytosis of bacteria. Infection and Itmnunity 56: 539–547
Reutgen H, Sehrt I, Stoffer B, Renner H, Hennig R (1988) Zur immunmodulatorischen Wirkung ausgewählter Lektine bei Granulozyten und Alveolarmakrophagen. Allerg Imnunol 34: 285–286
Satoh M, Yamazaki M (1987) Glycoprotein receptors to wheat germ agglutinin on the surface of murine macrophages. J Pharmacobio-Dyn 10: 608–615
Schubert K, Noack K, Luther P (1989) Interferoninduzierende Effekte von Lektinen in vitro und nach oraler Applikation. Z Erkrank Atm Org 173: 166–169
Sehrt I, Reutgen H, Luther P, Renner H (1990) Effect of orally administered lectin. Lysosomal enzyme activity in alveolar macrophages. In: Lectins. Biology, Biochemistry, Clinical Biochemistry, Vol. 9 (in press)
Sharon N (1986) Bacterial lectins. In: Liemer E, Sharon N, Goldstein IJ (eds). The Lectins: 494–522, Academic Press, London
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© 1990 Springer-Verlag Berlin Heidelberg
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Luther, P. et al. (1990). Orally Administered Lectin Stimulates Defence Mechanisms in Humans. In: Masihi, K.N., Lange, W. (eds) Immunotherapeutic Prospects of Infectious Diseases. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76120-1_30
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DOI: https://doi.org/10.1007/978-3-642-76120-1_30
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-76122-5
Online ISBN: 978-3-642-76120-1
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