Infiltration of Host Cells in Local Tumor Sites Triggered by the Administration of Anti-Tumor Polysaccharide, Lentinan
Lentinan (LNT), a ß-(1→3)-D-glucan type polysaccharide with ß-(1→6)-branched chain, exerts antitumor activities for animal models and clinical use (Chihara et al. 1970, Zakany et al. 1980, Suga et al. 1984, Chihara et al. 1987, Taguchi et al. 1985). A number of previous studies has revealed that the antitumor action of lentinan is exerted through the activation of host immune systems, particularly activation of T-cell macrophage synergism system(Maeda and Chihara 1973, Dennert and Tacker 1973, Hamuro and Chihara 1985). In the present study, we report that tumor growth inhibitory activity of LNT varies depending on the difference of tumor-host systems. The difference of sensitivity for LNT among various tumor strains was investigated from a view point of both histological changes of tumors and biological activities of tumor infiltrated cells which were induced with LNT treatment.
KeywordsFiltration Polysaccharide Fractionation Sarcoma Autochthonous
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