Abstract
Azidothymidine (AZT) is the only drug currently approved for treating HIV infections. AZT treatment results in decreased mortality and frequency of opportunistic infections but is associated with bone marrow depression or failure (Pizzo 1988). The termination of AZT treatment results in increased levels of viral core protein p24 and decreased numbers of CD4+ cells (Jackson 1988).
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Galleli A, Lefrancier P, Chedid, L. (1984) Colony stimulating activity induced by synthetic muramyl dipeptide: variation with chemical structure and association with anti-infectious activity. Infect Immun 46: 495–500
Galleli A, Charlotte B, Phillips NC, Chedid L (1989) Induction of colony-stimulating activity in mice by injection of liposomes containing lipophilic muramyl dipeptide derivatives. Cancer Res 49: 810–815
Jackson GG, Paul DA, Falk LA, Rubenis M, Despotes JC, Mack DM, Knigge M, Emeson EE (1988) Human immunodeficiency virus (HIV antigenemia (p24) in the acquired immunodeficiency syndrome (AIDS) and the effect of treatment with zidovudine ( AZT ). Ann Int Med 108: 175–180
Lieschke GJ, Maher D, Cebon J, O’Connor M, Green M, Sheridan W, Boyd A, Railings M, Bonnen E, Metcalf D, Burgess AW, McGrath K, Fox RM, Morstyn G (1989) Effects of bacterially synthesized recombinant human granulocyte-macrophage colony-stimulating factor in patients with advanced malignancy. Ann Intern Med 110: 357–364
Metcalf D, Begley CD, Johnson GR, Nicola NA, vadas MA, Lopez AF, Williamson DJ, Wong GG, Clark SC, Wang EA (1986) Biologic properties in vitro of a recombinant human granulocyte-macrophage colony-stimulating factor. Blood 67: 37–45
Nemunaitis J, Singer JW, Buchner CD, Hill R, Storb R, Thomas ED, Appelbaum FR (1988) Use of recombinnat human granulocyte -macrophage colony-stimulating factor in autologous marrow transplantation for lymphoid malignancies. Blood 72: 834–836
Oppenheim JJ, Togawa A, Chedid L, Mizel S (1980) Components of mycobacteria and muramyl dipeptide with adjuvant activity induce lymphocyte-activating factor. Cell Immunol 50: 71–81
Phillips, NC,. Moras ML, Chedid, L, Lefrancier P, Bernard J-M (1985) Activation of alveolar macrophages and eradication of experimental metastases by freeze-dried liposomes containing a new lipophilic muramyl dipeptide derivative. Cancer Res 45: 128–134
Phillips NC (1988) Liposomal muramyl dipeptide is more potent than free muramyl dipeptide in inducing I1–1 secretion from macrophages. In: Powanda MC, Oppenheim JJ, Kluger MJ, Dinarello CA (eds) Monokines and Other Non-Lymphocytic Cytokines. Alan R. Liss, Inc., New York p 141
Pizzo PA, Eddy J, Falloon J, Balis FM, Murphy RF, Moss H, Wolters P, Brouwers P, Jarosinski P, Rubin M, Broder S, Yarchoan R, Brunetti A, Maha M, Nusinoff-Lehrman S, Poplack DG (1988) Effect of continuous intravenous infusion of zidovudine (AZT) in children with symptomatic HIV infection. New Engl J Med 319: 889–896
Pojda Z, Molineux G, Dexter TM. (1989) Effects of long-term in vivo treatment of mice with purified murine recombinant GM-CSF. Exp Hematol 17: 1100–1106
Schaafsma MR, Falkenberg JHF, Duinerken N, van Damme J, Altrock BW, Willemze R, Fibbe WE (1989) interleukin-1 synergizes with granulocyte-macrophage stimulating factor on granulocyte colony formation by intermediate production of granulocyte colony -stimulating factor. Blood 74: 2398–2404
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© 1990 Springer-Verlag Berlin Heidelberg
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Phillips, N.C., Tsoukas, C., Chedid, L. (1990). Abrogation of Azidothymidine-Induced Bone Marrow Toxicity by Free and Liposomal Muramyl Dipeptide. In: Masihi, K.N., Lange, W. (eds) Immunotherapeutic Prospects of Infectious Diseases. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76120-1_16
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DOI: https://doi.org/10.1007/978-3-642-76120-1_16
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