Abstract
Common bacterial infections are increasingly being diagnosed in HIV-infected individuals. Cells of the monocyte-macrophage lineage kill invading bacterial pathogens and subsequently release immunoadjuvant components from the degraded cell walls. Since certain bacterial components possess immunomodulatory properties, an investigation of their effects on HIV-infected monocytes is of interest. Synthetic muramyl dipeptide, mycobacterial trehalose dimycolate, and a detoxified endotoxin preparation, monophosphoryl lipid A, were tested. Activity of antiretroviral agents, such as AZT, 2′,3′-ddA and gamma-interferon, were observed for comparison in the same U937-infection model. Cell counts and viability were determined on day 7 and culture supemates were collected. Antiviral activity was assayed by determining the amounts of HIV p24 antigen in infected cells. Antiretrovirals strongly inhibited p24 antigen production. Immunomodulators MDP, TDM and MPL could also reduce the replication of HIV in promonocytic cells at an early stage of infection.
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© 1990 Springer-Verlag Berlin Heidelberg
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Rohde-Schulz, B., Masihi, K.N., Lange, W. (1990). Reduced Replication of Human Immunodeficiency Virus in Promonocytic Cells by Bacterial Immunomodulators and Anti-Retroviral Drugs at an Early Stage of HIV-Infection. In: Masihi, K.N., Lange, W. (eds) Immunotherapeutic Prospects of Infectious Diseases. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76120-1_15
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DOI: https://doi.org/10.1007/978-3-642-76120-1_15
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