Abstract
The immunologic properties of extracts of human buffy coat leukocytes were initially described by Lawrence in the 1950’s (Lawrence 1955). These investigators were able to show that administration of dialysates prepared from the leukocytes of individuals having a strong sensitivity to a given antigen could affect the ability of the recipient to mount a delayed type hypersensitivity reaction to that antigen. The nature of this transfer phenomenon and its mediators was not clear. A series of reports appeared over the next several years which described the clinical benefits of administering leukocyte dialysates to patients with conditions in which a disordered immune system contributed to the disease process. A striking example of the effect of such treatment was seen in patients with chronic mucocutaneous candidiasis (Fudenberg, et al. 1972).
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Centers for Disease Control (1987) Revisions of the CDC Surveillance Case Definition for Acquired Immunodeficiency Syndrome. MMWR 36: 1S–15S
Corbiel L, Ceuppens JL, Van den Berghe G, Claeys H, Casteels-Van Daele M (1984) Immunological Observations Before and After Successful Treatment of Chronic Mucocutaneous Candidiasis with Ketoconazole and Transfer Fractor. European J Pediatrics 143: 45–48
Fudenberg HH, Spitler LE, Levin AS (1972) Treatment of Immunodeficiency. Amer J Pathol 69: 529–536
Gottlieb AA, Farmer JL, Benes E, Montgomery A, Del Signore C, Smith R, Bertucci D, and Sinha S (1987) Augmentation of Antigen-Induced Interleukin-2 Receptor Expression and Gamma-Interferon Production by IMREG-1, a Leukocyte Derived Immunomodulator. In: Pruzanski W, Seligmann M (eds) Clinical Immunology. Elsevier, New York Amsterdam London, p 357
Gottlieb AA, Farmer JL, Matzura C, Hester RB, and Rosenberg JS (1984) Modulation of Human T Cell Production of Migration Inhibitory Lymphokines by Cytokines Derived from Human Leukocyte Dialyzates. J Immunol 132: 256–260
Kirkpatrick, CH (1984) Host Factors in Defense Against Fungal Infection. Amer J Med 77: 1–12
Kirkpatrick CH, Greenberg LE (1979) Treatment of Chronic Mucocutaneous Candidiasis with Transfer Factor. In: Kahn A, Kirkpatrick CH, Hill NO (eds) Immune Regulators in Transfer Factor. Academic Press, New York, p547
Lawrence HS (1955) The Transfer in Humans of Delayed Skin Sensitivity to Streptococcal M Substances and to Tuberculin with Disrupted Leukocytes. J Clin Invest 34: 219–230
Leggot PJ, Robertson PB, Greenspan P, Wara DW, Greenspan JS, (1987) Oral Manifestation of Primary and Acquired Immunodeficiency Diseases in Children. Pediatric Dentistry 9: 98–104
Sinha SK, Sizemore RC, Gottlieb AA (1988) Immunomodulatory Components Present in IMREG-1, an Experimental Immunosupportive Biologic. Biotechnology 6: 810–815
Zangerle R, Fritsch P (1989) Candidiasis and the Immunodeficient Host: an update. Current Problems in Dermatology 18: 185–152.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1990 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Gottlieb, A.A., Gottlieb, M.S. (1990). Experience with IMREG-1, a Leukocyte Derived Immunomodulator on Candidiasis and Progression of Disease in Patients with AIDS-Related Complex. In: Masihi, K.N., Lange, W. (eds) Immunotherapeutic Prospects of Infectious Diseases. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76120-1_14
Download citation
DOI: https://doi.org/10.1007/978-3-642-76120-1_14
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-76122-5
Online ISBN: 978-3-642-76120-1
eBook Packages: Springer Book Archive