Biological Actions of Polysaccharides and Those Derivatives Against Cancer and AIDS

  • Y. Kaneko
  • Y. Yamamoto
  • T. Uryu


The first finding of biological activities of polysaccharides against cancer shall be seen in the article which reported an antitumor activity of yeast extracts (De Backer, 1987), and the activity was also observed in experimental model using transplantable and spontaneous malignant tumors in mice1). These findings have been followed by successive researches on cell wall components definded as zymosan2), and the effective compounds in zymosan was found as glucans3).


Human Immunodeficiency Virus Dextran Sulfate Sulfated Polysaccharide Sulfated Poly Mumps Virus 
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  1. 1.
    Lewison R, Leuchtenberger et al (1941), Action of yeast extract of transplantable and spontaneous malignant tumors in mice. Cancer Res. 1: 799–810Google Scholar
  2. 2.
    Mankowski ZT, Yamashita M et al (1957), Effect of Candida quilliermondi polysaccharide on transplantable mouse sarcome 37. Proc. Soc. Exptl. Biol. Med. 96: 79–80Google Scholar
  3. 3.
    Riggi S and DiLuzio NR (1961), Identification of a reticuloendothelial stimulating agent in zymosan. Amer. J. Physiol. 200: 297–300PubMedGoogle Scholar
  4. 4.
    Chihaga G, Maeda Y et al (1969), Inhibition of mouse sarcoma 180 by polysaccharides from Lentinus edodes ( Berk.) Sing. Nature 222: 687–688Google Scholar
  5. 5.
    Komatsu N, Okubo S et al (1969), Host-mediated antitumor action of Schizophyllan, a glucan produced by Schizophyllum commune. Gann. 60: 137–144PubMedGoogle Scholar
  6. 6.
    Taguchi T, Furue H et al (1985), End-point results of phase III study of lentinan. Jpn J Cancer Chemother 12: 366–378Google Scholar
  7. 7.
    Gerber P, Dutcher JD et al (1958), Protective effect of seaweed extracts for chicken embryos infected with influenza B or mumps virus Proc Soc Exp Biol Med 99: 590–593PubMedGoogle Scholar
  8. 8.
    Nahmias AJ, Kibrick S et al (1964), Effect of synthetic and biological polyanions on herpes simplex virus. Proc Soc Exp Biol Med 115: 993–996PubMedGoogle Scholar
  9. 9.
    Takemoto KK and Fabisch P (1964), Inhibition of herpes virus by natural and synthetic acid polysaccharides. Proc Soc Exp Biol Med 116: 140–144PubMedGoogle Scholar
  10. 10.
    Vaheri A and Cantell K (1963), The effect of heparin on herpes simplex virus. Virology 21: 661–662PubMedCrossRefGoogle Scholar
  11. 11.
    Voss H, Sensch KH et al (1974), Sulfated glycosaminoglycans as virus inhibitors: the effect of sulfated glycosaminoglycans in different virus-host systems as demonstrated by the plaque inhibition test. Zentralbl Bacterior Orig A 229: 1–36Google Scholar
  12. 12.
    Deig EF, Ehresmann DW, Hatch MT et al (1974), Inhibition of herpes-virus replication by marine algae extracts. Antimicrob Agents Chemother 6: 524–525PubMedGoogle Scholar
  13. 13.
    Nakashima H, Kido Y et al (1987), Purification and characterization of an avian myeloblastosis and human immunodeficiency virus reverse transcriptase inhibitor, sulfated polysaccharides extracted from sea algae. Antimicrob Agents Chemother 31: 1524–1528PubMedGoogle Scholar
  14. 14.
    Ito M, Baba M et al (1987), Inhibitory effect of dextran sulfate and heparin on the replication of human immunodeficiency virus (HIV) in vitro. Antiviral Res 7: 361–367PubMedCrossRefGoogle Scholar
  15. 15.
    Biesert L, Suhartono H et al (1988), Inhibition of HIV and virus replication by polysulphated polyxylan: HOE/BAY 946, a new antiviral compound. AIDS 2: 449–457PubMedCrossRefGoogle Scholar
  16. 16.
    Ito M, Baba M et al (1989), In vitro activity of mannan sulfate, a novel sulfated polysaccharide, against human immunodeficiency virus type 1 and other enveloped viruses. Eur J Clin Microbiol Infect Dis 8: 171–173PubMedCrossRefGoogle Scholar
  17. 17.
    Hamuro J, Takarada M et al (1980), Lentinan induced augmented killer T cell generation from thymocytes is due to the elevated susceptibility to helper factor(s). Int J Immunopharmacol 2: 171CrossRefGoogle Scholar
  18. 18.
    Herlyn D, Kaneko Y et al (1985), Monoclonal antibody-dependent murine macrophage-mediated cytotoxicity against human tumor is stimulated by lentinan. Jpn J Cancer Res (Gann) 76: 37–42Google Scholar
  19. 19.
    Herberman RB and Nunn-Hargrove ME (1981), Augmentation of natural killer (NK) cell activity by lentinan. In Aoki T, Urushizaki I and Tsubura E (eds), Manipulation of host defence mechanisms. Excerpta Medica Amsterdam, p 188Google Scholar
  20. 20.
    Akiyama Y and Hamura J (1981), Effect of antitumor polysaccharides on specific and non-specific immune responses and their immunological characteristics. Protein, Nucleic Acid, Enzyme 26: 208–224Google Scholar
  21. 21.
    Matsuzaki K, Yamamoto I et al, Synthesis of antitumor polysaccharides (1989), In Gebelein CG, Carraher CE and Foster VR (eds), Polymer science and technology, PLENUM 38: p 165–174Google Scholar
  22. 22.
    Tochikura ST, Nakashima H et al (1987), Suppression of human immunodeficiency virus replication by 3’-Azido-3’-deoxythymidine in various human hematopoietic cell lines in vitro: Augmentation of the effect by lentinan. Jpn J Cancer Res (Gann) 78: 583–589Google Scholar
  23. 23.
    Yoshida O, Nakashima H et al (1988), Sulfation of the immunomodulating polysaccharide lentinan: a novel strategy for antivirals to human immunodeficiency virus (HIV). Biochem Pharmacol 37: 2887–2891PubMedCrossRefGoogle Scholar
  24. 24.
    Kaneko Y, Yoshida O et al (1990), Inhibition of HIV-1 infectivity with curdlan sulfate in vitro, Biochem Pharmacol 39: 793–797PubMedCrossRefGoogle Scholar
  25. 25.
    Ehresmann DW, Deig EF et al (1979), Anti-viral properties of algal polysaccharides and related compounds. Walter de Gruyter, BerlinGoogle Scholar
  26. 26.
    Baba M, Pawels R et al (1988), Mechanism of inhibitory effect of dextran sulfate and heparin on replication of human immunodeficiency virus in vitro. Proc Natl Acad Sci USA 85: 6132–6136PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • Y. Kaneko
    • 1
  • Y. Yamamoto
    • 2
  • T. Uryu
    • 3
  1. 1.Ajinomoto Co., Inc.Chuo-ku, Tokyo 104Japan
  2. 2.Yamaguchi University School of MedicineNishi-ku, Ube, Yamaguchi 755Japan
  3. 3.Institute of Industrial ScienceUniversity of TokyoMinato-ku, Tokyo 106Japan

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