Abstract
The first finding of biological activities of polysaccharides against cancer shall be seen in the article which reported an antitumor activity of yeast extracts (De Backer, 1987), and the activity was also observed in experimental model using transplantable and spontaneous malignant tumors in mice1). These findings have been followed by successive researches on cell wall components definded as zymosan2), and the effective compounds in zymosan was found as glucans3).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Lewison R, Leuchtenberger et al (1941), Action of yeast extract of transplantable and spontaneous malignant tumors in mice. Cancer Res. 1: 799–810
Mankowski ZT, Yamashita M et al (1957), Effect of Candida quilliermondi polysaccharide on transplantable mouse sarcome 37. Proc. Soc. Exptl. Biol. Med. 96: 79–80
Riggi S and DiLuzio NR (1961), Identification of a reticuloendothelial stimulating agent in zymosan. Amer. J. Physiol. 200: 297–300
Chihaga G, Maeda Y et al (1969), Inhibition of mouse sarcoma 180 by polysaccharides from Lentinus edodes ( Berk.) Sing. Nature 222: 687–688
Komatsu N, Okubo S et al (1969), Host-mediated antitumor action of Schizophyllan, a glucan produced by Schizophyllum commune. Gann. 60: 137–144
Taguchi T, Furue H et al (1985), End-point results of phase III study of lentinan. Jpn J Cancer Chemother 12: 366–378
Gerber P, Dutcher JD et al (1958), Protective effect of seaweed extracts for chicken embryos infected with influenza B or mumps virus Proc Soc Exp Biol Med 99: 590–593
Nahmias AJ, Kibrick S et al (1964), Effect of synthetic and biological polyanions on herpes simplex virus. Proc Soc Exp Biol Med 115: 993–996
Takemoto KK and Fabisch P (1964), Inhibition of herpes virus by natural and synthetic acid polysaccharides. Proc Soc Exp Biol Med 116: 140–144
Vaheri A and Cantell K (1963), The effect of heparin on herpes simplex virus. Virology 21: 661–662
Voss H, Sensch KH et al (1974), Sulfated glycosaminoglycans as virus inhibitors: the effect of sulfated glycosaminoglycans in different virus-host systems as demonstrated by the plaque inhibition test. Zentralbl Bacterior Orig A 229: 1–36
Deig EF, Ehresmann DW, Hatch MT et al (1974), Inhibition of herpes-virus replication by marine algae extracts. Antimicrob Agents Chemother 6: 524–525
Nakashima H, Kido Y et al (1987), Purification and characterization of an avian myeloblastosis and human immunodeficiency virus reverse transcriptase inhibitor, sulfated polysaccharides extracted from sea algae. Antimicrob Agents Chemother 31: 1524–1528
Ito M, Baba M et al (1987), Inhibitory effect of dextran sulfate and heparin on the replication of human immunodeficiency virus (HIV) in vitro. Antiviral Res 7: 361–367
Biesert L, Suhartono H et al (1988), Inhibition of HIV and virus replication by polysulphated polyxylan: HOE/BAY 946, a new antiviral compound. AIDS 2: 449–457
Ito M, Baba M et al (1989), In vitro activity of mannan sulfate, a novel sulfated polysaccharide, against human immunodeficiency virus type 1 and other enveloped viruses. Eur J Clin Microbiol Infect Dis 8: 171–173
Hamuro J, Takarada M et al (1980), Lentinan induced augmented killer T cell generation from thymocytes is due to the elevated susceptibility to helper factor(s). Int J Immunopharmacol 2: 171
Herlyn D, Kaneko Y et al (1985), Monoclonal antibody-dependent murine macrophage-mediated cytotoxicity against human tumor is stimulated by lentinan. Jpn J Cancer Res (Gann) 76: 37–42
Herberman RB and Nunn-Hargrove ME (1981), Augmentation of natural killer (NK) cell activity by lentinan. In Aoki T, Urushizaki I and Tsubura E (eds), Manipulation of host defence mechanisms. Excerpta Medica Amsterdam, p 188
Akiyama Y and Hamura J (1981), Effect of antitumor polysaccharides on specific and non-specific immune responses and their immunological characteristics. Protein, Nucleic Acid, Enzyme 26: 208–224
Matsuzaki K, Yamamoto I et al, Synthesis of antitumor polysaccharides (1989), In Gebelein CG, Carraher CE and Foster VR (eds), Polymer science and technology, PLENUM 38: p 165–174
Tochikura ST, Nakashima H et al (1987), Suppression of human immunodeficiency virus replication by 3’-Azido-3’-deoxythymidine in various human hematopoietic cell lines in vitro: Augmentation of the effect by lentinan. Jpn J Cancer Res (Gann) 78: 583–589
Yoshida O, Nakashima H et al (1988), Sulfation of the immunomodulating polysaccharide lentinan: a novel strategy for antivirals to human immunodeficiency virus (HIV). Biochem Pharmacol 37: 2887–2891
Kaneko Y, Yoshida O et al (1990), Inhibition of HIV-1 infectivity with curdlan sulfate in vitro, Biochem Pharmacol 39: 793–797
Ehresmann DW, Deig EF et al (1979), Anti-viral properties of algal polysaccharides and related compounds. Walter de Gruyter, Berlin
Baba M, Pawels R et al (1988), Mechanism of inhibitory effect of dextran sulfate and heparin on replication of human immunodeficiency virus in vitro. Proc Natl Acad Sci USA 85: 6132–6136
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1990 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Kaneko, Y., Yamamoto, Y., Uryu, T. (1990). Biological Actions of Polysaccharides and Those Derivatives Against Cancer and AIDS. In: Masihi, K.N., Lange, W. (eds) Immunotherapeutic Prospects of Infectious Diseases. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76120-1_13
Download citation
DOI: https://doi.org/10.1007/978-3-642-76120-1_13
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-76122-5
Online ISBN: 978-3-642-76120-1
eBook Packages: Springer Book Archive