Skip to main content

Biological Actions of Polysaccharides and Those Derivatives Against Cancer and AIDS

  • Conference paper
Immunotherapeutic Prospects of Infectious Diseases

Abstract

The first finding of biological activities of polysaccharides against cancer shall be seen in the article which reported an antitumor activity of yeast extracts (De Backer, 1987), and the activity was also observed in experimental model using transplantable and spontaneous malignant tumors in mice1). These findings have been followed by successive researches on cell wall components definded as zymosan2), and the effective compounds in zymosan was found as glucans3).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Lewison R, Leuchtenberger et al (1941), Action of yeast extract of transplantable and spontaneous malignant tumors in mice. Cancer Res. 1: 799–810

    Google Scholar 

  2. Mankowski ZT, Yamashita M et al (1957), Effect of Candida quilliermondi polysaccharide on transplantable mouse sarcome 37. Proc. Soc. Exptl. Biol. Med. 96: 79–80

    CAS  Google Scholar 

  3. Riggi S and DiLuzio NR (1961), Identification of a reticuloendothelial stimulating agent in zymosan. Amer. J. Physiol. 200: 297–300

    PubMed  CAS  Google Scholar 

  4. Chihaga G, Maeda Y et al (1969), Inhibition of mouse sarcoma 180 by polysaccharides from Lentinus edodes ( Berk.) Sing. Nature 222: 687–688

    Google Scholar 

  5. Komatsu N, Okubo S et al (1969), Host-mediated antitumor action of Schizophyllan, a glucan produced by Schizophyllum commune. Gann. 60: 137–144

    PubMed  CAS  Google Scholar 

  6. Taguchi T, Furue H et al (1985), End-point results of phase III study of lentinan. Jpn J Cancer Chemother 12: 366–378

    CAS  Google Scholar 

  7. Gerber P, Dutcher JD et al (1958), Protective effect of seaweed extracts for chicken embryos infected with influenza B or mumps virus Proc Soc Exp Biol Med 99: 590–593

    PubMed  CAS  Google Scholar 

  8. Nahmias AJ, Kibrick S et al (1964), Effect of synthetic and biological polyanions on herpes simplex virus. Proc Soc Exp Biol Med 115: 993–996

    PubMed  CAS  Google Scholar 

  9. Takemoto KK and Fabisch P (1964), Inhibition of herpes virus by natural and synthetic acid polysaccharides. Proc Soc Exp Biol Med 116: 140–144

    PubMed  CAS  Google Scholar 

  10. Vaheri A and Cantell K (1963), The effect of heparin on herpes simplex virus. Virology 21: 661–662

    Article  PubMed  CAS  Google Scholar 

  11. Voss H, Sensch KH et al (1974), Sulfated glycosaminoglycans as virus inhibitors: the effect of sulfated glycosaminoglycans in different virus-host systems as demonstrated by the plaque inhibition test. Zentralbl Bacterior Orig A 229: 1–36

    CAS  Google Scholar 

  12. Deig EF, Ehresmann DW, Hatch MT et al (1974), Inhibition of herpes-virus replication by marine algae extracts. Antimicrob Agents Chemother 6: 524–525

    PubMed  CAS  Google Scholar 

  13. Nakashima H, Kido Y et al (1987), Purification and characterization of an avian myeloblastosis and human immunodeficiency virus reverse transcriptase inhibitor, sulfated polysaccharides extracted from sea algae. Antimicrob Agents Chemother 31: 1524–1528

    PubMed  CAS  Google Scholar 

  14. Ito M, Baba M et al (1987), Inhibitory effect of dextran sulfate and heparin on the replication of human immunodeficiency virus (HIV) in vitro. Antiviral Res 7: 361–367

    Article  PubMed  CAS  Google Scholar 

  15. Biesert L, Suhartono H et al (1988), Inhibition of HIV and virus replication by polysulphated polyxylan: HOE/BAY 946, a new antiviral compound. AIDS 2: 449–457

    Article  PubMed  CAS  Google Scholar 

  16. Ito M, Baba M et al (1989), In vitro activity of mannan sulfate, a novel sulfated polysaccharide, against human immunodeficiency virus type 1 and other enveloped viruses. Eur J Clin Microbiol Infect Dis 8: 171–173

    Article  PubMed  CAS  Google Scholar 

  17. Hamuro J, Takarada M et al (1980), Lentinan induced augmented killer T cell generation from thymocytes is due to the elevated susceptibility to helper factor(s). Int J Immunopharmacol 2: 171

    Article  Google Scholar 

  18. Herlyn D, Kaneko Y et al (1985), Monoclonal antibody-dependent murine macrophage-mediated cytotoxicity against human tumor is stimulated by lentinan. Jpn J Cancer Res (Gann) 76: 37–42

    CAS  Google Scholar 

  19. Herberman RB and Nunn-Hargrove ME (1981), Augmentation of natural killer (NK) cell activity by lentinan. In Aoki T, Urushizaki I and Tsubura E (eds), Manipulation of host defence mechanisms. Excerpta Medica Amsterdam, p 188

    Google Scholar 

  20. Akiyama Y and Hamura J (1981), Effect of antitumor polysaccharides on specific and non-specific immune responses and their immunological characteristics. Protein, Nucleic Acid, Enzyme 26: 208–224

    CAS  Google Scholar 

  21. Matsuzaki K, Yamamoto I et al, Synthesis of antitumor polysaccharides (1989), In Gebelein CG, Carraher CE and Foster VR (eds), Polymer science and technology, PLENUM 38: p 165–174

    Google Scholar 

  22. Tochikura ST, Nakashima H et al (1987), Suppression of human immunodeficiency virus replication by 3’-Azido-3’-deoxythymidine in various human hematopoietic cell lines in vitro: Augmentation of the effect by lentinan. Jpn J Cancer Res (Gann) 78: 583–589

    CAS  Google Scholar 

  23. Yoshida O, Nakashima H et al (1988), Sulfation of the immunomodulating polysaccharide lentinan: a novel strategy for antivirals to human immunodeficiency virus (HIV). Biochem Pharmacol 37: 2887–2891

    Article  PubMed  CAS  Google Scholar 

  24. Kaneko Y, Yoshida O et al (1990), Inhibition of HIV-1 infectivity with curdlan sulfate in vitro, Biochem Pharmacol 39: 793–797

    Article  PubMed  CAS  Google Scholar 

  25. Ehresmann DW, Deig EF et al (1979), Anti-viral properties of algal polysaccharides and related compounds. Walter de Gruyter, Berlin

    Google Scholar 

  26. Baba M, Pawels R et al (1988), Mechanism of inhibitory effect of dextran sulfate and heparin on replication of human immunodeficiency virus in vitro. Proc Natl Acad Sci USA 85: 6132–6136

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1990 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Kaneko, Y., Yamamoto, Y., Uryu, T. (1990). Biological Actions of Polysaccharides and Those Derivatives Against Cancer and AIDS. In: Masihi, K.N., Lange, W. (eds) Immunotherapeutic Prospects of Infectious Diseases. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76120-1_13

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-76120-1_13

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-76122-5

  • Online ISBN: 978-3-642-76120-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics