Biological Actions of Polysaccharides and Those Derivatives Against Cancer and AIDS
The first finding of biological activities of polysaccharides against cancer shall be seen in the article which reported an antitumor activity of yeast extracts (De Backer, 1987), and the activity was also observed in experimental model using transplantable and spontaneous malignant tumors in mice1). These findings have been followed by successive researches on cell wall components definded as zymosan2), and the effective compounds in zymosan was found as glucans3).
KeywordsHuman Immunodeficiency Virus Dextran Sulfate Sulfated Polysaccharide Sulfated Poly Mumps Virus
Unable to display preview. Download preview PDF.
- 1.Lewison R, Leuchtenberger et al (1941), Action of yeast extract of transplantable and spontaneous malignant tumors in mice. Cancer Res. 1: 799–810Google Scholar
- 2.Mankowski ZT, Yamashita M et al (1957), Effect of Candida quilliermondi polysaccharide on transplantable mouse sarcome 37. Proc. Soc. Exptl. Biol. Med. 96: 79–80Google Scholar
- 4.Chihaga G, Maeda Y et al (1969), Inhibition of mouse sarcoma 180 by polysaccharides from Lentinus edodes ( Berk.) Sing. Nature 222: 687–688Google Scholar
- 6.Taguchi T, Furue H et al (1985), End-point results of phase III study of lentinan. Jpn J Cancer Chemother 12: 366–378Google Scholar
- 11.Voss H, Sensch KH et al (1974), Sulfated glycosaminoglycans as virus inhibitors: the effect of sulfated glycosaminoglycans in different virus-host systems as demonstrated by the plaque inhibition test. Zentralbl Bacterior Orig A 229: 1–36Google Scholar
- 18.Herlyn D, Kaneko Y et al (1985), Monoclonal antibody-dependent murine macrophage-mediated cytotoxicity against human tumor is stimulated by lentinan. Jpn J Cancer Res (Gann) 76: 37–42Google Scholar
- 19.Herberman RB and Nunn-Hargrove ME (1981), Augmentation of natural killer (NK) cell activity by lentinan. In Aoki T, Urushizaki I and Tsubura E (eds), Manipulation of host defence mechanisms. Excerpta Medica Amsterdam, p 188Google Scholar
- 20.Akiyama Y and Hamura J (1981), Effect of antitumor polysaccharides on specific and non-specific immune responses and their immunological characteristics. Protein, Nucleic Acid, Enzyme 26: 208–224Google Scholar
- 21.Matsuzaki K, Yamamoto I et al, Synthesis of antitumor polysaccharides (1989), In Gebelein CG, Carraher CE and Foster VR (eds), Polymer science and technology, PLENUM 38: p 165–174Google Scholar
- 22.Tochikura ST, Nakashima H et al (1987), Suppression of human immunodeficiency virus replication by 3’-Azido-3’-deoxythymidine in various human hematopoietic cell lines in vitro: Augmentation of the effect by lentinan. Jpn J Cancer Res (Gann) 78: 583–589Google Scholar
- 25.Ehresmann DW, Deig EF et al (1979), Anti-viral properties of algal polysaccharides and related compounds. Walter de Gruyter, BerlinGoogle Scholar