Advertisement

Alcohol, Nutrients, and Pancreatic Function

  • H. Worning

Abstract

The subject of this chapter — alcohol, nutrients, and pancreatic function — is relevant both from a physiological point of view and in connection with the pathophysiology of pancreatic diseases, in that alcohol and nutritive factors have been claimed to be of etiological significance for acute pancreatitis, chronic pancreatitis, and also pancreatic cancer.

Keywords

Chronic Pancreatitis Pancreatic Juice Pancreatic Enzyme Pancreatic Secretion Pancreatic Function 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Adelson JW, Miller PE (1989) Heterogeneity of the exocrine pancreas. Am J Physiol 256:G817–825PubMedGoogle Scholar
  2. Adler G, Müllenhoff A, Koop I, Bozkurt T, Göke B, Beglinger C, Arnold R (1988) Stimulation of pancreatic secretion in man by a protease inhibitor (camostate). Eur J Clin Invest 18:98–104PubMedCrossRefGoogle Scholar
  3. Beaudoin AR (1988) The asynchronous transport of secretory proteins in the exocrine pancreas. Compatibility with the hypothesis of a paragranular pathway. Int J Pancreatol 3:409–414PubMedGoogle Scholar
  4. Beaudoin AR, St-Jean P, Grondin G (1989) Pancreatic juice composition: new views about the cellular mechanisms that control the concentration of digestive and nondigestive proteins. Dig Dis 7:210–220PubMedCrossRefGoogle Scholar
  5. Boyd EJS, Dunbar J, Clarke G, Wormsley KG (1986) Dissociation between pancreatic enzyme secretory and synthetic dose-responses to cholecystokinin in man. Int J Pancreatol 1:29–37PubMedGoogle Scholar
  6. Cantor P, Petronijevic L, Pedersen JF, Worning H (1986a) Cholecystokinetic and pancreozymic effect of O-sulfated gastrin compared with nonsulfated gastrin and cholecystokinin. Gastroenterology 91:1154–1163PubMedGoogle Scholar
  7. Cantor P, Petronijevic L, Worning H (1986b) Plasma cholecystokinin concentrations in patients with advanced chronic pancreatitis. Pancreas 1:488–493PubMedCrossRefGoogle Scholar
  8. Cantor P, Olsen O, Gertz BJ, Gjørup I, Worning H (1991a) Inhibition of cholecystokinin (CCK)-stimulated pancreaticobiliary output in man by CCK-receptor antagonist MK-329. Gut (in press)Google Scholar
  9. Cantor P, Mortensen PE, Myhre J, Gjørup I, Worning H, Stahl E, Survill TT (1991b) The effect of the cholecystokinin receptor antagonist MK-329 on meal-stimulated pancreaticobiliary output and gastrointestinal motility in man. Gastroenterology (in press)Google Scholar
  10. Dagorn JC, Sahel J, Sarles H (1977) Nonparallel secretion of enzymes in human duodenal juice and pure pancreatic juice collected by endoscopic retrograde catheterization of the papilla. Gastroenterology 73:42–45PubMedGoogle Scholar
  11. Dlugosz J, Fölsch UR, Czajkowski A, Gabryelewicz A (1988) Feedback regulation of stimulated pancreatic enzyme secretion during intraduodenal perfusion of trypsin in man. Eur J Clin Invest 18:267–272PubMedCrossRefGoogle Scholar
  12. Fried M, Jansen JB, Harpole T, Taylor IL, Lamers CB, Reedy T, Elashoff J, Meyer JH (1989) Pancreatobiliary responses to an intragastric amino acid meal: comparison to albumin, dextrose, and a maximal cholecystokinin stimulus. Gastroenterology 97:1544–1549PubMedGoogle Scholar
  13. Gjørup I, Dueholm S, Andersen B, Burcharth F (1990) Ethanol in pancreatic juice after oral and intravenous administration. Gut 31:1411–1413.PubMedCrossRefGoogle Scholar
  14. Gullo L, Priori P, Pezzilli R, Biliotti G, Mattioli G, Barbara L (1988) Pancreatic secretory response to ordinary meals: studies with pure pancreatic juice. Gastroenterology 94:428–433PubMedGoogle Scholar
  15. Hajnal F, Flores MC, Valenzuela JE (1989) Effect of alcohol and alcoholic beverages on nonstimulated pancreatic secretion in humans. Pancreas 4:486–491PubMedCrossRefGoogle Scholar
  16. Halgreen H, Pedersen NT, Worning H (1986) Symptomatic effect of pancreatic enzyme therapy in patients with chronic pancreatitis. Scand J Gastroenterol 21:104–108PubMedCrossRefGoogle Scholar
  17. Harada H, Ono A, Yamamoto N, Ikubo I, Negron A, Hayashi T, Sato T, Mishima K, Kimura I (1978) Studies on human pure pancreatic juice collected by endoscopic retrograde catheterization of the papilla. Gastroenterol Jpn 13:383–389PubMedGoogle Scholar
  18. Harada H, Yabe H, Hanafusa E, Ikubo I, Takeda M, Hayashi T, Negron A, Ono A, Yamamoto N, Mishima K, Kimura I (1979) Analysis of pure pancreatic juice in patients with chronic alcoholism. Gastroenterol Jpn 14:458–466PubMedGoogle Scholar
  19. Ihse I, Lilja P, Lundqvist I (1977) Feedback regulation of pancreatic enzyme secretion by intestinal trypsin in man. Digestion 15:303–308PubMedCrossRefGoogle Scholar
  20. Isaksson G, Ihse I (1983) Pain reduction by an oral pancreatic enzyme preparation in chronic pancreatitis. Dig Dis Sci 28:97–102PubMedCrossRefGoogle Scholar
  21. Kölbel CBM, Singer MV, Möhle T, Heinzel C, Eysselein V, Goebell H (1986) Action of intravenous ethanol and atropine on the secretion of gastric acid, pancreatic enzymes, and bile acids and the motility of the upper gastrointestinal tract in nonalcoholic humans. Pancreas 1:211–218PubMedCrossRefGoogle Scholar
  22. Liebow C (1988) Nonparallel pancreatic secretion: its meaning and implications. Pancreas 3:343–351PubMedCrossRefGoogle Scholar
  23. Liehr R-M, Herrmann M-E, Emde C, Hopert R, Riecken E-O (1989) High amount of dietary carbohydrate does not cause an adaptational increase of stimulated human pancreatic amylase secretion. Int J Pancreatol 4:419–430PubMedGoogle Scholar
  24. Mortensen PE, Myhre J, Petronijevic L, Holst JJ, Olsen O, Cantor P, Worning H (1991) Somatostatin-14 effect on normal human exocrine pancreatic secretion after ingestion of a normal solid meal. Scand J Gastroenterol (in press)Google Scholar
  25. Mössner J, Wresky HP, Kestel W, Zeeh J, Regner U, Fischbach W (1989) Influence of treatment with pancreatic extracts on pancreatic enzyme secretion. Gut 30:1143–1149PubMedCrossRefGoogle Scholar
  26. Olsen O, Schaffalitzky de Muckadell OB, Cantor P (1986) The significance of plasma CCK and secretin in the oleate-stimulated pancreatico-biliary secretion in man. Int J Pancreatol 1:363–372PubMedGoogle Scholar
  27. Olsen O, Ainsworth M, Schaffalitzky de Muckadell OB, Cantor P (1989) Effects of oleic acid and oleyl alcohol on cholecystokinin and secretin in plasma and pancreatobiliary secretion. Scand J Gastroenterol 24:529–532PubMedCrossRefGoogle Scholar
  28. Owyang CH, Louie DS, Tatum D (1986) Feedback regulation of pancreatic enzyme secretion. Suppression of cholecystokinin release by trypsin. J Clin Invest 77:2042–2047PubMedCrossRefGoogle Scholar
  29. Renner IG, Rinderknecht H, Valenzuela JE, Douglas AP (1980) Studies of pure pancreatic secretions in chronic alcoholic subjects without pancreatic insufficiency. Scand J Gastroenterol 15:241–244PubMedCrossRefGoogle Scholar
  30. Rinderknecht H, Renner IG, Douglas AP, Adham NF (1978) Proflies of pure pancreatic secretions obtained by direct pancreatic duct cannulation in normal healthy human subjects. Gastroenterology 75:1083–1089PubMedGoogle Scholar
  31. Rinderknecht H, Stace NH, Renner IG (1985) Effects of chronic alcohol abuse on exocrine pancreatic secretion in man. Dig Dis Sci 30:65–71PubMedCrossRefGoogle Scholar
  32. Rothman SS (1975) Protein transport by the pancreas. Science 190:747–753PubMedCrossRefGoogle Scholar
  33. Schaffalitzky de Muckadell OB, Olsen O, Cantor P, Magid E (1986) Concentrations of secretin and CCK in plasma and pancreatico-biliary secretion in response to intraduodenal acid and fat. Pancreas 1:536–543CrossRefGoogle Scholar
  34. Singh M, Simsek H (1990) Ethanol and the pancreas. Gastroenterology 98:1051–1062PubMedCrossRefGoogle Scholar
  35. Slaff J, Jacobson D, Randall Tillman C, Curington C, Toskes P (1984) Protease-specific suppression of pancreatic exocrine secretion. Gastroenterology 87:44–52PubMedGoogle Scholar
  36. Wilson JS, Korsten MA, Pirola RC (1989a) Alcohol-induced pancreatic injury (part 1). Int J Pancreatol 4:109–125PubMedGoogle Scholar
  37. Wilson JS, Korsten MA, Pirola RC (1989b) Alcohol-induced pancreatic injury (part 2). Evolution of pathogenetic theories. Int J Pancreatol 4:233–250PubMedGoogle Scholar
  38. Worning H (1989) Etiologic aspects of chronic pancreatitis. Int J Pancreatol 5:1–9PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • H. Worning
    • 1
  1. 1.Medical Department F, Glostrup HospitalUniversity of CopenhagenGlostrupDenmark

Personalised recommendations