Future Aspects of Enzyme Replacement Therapy

  • E. P. DiMagno
Conference paper

Abstract

At present, there are two indications for the use of pancreatic enzymes to treat patients with chronic pancreatitis: the treatment of malabsorption and the treatment of pain. Each treatment indication may require different enzyme formulations.

Keywords

Lipase Pancreatitis Bicarbonate Cimetidine Steatorrhea 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. DiMagno EP (1979) Medical treatment of pancreatic insufficiency. Mayo Clin Proc 54:435–442PubMedGoogle Scholar
  2. DiMagno EP, Go VLW, Summerskill WHJ (1973) Relations between pancreatic enzyme outputs and malabsorption in severe pancreatic insufficiency. N Engl J Med 288:813–815PubMedCrossRefGoogle Scholar
  3. DiMagno EP, Malagelada J-R, Go VLW, Moertel CG (1977) Fate of orally ingested enzymes in pancreatic insufficiency: comparison of two dosage schedules. N Engl J Med 296:1318–1322PubMedCrossRefGoogle Scholar
  4. Regan PT, Malagelada J-R, DiMagno EP, Glanzman SL, Go VLW (1977) Comparative effects of antacids, Cimetidine, and enteric coating on the therapeutic response to oral enzymes in severe pancreatic insufficiency. N Engl J Med 297:854–858PubMedCrossRefGoogle Scholar
  5. Regan PT, Phillips SF, DiMagno EP (1978) Pancreatic insufficiency and Menetrier’s disease: report of a case with clinical response to pancreatic enzyme replacement. Am J Dig Dis 23:759–762PubMedCrossRefGoogle Scholar
  6. Regan PT, Malagelada J-R, DiMagno EP, Go VLW (1979) Reduced intraluminal bile acid concentrations and fat maldigestion in pancreatic insufficiency: correction by treatment. Gastroenterology 77:285–289PubMedGoogle Scholar
  7. Slaff J, Jacobson D, Tillman CR, Curington C, Toskes P (1984) Protease-specific suppression of pancreatic exocrine secretion. Gastroenterology 87:44–52PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • E. P. DiMagno
    • 1
  1. 1.Mayo Medical ClinicRochesterUSA

Personalised recommendations