The Biology of the Connective Tissue of the Human Optic Nerve Head
Over the past several years, we have characterized the macromolecular components of the extracellular matrix of the lamina cribrosa of the human optic nerve head. We have hypothesized that age-related changes and individual differences in the molecular composition of this tissue may underlie the glaucomatous process and contribute to the degeneration of optic nerve fibers. This chapter will review some of the data that we have presented in support of this hypothesis.
KeywordsPermeability Fibril Macromolecule Glaucoma Compressibility
Unable to display preview. Download preview PDF.
- 1.Hay ED (1983) Cell biology of extracellular matrix, 2nd edn. Plenum Press, New York, pp 5, 95Google Scholar
- 5.Coulehan JL, Helzlsouer KJ, Rogers KD, Brown SJ (1980) Racial differences in intraocular tension and glaucoma surgery. Am J Epidemiology 11:759Google Scholar
- 6.Merrit JC, Perry DD, Ellison PS (1985) Effects of pilocarpine in blacks with open angle glaucoma. Glaucoma 7:127Google Scholar
- 8.Andrzejewska W, Hernandez MR, Neufeld AH (1989) Racial differences in the extracellular matrix of the lamina cribrosa. Invest Ophthalmol Vis Sci (ARVO Suppl) 30 (3):428Google Scholar
- 14.Hernandez MR, Hanley NM, Neufeld AH (1989) Gene expression for type I collagen and elastin in human lamina cribrosa cells in culture. Invest Ophthalmol Vis Sci (ARVO Suppl) 30 (3): 201Google Scholar