In Vivo Measurement of Aqueous Flare in Human Eyes. Diurnal Variation and Drug Effects
Recently, a new instrument which can quantitatively measure aqueous flare in the anterior chamber in vivo has been developed. This instrument, the laser flare-cell meter, is easy to use and sufficiently sensitive in measuring faint flare which cannot be detected by conventional slit-lamp illumination (Sawa at al. 1988). In the present study, this instrument was employed to reexamine Anjou’s unconfirmed but interesting finding that the aqueous flare in normal human eyes shows diurnal variation (Anjou 1961) similar to intraocular pressure (IOP) (Drance 1960; Phelps et al. 1974), aqueous flow (Ericson 1958; Reiss et al. 1984) and outflow facility (Boyd and McLeod 1964; Takeda and Azuma 1978).
KeywordsDiurnal Variation Intraocular Pressure Anterior Chamber Aqueous Flow Laser Trabeculoplasty
Unable to display preview. Download preview PDF.
- Anjou CIN (1961) Physiological variations of the aqueous flare density in normal human eyes. Acta Ophthalmol 39:525–539Google Scholar
- Anjou CIN, Krakau CET (1960) A photographic method for measuring the aqueous flare of the eye in normal and pathological conditions. Acta Ophthalmol 38:178–224Google Scholar
- Araie M, Sawa M, Nagataki S et al. (1980) Aqueous humor dynamics in man as studied by oral fluorescein. Jpn J Ophthalmol 24:346–362Google Scholar
- Araie M, Takase M (1981) Effects of various drugs on aqueous humor dynamics in man. Jpn J Ophthalmol 25:91–111Google Scholar
- Bengtsson E (1975) The inhibiting effect of indo-methacin on the disruption of the blood-aqueous barrier in the rabbit eye. With a technical note: Krakau CET, Ohman R: Measurement of the aqueous flare. Invest Ophthalmol 14:306–312Google Scholar
- Bill A (1981) Effects of ALO2145 on ocular blood flow. Data on file, Alcon LaboratoriesGoogle Scholar
- Ericson LA (1958) Twenty-four hourly variations in the inflow of the aqueous humor. Acta Ophthalmol 36:381–385Google Scholar
- Neufeld AH (1984) The mechanisms of action of adrenergic drugs in the eye. In: Drance SM, Neufeld AH (eds) Glaucoma: Applied pharmacology in medical treatment. Grune & Stratton, Inc., Orlando, New York, pp 277–324Google Scholar
- Sakuma A (1977) Pharmacometrics I. Tokyo University Press, Tokyo, pp 133–145Google Scholar
- Takase M (1969) Studies on the protein content in the aqueous humor of the living rabbits. I A slit-lamp microphotometer and its application. Acta Soc Ophthalmol Jpn 73:2649–2658Google Scholar