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Multiple Dose, Dose Response Over 24 Hours Using the Novel, Topical Carbonic Anhydrase Inhibitor MK-927

  • P. J. Airaksinen
  • A. Tuulonen
  • E. A. Lippa
Conference paper

Abstract

The multiple dose, dose response curve of the topical carbonic anhydrase inhibitor MK-927 administered every 12 h was investigated in 20 patients with primary open-angle glaucoma or ocular hypertension. Three concentrations of MK-927 (2%, 1%, and 0.5%) and placebo were administered in a double-blind randomized, placebo-controlled, 14 day parallel study by means of multiple 25 h diurnal intraocular pressure curves measured at one center within the framework of a larger, five center trial. Fourteen days of dosing with 2% MK-927 given every 12 h significantly decreases intraocular pressure through 12 h postdose (peak mean decrease in the worse eye of 7.4 mm Hg and mean percent decrease of 26% at 2 h postdose) compared to prestudy. A numerical dose response relationship was observed and 0.5% MK-927 given twice daily appears to be a minimal-effect dose.

Keywords

Ocular Hypertension Ophthalmic Solution Active Carbonic Anhydrase Carbonic Anhydrase Inhibitor Benzalkonium Chloride 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • P. J. Airaksinen
    • 1
  • A. Tuulonen
    • 1
  • E. A. Lippa
    • 2
  1. 1.OuluFinland
  2. 2.West PointUSA

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