Direct Measurement of Retinal Nerve Fiber Layer Thickness

  • R. N. Weinreb
  • A. W. Dreher
Conference paper


Several methods for clinically evaluating the retinal nerve fiber layer in glaucoma have been reported. Among them are red-free ophthalmoscopy (Hoyt 1973), nerve fiber layer photography with black and white film (Sommer 1984), computer enhancement of nerve fiber layer photographs (Peli 1986), and computerized images to measure the relative height of the peripapillary nerve fiber layer surface (Caprioli 1989). We have been attempting to develop a new technique for direct measurement of retinal nerve fiber layer thickness. This technique is based on the assumption that the nerve fiber layer has birefringent properties similar to those found for the Henle fibers in the macula region (Delori 1979; Brink 1988).


Retinal Nerve Fiber Layer Retinal Nerve Fiber Layer Thickness Discrete Fourier Analysis Nerve Fiber Layer Defect Computer Enhancement 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Brink HB, van Blokland GJ (1988) Birefringence of the human foveal area assessed in vivo with Mueller-matrix ellipsometry. J Opt Soc Am 5:49–57CrossRefGoogle Scholar
  2. 2.
    Caprioli J, Miller JM (1989) Measurement of relative nerve fiber layer surface height in glaucoma. Ophthalmology 96:633–641PubMedGoogle Scholar
  3. 3.
    Delori FC, Webb RH, Parker JS (1979) Macular birefringence. Invest Ophthalmol Vis Sci (Suppl) 19:53Google Scholar
  4. 4.
    Dreher AW, Bille JF, Weinreb RN (1989) Active-optical resolution improvement of the laser tomographic scanner. Applied Optics 28:804–808PubMedCrossRefGoogle Scholar
  5. 5.
    Hoyt WF, Frisen L, Newman NM (1973) Fundus-copy of nerve fiber layer defects in glaucoma. Invest Ophthalmol 12:814–829PubMedGoogle Scholar
  6. 6.
    Peli E, Hedges TR, Schwartz B (1986) Computerized enhancement of retinal nerve fiber layer. Acta Ophthalmologica 64:113–122PubMedCrossRefGoogle Scholar
  7. 7.
    Reiter K, Bille JF, Dreher AW, Hemenger RP, Weinreb RN (1990/In Press) Retinal nerve fiber layer thickness measurement by Fourier-ellip-sometry using the laser tomographic scanner. Biomedical OpticsGoogle Scholar
  8. 8.
    Sommer A, Quigley HA, Robin AL, Miller NR, Katz J, Arkell S (1984) Evaluation of nerve fiber layer assessment. Arch Ophthalmol 102:1766–1771PubMedCrossRefGoogle Scholar
  9. 9.
    Weinreb RN, Dreher AW, Coleman A, Quigley H, Shaw B, Reiter K (1990) Histopathologic Validation of Fourier-Ellipsometry Measurements of Retinal Nerve Fiber Layer Thickness. Arch Ophthalmol 108:557–560PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • R. N. Weinreb
    • 1
  • A. W. Dreher
    • 1
  1. 1.La JollaUSA

Personalised recommendations