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Der Einfluß von Flurbiprofen-0,03%-Augentropfen auf die Störung der Blut-Kammerwasserschranke nach Hinterkammerlinsenimplantation

  • M. Diestelhorst
  • F. Aspacher
  • W. Konen
  • G. K. Krieglstein
Conference paper

Zusammenfassung

Unter Anwendung der computerassistierten Vorderkammerfluorophoto-metrie wurde der Einfluß von Flurbiprofenaugentropfen auf die Blut-/Kammerwasser-schranke nach Phakoemulsifikation und Hinterkammerlinsenimplantation untersucht. Jeweils 10 Patienten erhielten randomisiert Flurbiprofen-0,03%-Augentropfen oder Vehikel am operierten Auge 5mal täglich appliziert. Steroide oder andere, nicht-steroidale Antiphlogistika wurden während des Untersuchungsintervalls weder systemisch, noch lokal therapiert. Die fluorophotometrische Kontrolle erfolgte am Tag vor Operation und am 5. postoperativen Tag. Fluoreszein-Natrium 10% wurde intravenös appliziert (7 mg/kg Körpergewicht). Die Varianzanalyse bestätigte den signifikant protektiven Einfluß von Flurbiprofen-0,03%-Augentropfen auf die Blut-/Kammerwasserschranke nach Hinterkammerlinsenimplantation sowohl am operierten (p<0,001) als auch am nicht-operierten Partnerauge (p<0,01). Die spaltlampenmikroskopischen Befunde stehen in Einklang mit den fluoro-photometrischen Daten.

Eine kontrollierte fluorophotometrische Studie

Summary

Preoperative and postoperative anterior chamber fluorophotometry was performed after intravenous administration of fluorescein sodium in patients undergoing extra-capsular cataract and posterior chamber lens implantation. The administration of topical 0.03% flurbiprofen sodium solution before and after surgery significantly decreased the breakdown of the blood-aqueous-barrier compared with vehicle at each time period, as measured by computerized fluorophotometry. Corticosteroids were not given to any patient throughout the duration of the study. The statistical results (ANOVA) correlated well with the slitlamp observations of postoperative ocular inflammation. The protective influence of flurbiprofen 0.03% natrium solution on the breakdown of the blood-aqueous-barrier was statistically significant (p<0.001).

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Copyright information

© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • M. Diestelhorst
    • 1
  • F. Aspacher
    • 1
  • W. Konen
    • 1
  • G. K. Krieglstein
    • 1
  1. 1.Universitäts-Augenklinik KölnKöln 41Deutschland

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