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Suppression of Host Resistance by Antigens of Cryptococcus Neoformans

  • T. R. Kozel
Conference paper
Part of the NATO ASI Series book series (ASIH, volume 53)

Abstract

Normal immune fonction is a critical factor in resistance to the opportunistic yeast Cryptococcus neoformans. Disseminated cryptococcosis is most commonly associated with underlying illness which predisposes to disease. Patients with neoplastic disease, particularly chronic lymphatic leukemia, Hodgkin’s disease, chronic myelogenous leukemia and multiple myeloma, are at particular risk. Other risk factors include collagen diseases, sarcoidiosis, and immunosuppression associated with organ transplantation. More recently, the Acquired Immunodeficiency Disease Syndrome (AIDS) has emerged as the most important predisposing condition for development of disseminated cryptococcosis. Patients with AIDS have a number of immunological defects; the specific deficiency that accounts for the high incidence of cryptococcosis in AIDS patient is not known. An area of current interest is the extent to which the yeast is able to modulate the host resistance. the effects of the yeast on host resistance may be a contributing factor to the progression of disease in immunocompromised individuals.

Keywords

Host Resistance Cryptococcal Meningitis Capsular Polysaccharide Complement Cascade Alternative Complement Pathway 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • T. R. Kozel
    • 1
  1. 1.University of NevadaRenoUSA

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