Suppression of Host Resistance by Antigens of Cryptococcus Neoformans
Normal immune fonction is a critical factor in resistance to the opportunistic yeast Cryptococcus neoformans. Disseminated cryptococcosis is most commonly associated with underlying illness which predisposes to disease. Patients with neoplastic disease, particularly chronic lymphatic leukemia, Hodgkin’s disease, chronic myelogenous leukemia and multiple myeloma, are at particular risk. Other risk factors include collagen diseases, sarcoidiosis, and immunosuppression associated with organ transplantation. More recently, the Acquired Immunodeficiency Disease Syndrome (AIDS) has emerged as the most important predisposing condition for development of disseminated cryptococcosis. Patients with AIDS have a number of immunological defects; the specific deficiency that accounts for the high incidence of cryptococcosis in AIDS patient is not known. An area of current interest is the extent to which the yeast is able to modulate the host resistance. the effects of the yeast on host resistance may be a contributing factor to the progression of disease in immunocompromised individuals.
KeywordsHost Resistance Cryptococcal Meningitis Capsular Polysaccharide Complement Cascade Alternative Complement Pathway
Unable to display preview. Download preview PDF.
- Blackstock R, Hernandez NC (1989) Characterization of the macrophage subset affected and its response to a T suppressor factor ( TsFmp) found in cryptococcosis. Infect Immun 57: 2931–2937Google Scholar
- Diamond RD, May JE, Kane MA, Frank MM, Bennett JE (1974) The role of the classical and alternative complement pathways in host defenses against Cryptococcus neoformans infection. J Immunol 112:2260-.2270Google Scholar
- Kozel TR, Cazin J Jr (1974) Induction of humoral antibody response by soluble polysaccharide of Cryptococcus neoformans. Mycopathol Mycol App154: 21–30Google Scholar
- Murphy JW, Moorhead JW (1982) Regulation of cell-mediated immunity in cryptococcosis. I. Induction of specific afferent T suppressor cells by cryptococcal antigen. J Immunol 128: 276–283Google Scholar
- Murphy JW, Mosley RL, Moorhead JW (1983) Regulation of cell-mediated immunity in cryptococosis. II. Characterization of first-order T-suppressor cells ( Tsl) and induction of second-order suppressor cells. J Immunol 130: 2876–2881Google Scholar