Mouse Monoclonal Antibodies Against Candida Albicans and Cryptococcus Neoformans
Specific antibodies are necessary for the rapid identification of pathogenic yeasts, the elucidation of the structure of serotypic specific epitopes, and the detection of circulating antigens in patients with disseminated mycoses. Monoclonal antibodies (MAbs) are presently the most efficient probe for these purposes. This review presents the main results on the production and characterization of monoclonal antibodies directed against Candida albicans and Cryptococcus neoformans which are responsible for the major yeast infections in immunocompromised patients.
KeywordsCandida Albicans Candida Species Germ Tube Cryptococcus Neoformans Capsular Polysaccharide
Unable to display preview. Download preview PDF.
- Fukazawa Y, Shinoda T, Nishikawa A, Kagaya K, Yonezawa Y (1976) Serological and immunological studies of the serotypes of Candida albicans. In: Iwata K (Ed), Yeasts and yeast-like microorganisms in medical science. Tokyo University Press, Tokyo, p 213Google Scholar
- Munoz C, Mazie JC, Delga JM, Dupont B, Latgé JP, Drouhet E (1988) Monoclonal antibodies anti-Candida albicans mannan and anti Aspergillus fumigatus galactomannan. In: Drouhet E, Cole GT, de Repentigny L, Latgé JP, Dupont B (Eds) Fungal antigens. Plenum Press, New York London, p 213CrossRefGoogle Scholar
- Reiss E, Cherniak R, Eby R, Kaufman L (1984) Enzyme immunoassay detection of IgM to galactoxylomannan of Cryptococcus neofonnans. Diag Immunol 2: 109–115Google Scholar
- Shinoda T, Suzuki Y, Ikeda R, Nishikawa A (1988) Production and serological characterization of monoclonal antibodies against Cryptococcus neofonnans serotype A capsular polysaccharide. Xth Congress of the ISHAM, Barcelona, July 1988, Abstract P-214Google Scholar
- Sundstrom PM, Tam MR, Nichols ET, Kenny GE (1988) Antigenic differences in the surface mannoproteins of Candida albicans as revealed by monoclonal antibodies. Inf Immun 56: 601–606Google Scholar