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Development of a Reliable Measure for Determining Nitrate Exposure for Use in Epidemiological Studies

  • Conference paper
Nitrate Contamination

Part of the book series: NATO ASI Series ((ASIG,volume 30))

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Abstract

Regardless of dose or matrix, 24-h urinary nitrate reliably accounts for 50 to 60% of daily nitrate ingestion, except in those individuals who are immune stimulated and endogenously synthesize nitrate and those who are achlorhydric and lose a further 23% of dietary nitrate to bacterial metabolism in the stomach. For epidemiological studies the most reliable method of determining the nitrate exposure of a population is by the analysis of 24-h urine samples from healthy volunteers. Unhealthy volunteers should not be recruited.

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Author information

Authors and Affiliations

  1. Pathology Division, PHLS-CAMR, Porton Down, Salisbury, SP4 OJG, UK

    P. J. Packer, P. R. Randell, S. N. Duncan, B. Van Acker, P. I. Reed, M. H. Thompson, M. J. Hill & S. A. Leach

Authors
  1. P. J. Packer
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  2. P. R. Randell
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  3. S. N. Duncan
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  4. B. Van Acker
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  5. P. I. Reed
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  6. M. H. Thompson
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  7. M. J. Hill
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  8. S. A. Leach
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Editor information

Editors and Affiliations

  1. Department of Civil Engineering, University of Nebraska-Lincoln, Lincoln, Nebraska, 68588-0531, USA

    Istvan Bogárdi  & Wilma G. Ennenga  & 

  2. University of Nebraska Water Center, Lincoln, Nebraska, 68583-0844, USA

    Robert D. Kuzelka

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© 1991 Springer-Verlag Berlin Heidelberg

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Packer, P.J. et al. (1991). Development of a Reliable Measure for Determining Nitrate Exposure for Use in Epidemiological Studies. In: Bogárdi, I., Kuzelka, R.D., Ennenga, W.G. (eds) Nitrate Contamination. NATO ASI Series, vol 30. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76040-2_21

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  • DOI: https://doi.org/10.1007/978-3-642-76040-2_21

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-76042-6

  • Online ISBN: 978-3-642-76040-2

  • eBook Packages: Springer Book Archive

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