Development of a Reliable Measure for Determining Nitrate Exposure for Use in Epidemiological Studies

  • P. J. Packer
  • P. R. Randell
  • S. N. Duncan
  • B. Van Acker
  • P. I. Reed
  • M. H. Thompson
  • M. J. Hill
  • S. A. Leach
Conference paper
Part of the NATO ASI Series book series (volume 30)

Abstract

Regardless of dose or matrix, 24-h urinary nitrate reliably accounts for 50 to 60% of daily nitrate ingestion, except in those individuals who are immune stimulated and endogenously synthesize nitrate and those who are achlorhydric and lose a further 23% of dietary nitrate to bacterial metabolism in the stomach. For epidemiological studies the most reliable method of determining the nitrate exposure of a population is by the analysis of 24-h urine samples from healthy volunteers. Unhealthy volunteers should not be recruited.

Keywords

Catalysis Acidity Nitrite Hunt Cimetidine 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • P. J. Packer
    • 1
  • P. R. Randell
    • 1
  • S. N. Duncan
    • 1
  • B. Van Acker
    • 1
  • P. I. Reed
    • 1
  • M. H. Thompson
    • 1
  • M. J. Hill
    • 1
  • S. A. Leach
    • 1
  1. 1.Pathology DivisionPHLS-CAMRSalisburyUK

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