Abstract
T lymphocytes develop and mature within the thymus gland [1]. It seems likely that the thy-mus has evolved as a site for the provision of efficient signalling of T-cell maturation. In addition, recent studies have indicated the importance of antigen expression (especially expression of self-MHC antigens) by the thymic environment in shaping the T-cell receptor repertoire by positive selection, i.e., selection of T cells with useful receptors, and negative selection, i.e., removal of potentially autoreactive cells [2].
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© 1990 Spinger-Verlag Berlin Heidelberg
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Wagner, H., Heeg, K. (1990). Mechanisms of T-Cell Activation. In: Mertelsmann, R. (eds) Lymphohaematopoietic Growth Factors in Cancer Therapy. ESO Monographs. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76037-2_3
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DOI: https://doi.org/10.1007/978-3-642-76037-2_3
Publisher Name: Springer, Berlin, Heidelberg
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