Arbeitsstoffexposition und Krebsrisiko im Bereich von Mundhöhle, Rachen und Kehlkopf

  • H. Maier
  • A. Dietz
  • U. Gewelke
  • W.-D. Heller


Die seit 1978 in der Bundesrepublik Deutschland beobachtete Zunahme beruflicher Krebserkrankungen [11, 66] hat in den letzten Jahren zu einem verstärkten Interesse hinsichtlich des Stellenwertes einer beruflichen Schadstoffexposition als Risikofaktor für die Entstehung bösartiger Tumoren des oberen Atmungs- und Verdauungstraktes geführt.


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  1. 1.
    Acheson ED, Cowdell H, Hadfield E, Macbeth RG (1970) Nasal cancer in woodworkers in the furniture industry. Br Med J II: 587–596Google Scholar
  2. 2.
    Ahlborg G, Hogstedt C, Sundell L, Aman CG (1981) Laryngeal cancer and pickling house vapors. Scand J Work Environ Health 7:239–240PubMedCrossRefGoogle Scholar
  3. 3.
    Ahrens W, Jockel KH, Patzak W, Eisner G (1989) Eine Fall-Kontrollstudie zu Risikofaktoren des Larynxkarzinoms. Kongreßbericht der 29. Jahrestagung der Deutschen Gesellschaft für Arbeitsmedizin in Düsseldorf. Gentner, StuttgartGoogle Scholar
  4. 4.
    Alderson MR, Rattan NS (1980) Mortality of workers on an isopropyl alcohol plant and two MEK dewaxing plants. Br J Ind Med 37:85–89PubMedGoogle Scholar
  5. 5.
    Bertazzi PA, Zocchetti C, Riboldi L, Pesatori A, Radice L, Latocca R (1986) Cancer mortality of an Italian cohort of workers in man-made glas-fiber production. Scand J Work Environ Health 12 (Suppl 1): 65–71PubMedGoogle Scholar
  6. 6.
    Blot WJ, Morris LE, Stroube R, Tagnon I, Fraumeni JF jr (1980) Lung and laryngeal cancers in relation to shipyard employment in Coastal Virginia. JNCI 65:571–575PubMedGoogle Scholar
  7. 7.
    Blot WJ, Stone BJ, Fraumeni JF jr, Morris LE (1979) Cancer mortality in U.S. counties with shipyard industries during world war II. Environ Res 18: 281–290PubMedCrossRefGoogle Scholar
  8. 8.
    Blümlein H (1957) Kehlkopfkrebs und berufliche Inhalationsnoxen. Münch Med Wochenschr 99:1333–1335Google Scholar
  9. 9.
    Buchanan WD (1965) Asbestosis and primary intrathoracic neoplasm. Ann NY Acad Sci 132:508–518CrossRefGoogle Scholar
  10. 10.
    Burch JD, Howe GR, Miller AB, Semenciw R (1981) Tobacco, alcohol, asbestos, and nickel in the etiology of cancer of the larynx: A case-control study. JNCI 67:1219–1224PubMedGoogle Scholar
  11. 11.
    Butz A (1990) Beruflich verursachte Erkrankungen in den Jahren 1987–1988. Die BG 11:782–784Google Scholar
  12. 12.
    Chan CK, Gee JBL (1988) Asbestos exposure and laryngeal cancer: an analysis of the epidemiologic evidence. J Occup Med 30:23–27PubMedGoogle Scholar
  13. 13.
    Chiazze L jr, Ference LD, Wolf PH (1980) Mortality among automobile assembly workers. I. Spray painters. J Occup Med 22:520–526Google Scholar
  14. 14.
    Claude J, Frentzel-Beyme R (1984) A mortality study of workers employed in a German rock wool factory. Scand J Work Environ Health 10:151–157PubMedCrossRefGoogle Scholar
  15. 15.
    Coggon D, Pannett B, Osmond C, Acheson EDA (1986) A survey of cancer and occupation in young and middle aged men. I. Cancers of the respiratory tract. Br J Cancer 43:332–338Google Scholar
  16. 16.
    Dalaganer NA, Mason TJ, Fraumeni JF jr, Hoover R, Payne WW (1980) Cancer mortality among workers exposed to zinc Chromate paints. J Occup Med 22:25–29CrossRefGoogle Scholar
  17. 17.
    Dauphin D, Huez D, Berthe AM, Lemiere A, Leblanc J-F, Arbeille-Brassard B (1987) Pathologie laryngee et exposition professionelle aux fibres de verre. Existe-t-il un risque cancerigene? Rev Laryngol 108 (1): 67–70Google Scholar
  18. 18.
    Decoufle P (1979) Cancer risk associated with employment in the leather and leather products industry. Arch Environ Health 34:33–37PubMedGoogle Scholar
  19. 19.
    Druckrey H, Gimmy J, Landschütz C (1973) Carcinogenicity of diisopropyl sulfate and non-carcinogenicity of monomethyl sulfate in BD-rats. Z Krebs- forsch 79:135–143Google Scholar
  20. 20.
    Druckrey H, Kruse H, Preusmann R, Ivankuvic S, Landschütz C (1970) Carcinogenic alkylating agents. III. Alkyl halides, alkyl sulfates, alkyl sulfonates and ring-stressed heterocycles. Z Krebsforsch 74:241–273PubMedCrossRefGoogle Scholar
  21. 21.
    Easton DF, Peto J, Doll R (1988) Cancers of the respiratory tract in mustard gas workers. Br J Ind Med 45:652–659PubMedGoogle Scholar
  22. 22.
    Eckardt RE (1974) Annals of industry - Noncasualities of the workplace. J Occup Med 15:472–477Google Scholar
  23. 23.
    Edelman DA (1989) Laryngeal cancer and occupational exposure to asbestos (Review article). Int Arch Occup Environ Health 61:223–227PubMedCrossRefGoogle Scholar
  24. 24.
    Elwood JM, Pearson JCG, Skippen DH, Jackson SM (1984) Alcohol, smoking, social and occupational factors in the aetiology of cancer of the oral cavity, pharynx and cancer of the larynx. Int J Cancer 34:603–612PubMedCrossRefGoogle Scholar
  25. 25.
    Englund A (1980) Cancer incidence among painters and some allied trades. J Toxicol Environ Health 6:1267–1273PubMedCrossRefGoogle Scholar
  26. 26.
    Enterline PE, Marsh GM, Esmen NA (1983) Respiratory disease among workers exposed to man-made mineral fibres. Am Rev Respir Dis 128:1–7PubMedGoogle Scholar
  27. 27.
    Finkelstein MM (1989) Mortality rates among employees potentially exposed to chrysotile asbestos at two automobile parts factories. CMAJ 141:125–130PubMedGoogle Scholar
  28. 28.
    Flanders WD, Rothman KJ (1982) Occupational risk for laryngeal cancer. Am J Public Health 72:369–372PubMedCrossRefGoogle Scholar
  29. 29.
    Forastiere F, Valesini S, Salimei E, Magliola ME, Perucci CA (1987) Respiratory cancer among soap production workers. Scand J Work Environ Health 13:258–260PubMedGoogle Scholar
  30. 30.
    Gerber MA (1970) Asbestosis and neoplastic disorders of the haematopoetic system. Am J Clin Pathol 53:204–208PubMedGoogle Scholar
  31. 31.
    Gerosa A, Turrini O, Bottasso F (1986) Laryngeal cancer in a factory molding thermoplastic resins. Med Lavoro 77:172–176PubMedGoogle Scholar
  32. 32.
    Guenel P, Engholm G, Lynge E (1990) Larnygeal cancer in Denmark: a nationwide longitudinal study based on register linkage data. B J Ind Med 47:473–479Google Scholar
  33. 33.
    Guralnick L (1963) Mortality by occupation and cause of death among men 20–64 years of age: United States, 1950. Vital Statistics - Special reports, Vol 53, No 3Google Scholar
  34. 34.
    Haguenoer JM, Cordier S, Morel C, Lefebvre JL, Hemon D (1990) Occupational risk factors for upper respiratory tract and upper digestive tract cancers. Br J Ind Med 47:380–383PubMedGoogle Scholar
  35. 35.
    Hammond EC, Selikoff IJ, Seidmann H (1974) Multiple interaction effects of cigarette smoking. Extrapulmonary cancer. In: Bucalossi P, Veronesi U, Cascinelli N (eds) Cancer epidemilogy, environmental factors, Vol 3. American Elsevier, New York, pp 147–150Google Scholar
  36. 36.
    Hernberg S, Westerholm P, Schultz-Larsen K et al. (1983) Nasal and sinonasal cancer. Connection with occupational exposures in Denmark, Finland and Sweden. Scand J Work Environ Health 9:315–326PubMedCrossRefGoogle Scholar
  37. 37.
    Hinds MW, Thomas DB, O’Reilly HP (1979) Asbestos, dental x-rays, tobacco and alcohol in the epidemiology of laryngeal cancer. 44:1114–1120Google Scholar
  38. 38.
    Hodgson JT, Jones RD (1986) Mortality of asbestos workers in England and Wales 1971–81. Br J Ind Med 43:158–164PubMedGoogle Scholar
  39. 39.
    Hunermann T (1928) Kehlkopfkrebs nach Gelbkreuzvergiftung. Z Larvngol Rhinol Otol 17:369Google Scholar
  40. 40.
    Hueper WC (1969) Aromatic amino, azo and nitro compounds. In: Hueper WC (ed) Occupational and environmental cancers of the urinary system. Yale University Press, New Haven, pp 68–117Google Scholar
  41. 41.
    Huuskonen MS (1978) Clinical features, mortality and survival of patients with asbestosis. Scand J Work Environ Health 4:265–274PubMedCrossRefGoogle Scholar
  42. 42.
    IARC Monographs on the evaluation of the carcinogenic risk of chemicals to humans (1974) Vol 4 pp 57–64Google Scholar
  43. 43.
    IARC Monographs on the evaluation of the carcinogenic risk of chemicals to humans (1984) Vol 35, pp 39–81Google Scholar
  44. 44.
    IARC Monographs on the evaluation of the carcinogenic risk of chemicals to humans (1972) Vol 1, pp 69–73Google Scholar
  45. 45.
    Jappinen P, Pukkala E, Tola S (1989) Cancer incidence of workers in a Finish sawmil. Scan J Work Environ Health 15:18–23Google Scholar
  46. 46.
    Kauppinen TP, Partanen TJ, Nurmincn MM, (1986) Respiratory cancers and chemical exposures in the wood industry: A nested case control studv. Br J Ind Med 43:84–90PubMedGoogle Scholar
  47. 47.
    Kagan E, Jacobson RJ, Ycung K, Kaidak DJ (1979) Asbestos-associated neoplasma of B-cell lineage. Am J Med 67:325–330PubMedCrossRefGoogle Scholar
  48. 48.
    Kennaway NM, Kennaway EL (1936) A study of the incidence of cancer of the lung and larynx. J Hyg (Camb) 36:236–267CrossRefGoogle Scholar
  49. 49.
    Klayman MB (1968) Exposure to insecticides. Arch Otolaryngol 88:116–117PubMedGoogle Scholar
  50. 50.
    Kolomaznik L, Zdradzil J, Picha F (1963) Incidence of benign neoplasmas, precancerous and cancerous conditions in the respiratory passages of foundry workers, working in an atmosphere, containing relatively large amounts of 3,4-benzpyrene. Cs Otolaryngol 12:1–11Google Scholar
  51. 51.
    Lakowicz JR, Hylden JL (1978) Asbestos - mediated membrane uptake of benzo(a)pyrene observed by fluorescence spectroscopy. Nature 275:446–448PubMedCrossRefGoogle Scholar
  52. 52.
    Laskin S, Kuschner M, Drew RT, Capiello VP, Nelson N (1971) Tumors of the respiratory tract induced by inhalation of bis(chloromethyl)ethers. Arch Environ Health 23:135–136PubMedGoogle Scholar
  53. 53.
    Lloyd JW, Decoufle P, Salvin LG (1977) Unusual mortality experience of printing pressmen. J Occup Med 19:543–550PubMedGoogle Scholar
  54. 54.
    Lynch J, Hanis NM, Bird MG, Murray KJ, Walsh JP (1979) An association of upper respiratory cancer with exposure to diethyl sulfate. J Occup Med 21:333–341PubMedGoogle Scholar
  55. 55.
    Magnus K, Andersen A, Hogetveit AC (1982) Cancer of respiratory organs among workers at a nickel refinery in Norway. Int J Cancer 30:681–685PubMedCrossRefGoogle Scholar
  56. 56.
    Maier H, Dietz H, Heller W-D, Jünemann K-H (1989) The role of tabacco, ethanol consumption, and occupation as risk factors for laryngeal carcinoma. Proc. of the XIV. World Congress of Otorhinolaryngology, Head and Neck Surgery, MadridGoogle Scholar
  57. 57.
    Manning KP, Skegg DCG, Stell PM, Doll R (1981) Cancer of the larynx and other occupational hazards of mustard gas workers. Clin Otolaryngol 6:165–170PubMedCrossRefGoogle Scholar
  58. 58.
    McDonald JC, Lidel FDK, Gibbs GW, Eyssen GE, McDonald AD (1980) Dust exposure and mortality in chrysotile mining, 1910–75. Br J Ind Med 37:11–24PubMedGoogle Scholar
  59. 59.
    Morgan RW, Shettigara PT (1976) Occupational asbestos exposure, smoking and laryngeal carcinoma. Ann NY Acad Sci 271:308–310PubMedCrossRefGoogle Scholar
  60. 60.
    Morris-Brown L, Mason TJ, Williams Pickle L et al. (1988) Occupational risk factors for larnygeal cancer on the Texas Gulf Coast. Cancer Res 48:1960–1964Google Scholar
  61. 61.
    Morrison HI, Semenciw RM, Mao Y, Wigle DT (1988) Cancer mortality among a group of fluorspar miners exposed to radon progeny. Am J Epidemiol 128:1275Google Scholar
  62. 62.
    Moss E, Lee WR (1974) Occurrence of oral and pharyngeal cancers in textile workers. Br J Ind Med 31:224–232PubMedGoogle Scholar
  63. 63.
    Moulin J J, Mur JM, Wild P, Demonchy A, Eloy E, Jeannot A (1988) Etude epidemiologique de mortalite parmi les salaries d’une usine de distillation des goudrons de houille. Rev Epidemiol Sante Publique 36:99–107PubMedGoogle Scholar
  64. 64.
    Moulin JJ, Mur JM, Wild P, Perreaux JP, Pham QT (1986) Oral cavity and laryngeal cancers among man-made mineral fiber production workers. Scand J Work Environ Health 12:27–31PubMedGoogle Scholar
  65. 65.
    Moulin J J, Wild P, Mur JM et al. (1989) Risk of lung, larynx, pharynx and buccal cavity cancers among carbon electrode manufacturing workers. Scand J Work Environ Health 15:30–37PubMedGoogle Scholar
  66. 66.
    Münch H (1989) Berufskrankheit „Krebs”. Übersicht über die Fälle der Jahre 1978–1987. Sichere Chemiearbeit 41:1–3Google Scholar
  67. 67.
    Newhouse ML (1969) A study of the mortality of workers in an asbestos factory. Br J Ind Med 26:294–301PubMedGoogle Scholar
  68. 68.
    Newhouse ML, Berry G, Wagner JC (1985) Mortality of factory workers in East London 1933–1980. Br J Ind Med 42:4–11PubMedGoogle Scholar
  69. 69.
    Olsen J, Sabroe S (1984) Occupational causes of laryngeal cancer. J Epidemiol Commun Health 38:117–121CrossRefGoogle Scholar
  70. 70.
    Olsen J, Sabroe S, Lajer M (1984) Welding and cancer of the larynx: A case - control study. Eur J Cancer Clin Oncol 20:639–643PubMedCrossRefGoogle Scholar
  71. 71.
    Olsen JG, Jensen OM (1984) Cancer incidence among employees in one mineral wool production plant in Denmark. Scand J Work Environ Health 10:17–24PubMedCrossRefGoogle Scholar
  72. 72.
    Pedersen E, Hogetveit AC, Andersen A (1973) Cancer of respiratory organs among workers at a nickel refinery in Norway. Int J Cancer 12:32–41PubMedCrossRefGoogle Scholar
  73. 73.
    Puntoni R, Goldsmith DF, Valerio F et al. (1988) A cohort study of workers employed in a refractory brick plant. Tumori 74:27–33PubMedGoogle Scholar
  74. 74.
    Reif JS, Pearce NE, Fräser J (1989) Cancer risks among New Zealand meat workers. Scand J Work Environ Health 15:24–29PubMedGoogle Scholar
  75. 75.
    Rinde E, Troll W (1975) Metabolic reduction of benzidine azo dyes to benzidine in the Rhesus monkey. JNCI 55:181–182PubMedGoogle Scholar
  76. 76.
    Ross R, Nichols P, Wright W et al. (1982) Asbestos exposure and lymphomas of the gastrointestinal tract and oral cavity. Lancet II: 1118–1120CrossRefGoogle Scholar
  77. 77.
    Rothman K, Keller AZ (1972) The effect of joint exposure to alcohol and tobacco on risk of cancer of the mouth and pharynx. J Chron Dis 25:711–716PubMedCrossRefGoogle Scholar
  78. 78.
    Rüttner JR, Makek M (1985) Mucinöse Adenokarzinome der Nasen- und Nasennebenhöhlen, eine Berufskrankheit? Schweiz Med Wochenschr 115:1838–1842PubMedGoogle Scholar
  79. 79.
    Saracci R (1977) Asbestos and lung cancer: An analysis of the epidemiologic evidence on the asbestos - smoking interaction. Int J Cancer 20:323–331PubMedCrossRefGoogle Scholar
  80. 80.
    Saracci R, Simonato L, Acheson ED et al. (1984) Mortality and incidence of cancer of workers in the man-made vitreous fibres producing industry: An international investigation at 13 European plants. Br J Ind Med 41:425–436PubMedGoogle Scholar
  81. 81.
    SAS User’s Guide: Statistics. SAS Institute Inc. 1985Google Scholar
  82. 82.
    Schlogel F, Bannasch P (1970) Toxicity and carcinogenic properties of inhaled dimethyl sulfate. Naunyn Schmiedebergs Arch Pharmacol 266:441–444Google Scholar
  83. 83.
    Schütz A (1988) Die Ermittlung von krebserzeugenden Gefahrstoffen am Arbeitsplatz. In: Süddeutsche Eisen und Stahl-Berufsgenossenschaft Mainz (Hrsg) Kolloquium - Krebserkrankungen und berufliche Tätigkeit. Verlag H. Schmidt, Mainz, S 11–18Google Scholar
  84. 84.
    Schwartz E (1988) A proportionale mortality ratio analysis of pulp and paper mill workers in New Hampshire. Br J Ind Med 45:234–238PubMedGoogle Scholar
  85. 85.
    Schwartz E (1987) Proportionale mortality ratio analysis of auto mechanics and gasoline service station workers in New Hampshire. Am J Ind Med 12:91–99PubMedCrossRefGoogle Scholar
  86. 86.
    Selikoff IT, Hammond EC, Seidman H (1979) Mortality experience in insulation workers in the United States and Canada 1943–1976. Ann NY Acad Sci 330:91–116PubMedCrossRefGoogle Scholar
  87. 87.
    Smith AH, Handley MA, Wood R (1990) Epidemiological evidence indicates asbestos causes laryngeal cancer. J Occup Med 32:499–507PubMedCrossRefGoogle Scholar
  88. 88.
    Soskolne CL, Zeighami EA, Hanis NM et al. (1984) Larnygeal cancer and occupational exposure to sulfuric acid. Am J Epidemiol 120:358–369PubMedGoogle Scholar
  89. 89.
    Stanton MF, Layard M, Tegeris A, Miller E, May M, Kent E (1977) Carcinogenity of fibrous glass: Pleural response in the rat in relation to fiber dimension. JNCI 58:587–603PubMedGoogle Scholar
  90. 90.
    Steenland K, Schnorr T, Beaumont J, Halperin W, Bloom T (1988) Incidence of larnygeal cancer and exposure to acid mist. Br J Ind Med 45:766–776PubMedGoogle Scholar
  91. 91.
    Stell PM, McGill T (1973) Asbestos and larnygeal carcinoma. Lancet 1:416–417CrossRefGoogle Scholar
  92. 92.
    Stell PM, McGill T (1975) Exposure to asbestos and larnygeal carcinoma. J LaryngolOtol 89:513–517Google Scholar
  93. 93.
    Tabershaw IR, Gaffey WR (1974) Mortality study of workers in the manufacture of vinyle chloride and its polymers. J Occup Med 16:509–518PubMedCrossRefGoogle Scholar
  94. 94.
    U.S. Department of Health, Education and Welfare, U.S. Public Health Service (1967) Occupational characteristics of disabled workers, by disabling condition - disability insurance benefit awards made in 1959–62 to men under age 65. P.H.S Pub. No. 1531, U.S. Govt. Printing Office, Washington DCGoogle Scholar
  95. 95.
    Viadana E, Bross DJ, Houten L (1976) Cancer experience of men exposed to inhalation of chemicals or to combustion products. J Occup Med 18:787–792PubMedCrossRefGoogle Scholar
  96. 96.
    Versluys JJ (1979) Cancer and occupation in the Netherlands. Br J Cancer 37:161–185Google Scholar
  97. 97.
    Wada S, Nishimoto Y, Miyanishi M, Kambe S (1968) Mustard gas as a cause of respiratory neoplasia in man. Lancet 1:1161–1163PubMedCrossRefGoogle Scholar
  98. 98.
    Wagner JC, Berry GB, Hill RJ, Munday DE, Skidmore JW (1984) Effects of inhalation and intrapleural inoculation in rats. In: Guthe T (ed) Biological effects of man made mineral fibres: Proceedings of a WHO/IARC Conference in Association with JEMRB and TIMA, Copenhagen 1982, Vol II. WHO Copenhagen, pp 209–233Google Scholar
  99. 99.
    Weiss W (1982) Epidemic curve of respiratory cancer due to chloromethyl ethers. JNCI 69:1265–1270PubMedGoogle Scholar
  100. 100.
    Weil CS, Smyth HF jr, Nale TW (1952) Quest for a suspected industrial carcinogen. Arch Ind Hyg Occup Med 5:535–547Google Scholar
  101. 101.
    Whitaker CJ, Moss E, Lee WR, Cunliffe S (1979) Oral and pharyngeal cancer in the North-West and West Yorkshire regions of England and occupation. Br J Ind Med 36:292–298PubMedGoogle Scholar
  102. 102.
    WHO-IARC, Biennial Report 1986–1987, International Agency for Research on Cancer (1987) Lyon, France, p42Google Scholar
  103. 103.
    Woitowitz H-J (1988) Die Problematik der konkurrierenden Kausalfaktoren. In: Süddeutsche Eisen- und Stahl-Berufsgenossenschaft Mainz (Hrsg) Kolloquium - Krebserkrankungen und berufliche Tätigkeit. Verlag H. Schmidt, Mainz, S 37–61Google Scholar
  104. 104.
    Wolf J, Härtung M, Schröder HG, Schaller KH, Woester W (1990) Konzentration ausgewählter Gefahrstoffe in Materialproben aus der Holzwirtschaft - Schwermetalle, chlorierte Phenole, Lindan. Staub-Reinhaltung der Luft 90:23–28Google Scholar
  105. 105.
    Wolf O (1978) Larynxkarzinome bei Naphtalinreinigern. Z Ges Hyg 24:737–739Google Scholar
  106. 106.
    Wynder EL, Bross IJ, Feldman RM (1957) A study in etiological factors in cancer of the mounth. Cancer 10:1300–1323PubMedCrossRefGoogle Scholar
  107. 107.
    Wynder EL, Covey LS, Mabuchi K, Mushinski M (1976) Environmental factors in cancer of the larynx. A second look. Cancer 38:1591–1601PubMedCrossRefGoogle Scholar
  108. 108.
    Zagraniski RT, Kelsey JL, Walter SD (1986) Occupational risk factors for laryngeal carcinoma: Connecticut, 1975–1980. Am J Epidemiol 124:67–76PubMedGoogle Scholar
  109. 109.
    Zatonski W (1990) Persönliche MitteilungGoogle Scholar
  110. 110.
    Zemla B, Wojcieszek Z (1984) The epidemiological risk factors of the larynx cancer among the native and migrant male population. Neoplasma 31:465–474PubMedGoogle Scholar

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© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • H. Maier
  • A. Dietz
  • U. Gewelke
  • W.-D. Heller

There are no affiliations available

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